Info on THCV

Whos got it, how do I find it, how does one make it? is there any way to isomerize or otherwise create it from other material? I can’t get it off my mind and it seems to be quickly becoming a big name .

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Equatorial strains (african) have the highest content (8%) highest sensi seeds have found
Seperating is unknown to me for now
But LLE with mixed solvents should get the job done according to organic chemist professor
Not aware of other plants that produce it

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Your looking for genetics from the “last landrace” a Zimbabwe native. the strain hunters found a couple years ago. I can get seeds with this used as the father, the breeder I know renamed it the “lost kingdom”.
I dont think thcv can be isomerized from d9 thc or cbd

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The -varins all have a 3 carbon propyl side chain tail instead of the 5 carbon pentyl tail. Adding length to this tail increases potency(dimethylheptyl has been explored extensively in HU series)so it stands to reason the shorter tail on THCv would be very weak. Literature cites it as a CB1 antagonist meaning it will reduce THC and other cb1 agonists effects. In non-cannabis using populations, it will likely have some effects including appetite suppression(anti-munchies) due to reversing the effects of endocannabinoids at CB1. Human testing of pure THCv is limited, while likely safe even in high doses, stronger irreversible antagonists of CB1 have proven fatal in humans.

It’s starts with a different precursor in the plant and synthetically and would be difficult to make one from the other.

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It cant be isomerized but you can convert it, I’m pretty sure @Deleted showed me a diagram on how to synthesize thc v, I don’t remember how he said to do it though and I think you needed to be able to recarboxolate to do it if I remember correctly which is why he couldnt complete the reaction.

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This is totally off topic: if delta 10a reduces appetite ( which it does) do you think that means it’s a cb1 antagonist? Where did you find this info in thc v? Google?

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Can you site study that says delta 10a reduces appetite?

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Me and several people who have consumed it say it reduces appetite

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The highest THCv strain in the US so far is Black Beauty or Negro Bonita. Its like 6-8% THCv in cannabinoid profile.

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That sounds nice, negro bonita… The lost kingdom my buddy had had a pheno hit 6% THCV, so they are definitly out there, well soon see some in the mid teens

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Well that is rather anti-climatic… I look forward to some legitimate medicinal studies on this materials so we do not have to discredit our own industry by making anecdotal claims.

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do we even have solid data that we’re dealing with delta 10/10a?

last time I looked (six months?) we did not seem to…

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Not that I know of. Would love to see some inkling of hope!

C&EN News has this schematic on synthesizing analogs of cannabinoids using Tsuji-Trost conditions

https://cen.acs.org/pharmaceuticals/pharmaceutical-chemicals/Natural-extracts-synthetics-square-off/96/i46

Tsuji Trost information

https://www.organic-chemistry.org/namedreactions/tsuji-trost-reaction.shtm

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Go read the delta 10a thread, it’s been verified by NMR and several other testing procedures. Were pretty sure we figured out the catalyst too. I’ll be trying to make some next week

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can’t find a “10a thread”.
lots of hits though…
http://future4200.com/search?q=Delta+10a
http://future4200.com/search?q=10a
http://future4200.com/search?q=Delta+10

I’m assuming you mean the Delta 10 THC thread YOU started three weeks ago?

I see you’re convinced.
I don’t see hard data.

care to link it rather than just tell us you’ve seen it?

edit:

which is helpful, but not the primary data.

I’ve seen Steephill call it delta10, which seems like a fairly solid indication that that is what we’re looking at.

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Much of this information is proprietary at the moment, as a lot of time and money has been invested surrounding delta 10. We have NMR results (1H, 13C, NOESY, HMBC, COSY, HSQC) and further analytical work is being done. If you’d like to see spectrograms, be willing to sign NDA and send me a message. I’m hopeful that we can release the info soon enough, just making sure all fronts are covered.

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Theres your answer, I’ve seen the data I just dont have it and cant disclose it. I signed the NDA. Talk to @extractepic

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Works for me guys.

Like I said, last time I took a look at it, folks still seemed to be guessing.

I’ve made it and can quantify it if that’s what it be.

I’d need @QGA or @Photon_noir to walk me through the nmr data anyway, so I’ll let one of the DM about that NDA :shushing_face:

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You are making people sign NDAs to look at your spectroscopic data?

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