Israel has some of the most scientifically advanced cannabis research on the planet. This Israeli researcher gave at TED talk about 4 years ago that may tend to dispute your assertion (and since then Israeli scientists have made some more amazing discoveries. you should look them up)-
This is a great video, but he never once mentions terpenes or any other polyphenols. He strictly talks about cannabinoids.
So no one has heard of Dr. Ethan Russoâs work on this from like a decade ago?
iTs JuSt BrO sYeNtS
It is bro science. Pharmacology is real science. Like I said above⌠all science points to terpenes interacting with a totally different set of systems than cannabinoids. You canât put ear plugs in, and say they turned the volume down. They made you experiance the noise differently but they didnât really change it at all, and they actually have nothing to do with the sound at all.
So the entourage effect is real or no?
The thing is when you distill and pulling terps off you will pull off some of those cannabinoids heâs talking about. And I say this is a person who makes his living distilling. If your concern is purely recreational and nothing to do with therapeutics then it doesnât matter.
It is not real. 1:42:30 you can actually listen to an expert touch on the subject, and start your own journey. You can tweet @samuel_b_phd on Twitter and heâll probably respond.
Does anyone remember Dr. Mark Scialdone talking about the entourage effect on Hash Church a couple years ago?
I thought he said something about how the non-polar nature of the terpenes helps open up some type of pathway through the blood-brain barrier that facilitates easier passage of THC.
Does that ring a bell with anyone?
We can all argue until we are blue in the face until we have the actual data.
Until then experience tells me I enjoy terpenoid-associated fractions with my cannabinoid fraction.
10 years ago people would suggest mangos and lemongrass would provide enough myrcene to help thc penetrate the blood brain barrier further than without. It seems pretty obvious to me that terpenes act as a vehicle to help deliver the cannabinoids to different places it couldnât travel as a solid state vs a solution.
Ditto.
Real world experience definitely points toward magnification of effects with both present.
Good bot
Terpenes are the primary constituents of essential oils and are responsible for the aroma characteristics of cannabis. Together with the cannabinoids, terpenes illustrate synergic and/or entourage effect and their interactions have only been speculated in for the last few decades. Hundreds of terpenes are identified that allude to cannabis sensory attributes, contributing largely to the consumerâs experiences and market price . Terpenes Flavors to The People!
Research changes every day and anyone that claims to have all the answers is a quack doctor. The research experiment done about a year and change ago that âdisprovedâ the entourage effect was fully debunked. University of Arizona claims just the opposite
Study shows Cannabis terpenes provide pain relief, contribute to 'entourage effect' -- ScienceDaily.
This one too
Until we have receptor binding studies AND protein pathway activation studies we wonât have the full picture.
beta-Caryophyllene preferentially binds the CB2 receptor and activates it. (It does not do this to the CB1 receptor.). This is well documented in the scientific literature, e.g. binding affinity, reversibility, and where on the CB2 receptor this terpene binds.
This leads one to believe that the relative amount of âhead highâ and âbody high/effectsâ is partly a function of the (relative) amounts of this terpene in different cannabis products.
If interested, start your literature search here:
Iâll repost my last âhuhâ paper regarding this, posted in another thread.
âTerpsâ loosely termed here including other aromatics, are a major factor, and they do absolutely have effects on the CB receptors.
If they didnât effect mood, Iâd figure we wouldnât use them in aroma therapy.
Sit with some trippy kids and have them blast rose water in your face, bet youâll find it quite soothing and relaxing.
Thereâs certainly something there.
i think this is the most fair statement on where weâre at in our understanding of this theory/phenomenon/thing.
a few terpenes are confirmed to actually bind to cannabinoid receptors; hard to say they wouldnât have something to do with modulation of experience.
a lot of terpenes donât bind to cannabinoid receptors; however itâs likely they play a role in influencing the âsetâ of the user, and then the cannabinoid effect has a different canvas to play on; less of a direct effect but an effect nonetheless.
some terpenes do neither, but appear to increase the absorption of other compounds.
the conception the user has that âthis strain is an indica/sativa or is known to make me feel this/that way bc leafly or the budtender said it wouldâ will influence the perceived experience, because the mind is a powerful thing.
we havenât even begun to understand the role that all those minor cannabinoids at >1%, that we donât even see on most COAs, play when in this ratio vs. in that ratio vs. combined with this or that terpene profile.
then, the way these play out person to person, and things like the fact that long time cannabis consumers tend to notice a difference in the effect cannabis has on them when they first started vs. 10 years later (how many people do you know âdont smoke anymore cuz it makes me too anxiousâ)
i realize iâm not stating anything that hasnât been stated already. i just think that given weâre just cracking a lot of this open, and given the incredibly complexity of testing the effects of so many variables on so many different physiologies, i donât understand how anyone can claim that the theory as we currently conceive it be completely true or untrue. we have some clues but far from anything resembling a true understanding. itâs somewhere in between, and we should adjust the theory to fit the ongoing research. weâre just not there yet and wonât be for awhile, and thatâs why itâs called a âtheoryâ
hard to argue that
