my weakness as well
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its easy to put on a scale but i didnt and then its no fun edibles need to be treated appropriately and not handing cans of shit to kids. who knows how many cans he drank? when i was a kid id drink coca cola like crazy and 2 cans would go down easy on a 10 minute work break. i get super pissed when my wook drinks beer- he does it in a bad way and drinks super fast and he drinks 4- 1 of me? and it kinda makes me drink more than I would but thats because im frustrated dealing with him. id insta fire if on a real job a while ago he recognized but hes stupid= he started sneaking in liquor. he thought im mad at him for drinking MY beer. No just dont be drunk
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Not always the case, had a guy eat a 1k mg chocolate bar all at once cause he can dab 5 grams a day easy i saw him do it for yrs. That chocolate bar had him green and puking like he was tequila drunk. 2 days later he said and i quote â fuck i should have listened i thought i was a soldier on smoking and that edible ruined meâ
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Another question is if the kid has been vaccinated
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I can smoke a lot but edibles do kick my ass depending on the dosage. When I had a month T break, I ate 1 25mg gummy and was trashed for the rest of the night.
Normally I would barely get a buzz off 25mg
This was a question of mind too
I have a firm stance that vaccines are causing underlying conditions that can inevitably get triggered by substance use or other trigger events.
Considering his age too if his parents wanted him jabâd he would have no say
We know itâs the D8 as this to my knowledge hasnât happened with D9 as itâs effects arenât nearly as strong as D8 on lighter doses and D8 is new.
Youâre correct, but there is also underlying conditions that will have made it worse when combined with a sketchy cannabinoid.
Like TxIsBest asked, was he jabâd?
I wonât say cross tolerance isnât a thing, but just because something hits the same receptor doesnât mean it activates it in the same way.
I mean, there are partial and complete agonists you know. Kon and Koff binding constants are a thing.
Also âsmokingâ tolerance includes entourage, you can switch strains and bypass a good bit of smoking tolerance simply through entourage.
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I think more studies the merrier. Just be careful on hypothesis from it. So many uncontrollable variables with people reacting different to the same chemicals.
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Just the multiple neurotypes alone suggest a variety of different experience possibilities. Anyone who has seriously looked at one of those combined cellular metabolic pathway charts understands âŚthose levels of complexity boggle the mind.
What Iâm saying is the whole cross tolerance thing seems based on a fallaciously simple model.
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I still find a MI really hard to swallow off a 150mg dose of lipid based nano emulsification of D8. How much could it have been? 12oz
You need to subpena the medical records. I gurantee there was other perception drugs, alcohol, or elicit drugs involved.
I spoke to a couple friends, and it seems like the best defense would to be a character assassination, or buredon of proof, as this could be fairly hard to produce. Just like it is very hard to sue a restaurant for food poisoning.
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It is common knowledge that thereâs a cross tolerance. itâs also common knowledge that 11 hydroxyl lasts longer and Is 2 to 3 times more potent. I canât imagine itâs a full agonist of the receptor like thcp because we would know that from peoples experiences. Itâs potent but itâs not that potent (I.e. putting people in cannabinoid clinics like in Europe).
I rarely eat edibles but I can eat a lot more than someone with no tolerance. Demonstrably, repeatedly. All these weird outlier stories are cool but go back 20 years before all this Cornball cannabis marketing and go around telling everyone contrary to their absolute experience , they can just switch up between edibles and smoking to keep zero tolerance âŚ
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Also 150 mg is a huge dose for someone with no tolerance .
I didnât smoke for a few years and then started growing my own. The first test bud I tried a tiny puff off of, not even a mature plant , sent me onto the âdeathâ trip. The one where you think youâre dying and dead and then you contemplate life itself and how everyone you know and all their progeny and everything is finite.
If you donât think 150mg , which is like 300 to 450 mg smoked , could give someone a frightening experience, in the words of my beloved aunt K, thatâs ignorant.
seems like a thing for benzos and barbituates with alcohol but Iâm still skeptical itâs a universal thing for d9 and 11-OH-d9.
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Yeah, but they hit up the same receptors.
How are people liking this comment? No offense intended. Cross tolerance absolutely comes from the receptor, not from which particular cannabinoid youâre consuming.
I canât avoid a tryptamine tolerance by simply switching from LSD to Psilocybin, and you wonât find yourself with âzero toleranceâ if you have an edible for the first time in 6 months if youâre a daily dabber.
Absolutely, 11-hydroxy is an order more potent, but I disagree with the assertation that cross tolerance isnât a large factor here.
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I have never in my life had this experience. One time when I first started working at a lab, I drank 500mg and got the Holdol shuffle. But I was just âreally highâ. I am âdiagnosedâ ADHD so maybe my body metabolism is different?
Or maybe you need to borrow someone elseâs liver in order to produce 11-hydroxy efficiently⌠Converting to 11-hydroxy
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Cross tolerance I think isnât something anyone is disbelieving, itâs probably just not the right technical term. We all realize virgin receptors from our first time vs our tolerance changed receptors.
That doesnât change the completely different chemical and body changes. Not everything is just head high either. Clearly with edibles we experience more body changes.
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Everyoneâs body chemistry is different. Your ability to handle high dose edibles comes down to your own personal absorption of those cannabinoids.
I smoke heavily all day and if I even eat a little bit of weed it knocks me on my ass.
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Thatâs cool. But they arenât the same drug.
Inhalation goes to the lungs, bloodstream, then the brain. Edibles go to the stomach, then go to the liver and only a wee tiny bit gets converted to 11-hydroxy, goes to the bloodstream. Then, that hits the brain. It coming from thc still doesnât mean that smoking gives you a tolerance. They still arenât the same drug. Having low liver enzymes can make you have a ridiculous tolerance for edibles, when you never have them. IE: my old employee in az, average smoker. I give him an edible that I normally take (extremely high tolerance) expecting him to take it later on. Fuckin @terpenedaydream takes the fucker right there. Barely feels anything from it. Another friend of mine who is a regular daily smoker and an extractor. Can only handle low, low potency edibles or heâll get trashed. But, he takes dabs and smokes doinks all day.
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