(Like, the grain of salt you need could salt roads)
So!
The #1 grievance I hear most commonly is “it makes me anxious”. My hypothesis regarding this has to do with one of two factors. Either it’s too high in THC, unfamiliar to the consumer, or a terpene profile so heavily layered thanks to the great “hybridization”.
If you give a person a dosage of something more so than one is accustomed to, then the likelihood of their body responding negatively could theoretically go up.
I have noticed with the older, more mild strains, I haven’t observed negative reactions, even when consuming beyond their normal means, or consuming in ways that isn’t normative to them.
My theory is as follows, THC by itself, tends to let the mind race, too layered a terpene and other active compound profile, and your body gets overwhelmed.
(I know this is entirely subjective, but this is the theorem I tend to go by after observing hundreds of consumers of various age ranges personally.)
‘studies have shown that a gavage of β-caryophyllene activated CB2 [5] and topical application of it up-regulated TRPM1, TRPM6, TRPV4, and TRPV6 of the TRP channels [2]. These studies indicate that β-caryophyllene activates at least three types of receptors: olfactory receptors, TRPs, and CB2.’
Huh … I keep finding contrary evidence. As well as personal experimentation. Pretty sure alot of links in this thread are cross reffed in the below study as well.
right on, frankly i love it when this happens, thanks for posting
fave part so far: ‘All terpenes were purchased from True Terpenes’
’ Importantly, this study cannot rule out the existence of an entourage effect for terpenoids. However, in combination with Santiago et al. (2019), there is likely now sufficient data to rule out direct interactions with either cannabinoid receptor as being the mechanism by which an entourage effect is mediated, so attention must move to other types of effect. Within the endocannabinoid system, this would mean investigating the effect of terpenoids on metabolism or synthesis of the endocannabinoids’
seems that this does have a lot of evidence to disprove ‘direct’ interactions with the cannabinoid system/receptors, and β-caryophyllene’s binding to CB2 appears to be a weak one. doesn’t discount that they may modulate in other ways, and i think important to keep in mind, only studied 5 terpenes.
very fun to think about where these studies overlap and where they disprove each other’s findings
It could have something to do with like isoprenylation with protiens or some other kind of pharmacological interaction. Like I’ve said above, I really think we should be looking more at polyphenols as far as “modulating” the cb receptors…
A point the guest makes on the Hamilton podcast also talks about how much terpenes(very small), the route of ingestion(typically inhaled), and degradation(smoke and vaporization) by the time the body can metabolise them(are they still terpenes?). It’s important information we all forget to think about.
couldn’t agree more on your last point. a lot of these studies seem to apply more to aromatherapy than cannabis consumption by simple concentration or lack of
Keep in mind these articles and research papers are literally brand new, some of these just a year or two old. There’s gonna be significant argumentation to present both sides of the coin.
I’d make the argument, regardless of effects on direct CB stimulation, undoubtedly, aromas do cause stimulus, how much and what direct pathways, admittedly, I need to look into more.
New things to look into! This is literally cutting edge stuff, if buffed on it, our formed opinions on it now, are literally the latest of scientific discussion on this.
where we’re goin’ we don’t have no stinkin’ map
Pyrolysis is reasonable to presume that the substances change due to temperature, but it’s the vaporization and inhalation of intact compounds that allows for the effects. Goal regardless of ingestion, is inhalation of these vapors.
@vortal thanks for rebuttals and counter points, wouldn’t be a very intriguing conversation without it.
I’m not the biggest fan of terpenes compared to some, but I still think they play a vital role. They set the tone for the session. It is THE sensory memory/mechanism imo. I feel like this is why we chase the legacy sour/skunk strains alot of us really enjoyed as younger people. Cause honestly the whole skunk/sour thing leave alot of flavor out…
Even if it is placebo effect or sensory memory, why can’t that be enough? What you think about comes about. We manifest our reality, and then you add cannabinoids to assist.
And that’s the point I generally fall back on, regardless of arguments on pathways, never, ever doubt olfactory senses.
And you nailed why I’ve had affinity for “the classics”.
I also feel more mellow profiles leads to a more laid back smoking experience, I feel like new boutique strains (although awesome) overwhelm the olfactory senses more, and could be why they have more “heavy” effects.
Totally a pot shot in the dark, basically blindfolded.
REAL CDT make cannabinoids more bioavailable!!! It’s why we crave terpy “loud” cannabis buds.
Think about this … High THC %'s does not always equate to high potency cannabis effects.
Many of us have had 15-20% THC cannabis that was way stronger than 25-30% THC
It’s because of the TERP CONTENT!!! Fire terps wiiiiiiiiii rrrrrrrrr wiiiiiiiiii errrrrr …
More terps more efficient uptake. Bioavailability goes way up…so you need less… But CDT on its own doesn’t do much…it’s an entourage thing.
They sorta dictate the direction of the buzz too imo. I’m puffin on some blueberry haze rn and its got me feeling happy and kind of laughy.
Long story long…CANNABIS TERPENES are very important…but they need to be paired w/ cannabinoids to achieve this wonderful type buzz.
ENTOURAGE EFFECT of AFFECT
Edit BOGUS replica terps do not achieve the same effects. It’s just like smoking raw distillate that has flavor. Pic coming to show you what that’s like
Many terpenes just have completely different mechanisms outside of cannabinoid receptors. An easy example for times where terpenes in nature have known psychoactivity would be Thujone. It is a monoterpene ketone that is widely researched due to its role in absinthe.
Like many terpenes are now, Thujone was long believed to interact with cannabinoid receptors but instead was found to be a GABA receptor antagonist. Meaning it produces stimulant-like effects opposite to alcohol or benzodiazepines.
People should take the focus off of cannabinoid receptors for a bit and remember there’s a never ending way for chemicals to make you feel “high,” especially when you inhale them. Most of which we still don’t fully understand and especially not when consumed in a complex mixture. We need to map out the entire composition of the resin long before we try to make sense of random anecdotal evidence and glorified marketing materials.
REAL CDT make cannabinoids more bioavailable!!! It’s why we crave terpy “loud” cannabis buds.
Think about this … High THC %'s does not always equate to high potency cannabis effects.
Fire terps wiiiiiiiiii rrrrrrrrr wiiiiiiiiii errrrrr … 
