@Cody@Cryo13 Would this dried sugar be able to be absorbed into the mucus membranes in my nose? I want a very very fast onset high like dabs, I’m thinking drinking droplets of the tincture would induce that “edible high” that I’m really not found of.
Typically how fast is the onset for a well made tincture? And is it similar to an edible high?
Snorting it isn’t going to deliver faster than smoking- smoking remains the fastest delivery method. Sublingual application absorbs faster and hits harder than swallowing as it’ll absorb under your tongue and go right into your bloodstream, bypassing your liver… effects felt within 15-30 minutes. if you eat it, onset time is increased and effect decreases. Snorting allows the substance to absorb in the same way to sublingual- but you’ll only irritate your nose when you could just hold the tincture under tongue. If you did snort it, the onset would not be sped up.
Tinctures are perhaps the oldest known method of herbal extraction and preservation. You can use alcohol- higher the proof the better. Vegetable glycerine and vinegar can also be used. Each medium has its benefits and drawbacks. Be sure to decarb your material first, and I’d reccomend doing a cold water rinse for a few days to draw out pigments/saponins - I use a gallon of solvent and a pound of herb for my recipe. You could just divide that down to workable levels if you’re doing a run smaller than that. Lots of methods use heat to speed up the process, but the best ones I’ve made have been at room temp for a very long time. Most people fail at the cold method bc they don’t leave it nearly long enough. Alcohol picks up the cannabinoids the fastest, glycerin tasts great though. Thats what I use to make my gummie bears.
an ounce of flower to 1cup grain alcohol or veg. Glycerin would be my recipe but with smaller amounts.
Might want to look up green dragon if you’re not familiar- but again, I’m an advocate for the cold soak method.
The solubility of THC-Cyclodextrin complex is insufficient for the formulation of most products. In one study, they developed a water soluble complex by the addition of 25 parts RM-Betacyclodextrine to one part THC - or 400 parts of the popular 2-HP-Betacyclodextrin. I myself was able to make a beverage by truly dissolving dry RMB-CD - THC complex. I got about 5mg dissolved in a 12 oz bottle and couldn’t get it any farther than that.
According to Sigma-Aldritch, a 40% RMB-CD solution in water can dissolve 2mg/ml of THC. So you could make a beverage hitting those high medical numbers, I suppose – if you are down to drink half cyclodextrine which does not taste very good. Even if you make a syrup, complex will start dropping out if you try and dilute it. I’ve had much better luck with the nanoemulsion approach.
I dont own one of those cat scientific Hamaginizer yet. How many gallons of honey do you reckon the biggest cat could plow through and how long would that take to accomplish?
Have you prepared the inclusion complex by yourself? What method did you used back then?
“A THC-9 concentration of about 14 mg/mL was reached by using 24% (~0.2 M) Me-β-CD solution, which amounts to an increase in solubility of four orders of magnitude”
I started to dive deeper into the topic of cyclodextrins. Co-evaporation seems to be the best choice to get THC into the cyclodextrin molecules. A lower pH also increases the complexes solubility.
So far I tested beta-CD and gamma-CD, unfortunately without great success.
A minimum of THC was dissolvable with beta-CD, but with gamma-CD, it seems that it only “sticks” onto the CD and becomes lumpy.
In a saturated solution, both inclusion complexes seemed to completely fall out of solution within a short time. Did you experienced the same?
Next ones will be hydroxypropyl beta CD and methyl beta CD