Could acid rain cause isomerization of cbd or d9 to d8?
I know @MagisterChemist use to run a testing lab and hes seen d8 in flower in low quantities
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In CBD hemp, it is systematic. Outdoor and indoor.
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My morals and ethics will not be compromised for the sake of avoiding harder conversations or arguments, ever, for any reason. While not everyone finds value in my generally long-winded PC rants, there are those who have come to me in private, offering thanks and appreciation for what I have said and will continue to say. Even you now using ammended descriptive language shows that you, too, have benefited and grown from our interactions.
He doesnât have to, nor is he trying to (that I am aware of). Hemp is any plant of the genus: Cannabis with less than 0.3% THC by weight. If you canât wrap your head around that, Iâm not sure Iâm the best one to help you there.
I already have, and if you canât tell by the fact that my posts in this thread are more liked than yours, I donât know what to tell you. Not super into flogging dead horses.
Youâre very welcome. Iâm glad I have provided some value despite your implication of the opposite.
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If itâs about double bond placement, you most certainly can. Just a little steric hinderance at the D9 location by tweaking the enzyme.
that would be a case where crispr was the right tool.
After trying it out in E. coli or yeast.
Edit: designing the mod using 3-D modeling is the correct approach. Comparing the structures of various CBD & thc synthases Would be the starting point.
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One of the post docs is my lab is trying to figure out how a weird human disease metabolite trans3MGC-Coa gets turned into the cis version through double bond re-arrangement he already used NMR to determine heat and time catalyze the conversation, Iâm going to ask him if he wants help to find a possible enzymatic candidate.
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6 levels above my pay grade, so please, carry on!
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Such a nice fellow you are. Just because the legislators donât understand the science, doesnât change the facts. Using bioengineering tools to modify the genome leads to a genetically modified organism. Anything else is marketing malarkey.
Is gmo bad? Never said that.
Calling even a crisper based deletion anything other than GMO is solely about the American publicâs inability to science.
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Something that is concerning that no one has brought up is that there is a reason this is only really done by massive agribusiness, and thats the possibility of genetic escape. The moment you deliberately change a genetic sequence with the intention of reproducing and distributing seeds, you endanger the entire landscape of cannabis growers across the world. It only takes one male to pollen and now your precious genetics are infecting traditional cultivars en-masse. Not to mention the downstream ripple effects of genetic manipulation and the unexpected mutations that can result. Not impossible, but tread carefully
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As there is no advantage for the plant carrying the novel profile, âescape and take overâ is alarmist
Stipulating Only Triploids when releasing gmo cannabis might be an appropriate Regulatory response.
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Thatâs one possibility.
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Consumption of GMO products is not what scares me. The science has superceded the âickâ factor and determined it safe (barring the results from 50 year longitudinal studies on the effects of consumption).
Could not agree more with everything you said!
While yes, this is very alarmist, can one be blamed for feeling that when when critically examining the effects humans and their actions have had on the natural world. Seems we have a long history of destroying ecosystems and species with our âbeneificalâ decision-making (usually considered good practice for the time).
Iâd rather be alarmist and tread carefully when the consequences can be potentially catastrophic. (Not that I necessarily anticipate free-moving GMO cannabis pollen to be the downfall of the species)
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Create a dread disease, spread it around, and then sell the cure or resistant genetics. Someone is probably working on that right now.
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No. It doesnât pay attention to science. Totally different concept.
Is CO2 a hydrocarbon? Or even âhydrocarbon basedâ? Oregon defined it as such in their law. That doesnât make it soâŚ
Hemp and Marijuana are both cannabis. Using crispr to modify a critters genome leads to a genetically modified organism. Thatâs the science.
Defining otherwise by law doesnât change the biology. It is merely for the manipulation of public opinion
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Well i agree in general but not in this scenario. There is no evidence that smoking thcp flower day in and day out (or thcp dabs for that matter) is safe and healthy. Iâd be less concerned about the side effects of gmo and more about the intended effects!
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Yeah, but itâs ok. They used crispr so itâs not gmoâŚ
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And the HU-210 version sounds terrifyingâŚ
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Youâre absolutely right, especially concerning the concentrated extract of said plant. I can imagine we arenât too far off from actual (medical definition of) overdose on cannibinoids becoming a real possibility.
Great! Now the one drug that wouldnât kill me and fights cancer (among other things) can kill me now! Who needs a panacea anyway?!
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Hu-210 has already been used during the Spice/K2 craze a few years back.
Potent CB1 agonists lead to overdoses which can lead to hypothermia, seizures and even death. They also show strong withdrawal symptoms not seen with partial agonist like d9thc
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CRISPR is GMO
GMO is also taking a landrace from Pakistan & breeding it with a Mexican oxacan landrace.
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The argument was always âweed canât be bad because people have been smoking it for a million years and no oneâs died yetâ â and that was a good argument I fully agree with. But now that weâre getting into cannabinoids that have no history of consumption by man, that wonât fly. Say what you will about big pharma at least they are called upon to provide some level of proof of safety before releasing something (though sketchy things still make it through of course).
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