Edibles don’t work on everyone, some people (including myself) just can’t get high from them.
This is a known phenomenon often discussed on Reddit, but I have never seen any research of knowledgeable discussion of it.
Is there any research into this? Any way to make them work? Any idea what is causing the THC not to be digested and passed to the liver? Or is it the liver not processing it? Etc.
Hmmmm. I honestly am surprised. Thc metabolizes into 11-hydroxy-thc (which is much stronger) in the liver after going through the stomach. Since you get high for smoking it i would assume you should do so from ingesting it.
Every person and animal is different. If a compound even had any orally bioavailability (probably >90% didn’t) our ballpark expectation was 90% first pass metabolism. The liver is just doing it’s job of removing toxins. Some higher, some less. Assuming you are consuming d-9, as opposed to THC-A or CBD, it just may not work for you.
So I have a lady friend and I trust what she tells me about 80% of the time. She claims she cant get high from edibles either, and that she researched and found about 1/20 people lack the enzymes to metabolize into 11-hydroxy/norcarboxy.
She also claims (wildly) that she gets rocked from certain transdermal patches. Which I dont understand because phytocannabinoids typically have a very low transdermal bioavailability… I can agree that there probably is some localized effect, but she is the only person I’ve ever met who says she gets high from a patch…