I read this and was like someone already told me this 
Also saying terps give an entourage effect is like saying a few beers before you blaze is an entourage effect. 
3 Likes
Implying that terpenes cannot produce or contribute to psychoactive effects is pure ignorance.
Itâs not an entourage effect bro. The terpenes are not modulating the cb receptors. They are independent of each other.
1 Like
Does hop content modulate the effects of alcohol?
1 Like
That we know of, studies are limited.
Iâd gladly argue that they might act as modulators based on the notion that most terpenes CAN bind with both CB1 & CB2.
You might potentially be right that they act independently, you might also be wrong.
The entourage effect has been witnessed, it wasnât associated with terpenes⌠but it is proof that it is without a doubt a real phenomenon, the forefront of science is unsure of how to use it advantageously.
More research is needed.
Well som a bitch. Never really thought of it like that⌠They are cousins after all
3 Likes
Thank you for sharing this, good read.
Thank you @qma
1 Like
Primary lit: SELECTED CANNABIS TERPENES SYNERGIZE WITH THC TO PRODUCE INCREASED CB1 RECEPTOR ACTIVATION - ScienceDirect
2 Likes
Wow!
That study suggests full spectrum extracts are less effective.
As the most effective terpenes are not necessarily the most abundant ones in the cannabis plant, reaching âwhole plantâ or âfull spectrumâ composition is not necessarily an advantage.
This indicates the future of cannabis medications could potentially be specific blends.
I imagine it could used to produce a SPECIFIC recreational high as well, targeting desired effect.
I also wonder if certain terpenes âpairâ with certain cannabinoids⌠the study only covered THC.
Maybe a specific terpene blend with CBD could allow us to fully utilize itâs potential as super effective NSAID!
Consequently, a growing number of studies and caregiving instructions dealing with medical cannabis use terms such as âfull spectrumâ, and âwhole plantâ (e.g., [7], [8], [9], suggesting that combinations of cannabis plant components, more specifically, compositions of selected chemovars, provide better treatment results compared to results of isolated cannabinoids.
1 Like
134a is freon. Is a gas at room temp. Rapidly evaporates at room temp atmospheric pressures
1 Like
Just because something evaporates at STP, doesnât mean it canât exist in a mixture at room temperature.
the vapor pressure of a compound is determined by its molar ratio in a mixture and the vapor pressure of the pure compound.
Thatâs why you can have residual LPG or refrigerant in an extract if its not appropriately purged.
2 Likes
Thanks for this info. Something to look into and kearn about for sure. Ive only had experience with 134a in the HVAC arena, so this is a different and relativity novel concept for me.
1 Like
Check this post out:
Talks about the elevation of boiling point temperature for butane as the concentration of THCa increases.
5 Likes
Dont some terpenes/terpenoid like benzene and shit get you kind of high just by smelling them?
Is ether also a kind of terpene?
Donât they just change their structure by heating, turning them into al kinds of stuff that give a mild buzz when inhaled and snift at?
I was talking to a friend about trimming and cutting, and some people, including myself experiencing a kind of mild high-ish at one point in their life.
Wich should be technically imposible, at least not from the cannabinoids.
It got me thinking maybe terpenes give a sort of high on their own when smelling, just like ether and benzene and probably others do.
Its either that or its a placebo, but it might somewhat explain what is going on.
2 Likes
There is a plant that produces a high comparable to opium and itâs completely legal, it is even referred to as Opium Lettuce
Some evidence of toxicity⌠but they also state in this article it can be extracted and turned into a powderâŚ
Sesquiterpenes/Terpenes are producing the primary effects associated with the high.
I can link sources if needed.
This ancient literature even argues that âopiumâ from lettuce is superior to that from the poppy.
1 Like
If that study is right then everyone saying âbotanical derived terpenes donât do itâ is wrong. Because they tested pure individual terpene isolates and got an effect.
Remember everyone, if someone you trust tells you âoh yeah these CDTs I made are super fireâ⌠youâre going to think itâs super fire. The same LSD can cause a good trip or a bad trip. Itâs your MIND and EXPECTATIONS that change things.
I think 99% of the anecdotal descriptions of entourage effects are just that. Terpenes do modulate effects, somewhat, I believe, but your own mind will modulate it 10 times more.
Someone commented âwell if terpenes arenât important why not just smoke distillateâ. Well I did, for months, in unflavored vape carts (easier on the lungs than ones with terps added). It was great. Donât knock it till you actually tried it.
3 Likes
I agree that the study is flawed, I only provided it because I remembered its existence. Scaling reviews has been a nightmare, as anecdotal evidence is all over the place
I no longer ask anyone to describe the effects of strains to me before I buy them. I just ask for something that smells nice. I donât think people who claim their strain gives a specific headspace are telling you anything that exists outside of their own mind⌠They smoked it once, they felt a certain way, theyâre convinced youâll feel the same way, you listen to them, you believe it, and your belief makes it so. Simple as that.
This is a totally separate question from âdo terpenes modulate CB1â. They do or they donât, but iâm pretty sure thatâs not what is actually responsible for âstrain specific effectsâ.
2 Likes