Hey guys SpeedMixer Expert here. Full disclosure I am affiliated with the SpeedMixer folks.
But I’m not here just to “plug” the machine. I am and have been legitimately involved in Cannabis R&D in Colorado on both the CBD and MIP side of things.
In short, I bought a SpeedMixer to accomplish my formulations months before getting involved with the company.
So far we have figured out 7 processes the SpeedMixer can do for Cannabis. Heatless Terpene/Distillate introduction, Whipping, Purging solvents, Infusing, Emulsifying (nano/micro), Extracting, and Grinding/Milling.
Process times can be as short as 30 seconds for say infusing powders sugar, salt etc. For the other processes it can take as long as just a few minutes.
The SpeedMixer can come in a number of size ranging from 100g capacity up to 10kg capacity. But when your process times are just a few minutes you often can get away with a smaller machine because of the fast throughput. The most popular size in the industry at the moment is a 500g capacity version called the DAC600. With many opting in for a vacuum version than can go down to 3 torr.
We have achieved 0ppm RSA in less than 5 minutes straight out of an ETS on tests performed in Colorado. This was for a shatter product.
There is no clean up with this machine as there is no blades or cross contamination because everything is contained within the cup perfect for GMP and ISO processes.
I don’t want to drone on in a long post but if you guys have any other questions I’ll try to answer as best as I can.
I don’t have sugar in the near future sights for my lab, not yet at least. But to go from BHO crude to a 0ppm RSA AND make crumble within < 10 minutes of pulling it out of the extractor, seems like one heck of a time savings to me.
The question then becomes, how many batches of crumble do I need to sale in order to pay off this equipment?
Hey BigOil! Indeed the efficiency saves quite a bit a time. So much so that we had one client make their ROI in just 5 weeks essentially from the man hours saved in whipping alone. That is on the DAC600 Vacuum SpeedMixer. (500g Capacity)
Wakawakalj - Below are some research papers using the SpeedMixer DAC (Dual Asymmetric Centrifuge) for nanoparticles, primarily liposomes. These papers vary in nm range depending on final application from 60nm - 200nm with demonstrated higher encapsulation efficiencies than traditional homogenization methods.
Dual asymmetric centrifugation (DAC)—A new
technique for liposome preparation 2008
Ulrich Massing, Sanja Cicko, Vittorio Ziroli
Matrix liposomes: A solid liposomal formulation
for oral administration 2014
Silvia F. Pantze, Johannes Parmentier, Götz Hofhaus and Gert Fricker
Lecithin-based nanostructured gels for skin
delivery: An update on state of art and
recent applications 2014
Yosra S.R. Elnaggar a,Wessam M. El-Refaie b, Magda A. El-Massik,
Ossama Y. Abdallah
Development and optimization of a new
processing approach for manufacturing
topical liposomes-in-hydrogel drug
formulations by Dual Asymmetric
Sveinung Gaarden Ingebrigtsen, Nataša Škalko-Basnet, Ann
As far as solvent removal goes, that data is all internal at the moment however I am currently working on getting data to publish using Cannabis materials specifically.
Conceptually speaking, during the mix cycle a focal point is created that is a continuous “thin film” exposure allowing for all the solvent to reach the surface and escape. With the low boiling points of butane and propane this is often enough to purge it. To get a cleaner/deeper solvent removal, vacuum can be utilized to drop the temperature even lower and assist in any stubborn gas bubbles. This is all still happening in just a few minutes.
In the case of ethanol and IPA, at 3 torr/mmHG you would be boiling off at sub 20°C (~Room temp) possibly even under 10°C depending on the azeotrope.
In respect to this application the SpeedMixer is functioning as a thin-film rotovap without a heat bath. What we don’t know quite yet is the recovery efficiency. Say if you wanted to run the vacuum line with a condenser column to recollect ethanol or IPA.
I happened to be lucky enough to have one of these bad boys in my make shift lab for experiments. We had a rep come out for training purposes and let’s just say it’s an amazing piece of equipment. As mentioned the units to do a kg are not 10k they are closer to 30k. So far it has been used a handful of times and the rep couldn’t get it to do what we wanted so we have some fancy lab art at the moment. Hopefully when I’m back up for more R&D I get it to work for us. If I can find a video I will post it.