correct.
Out of curiosity, what is the point of making d8-THCA - just novelty? Is there truly a market for it - presumably it will vaporize like delta 8 THC so perhaps for eating? The novelty of having a crystalline solid isnāt negligible, but it seems like not a ton of pure delta 9 THCA is flying off of shelves? I have a prep for delta 8 THCA, but I donāt really see the purpose other than likeā¦to say ya can? Am I missing something, is there something particularly viable about this molecule or is this more likeā¦a collective curiosity about a less common but easily conceived cannabinoid?
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For science!
Crystallization as a means of clean up is attractive considering the plethora of potential unknowns in any given conversion.
Many people would rather smoke diamonds than other forms of concentrate. I generally see them retail at higher prices than say shatter.
Naturally, I just wanted to see if I could make either D8 or d9 THCA from cbda and Iāve got loads around so I thought Iād go for it.
Idk if thereās any supporting literature but I saw someone around here say that the expanding co2 from decarb drives thc further into your lungs. Seems legit.
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Yeah purification- that baseline separation takes the isomers out of the equation
Siiiicccckkkkk
That is all
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Iām only interested from curiosity. Is it orally active?
I posted this in another thread, keep forgetting to take a shot of the integration
Some distortion there but good enough to verify a rxn occurred. We both have similar peak proportions on the CBC, D9a and the ? Peak. Looks like my retention might be slightly shifting- ill spend some more time with it
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If you have CBDA around, by all means itās interesting work. But youāll have to purify your CBDA for more reliable experimental design and pure CBDA is probably worth something on its own. Thereās more to the story than price on the shelf, and thatās units sold. Back in like 2016-2018 in OR I would see the same unsold grams of THCA isolate sitting on the shelves listed at like $70/g for months on end. I think once the d8 THCA is synthesized and isolated, youāll have to confront formulating it into something for it to be a product people repeatedly purchase.
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So are d8 diamonds a real thing ?
no.
((((( fucking char limit
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Not yet. Weāre merely checking if its possible. After someone confirms its, thereās still lots of work to be done given we determine its viable. Method development, cost analysis, impurities profiles, etc. Thats all also after we isolate it if it is D8-a
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Exactly !
Still, as written above, it better be proceeded from pure substrate, and will likely produce the unknowns-Aā¦ letās hope they are much easier to get rid of. The crystallization is definitely the most convenient method.
Looking at that chrom, Ive seen D10 come out around that time too, behind D9THCA (but baseline separated on my method, id guess we are doing similar methods). Id speculate D8THCA would come off right behind D9THCA (without good separation) just like with the neutrals.
Do you have a mass on that peak? Does it have three UV maxima like all the other acids? It should if acid have the secondary ~270nm and a smaller ~300nm hump noticeable from the main ~224nm peak. D10 or other neutrals would only have the one main peak.
Also seen CBCA come out in that region, and looking at your inject noise looks like the bottom abs. is much lower, so could possibly be CBCA from your starting product? That would have the same mass/uv abs pattern as D8/9THCA. But CBCA is baseline separated from those for me.
There wasnāt any CBC/CBCa in the starting material as you can see up top, so whatever those 3 peaks are have to be products of the rxn. I will note that because Iām seeing some tailing there, the retention times could be slow, but Iāll do the integration and see what it looks like- I had applied some data processing the other day to āidentifyā the peaks but just havenāt had time to get back to it. I do not have the mass, but weāre detecting everything at 228 I believe. Again I am not using the ammonium formate buffer, so itās possible they arenāt even acidic cannabinoids. Iāll update when I have more info, I plan on having it tested for as many cannabinoids I can.
I see the scale on the abs. is very different on top (large) and bottom (small). I could see somebody easily overlooking the very small CBCA peak in the top if there was one at that abs scale. I do see some smutz on the top that could be those peaks on the bottom possibly if zoomed in.
But if that top sample is CBDA distillate?.. maybe there is no CBCA in thereā¦ but if it is just hemp extract then yes there is CBCA and CBGA. You dont have the plant make CBDA/THCA without it making CBCA at ~2%+ and also CBGA.
Would short path separate CBGs and CBCs from THC/CBD? I am skepticalā¦
It is not a distillate, that would decarb into CBDā¦it is a hemp extract, but there is not significant amounts of anything else in this sample besides CBDa. It has been mostly separated from the rest of the extract.
CBDa does not crystallize as readily as CBD, so the purity is about 80% CBDa with trace amounts (<.5%) of other cannabinoids. We have analytics on the starting material, there was no overlooked CBCa or CBGa or their decarbed counterparts- There is a D8 peak, though, with the usual offenders, and no CBDa anymoreā¦
Sir, if it is a hemp extract, you will have extracted the CBG/CBCa that was also in the hemp and concentrated it. If you did not separate them out, those analytes will be there at significant amounts of 2ish+% (maybe not significant compared to the absolute CBDa amount but they will show up when that Y axis is zoomed in on the topā¦ I can already see them I think). But I really am not trying to argue about that, just throwing out some candidates is all, not my business if it is CBCa or what. Although I could see CBGa getting obliterated by most chemical conversions as it seems the most unstable of the cannonical cannabinoids in my experience.
If you really want to discriminate between acids vs neutrals on UV though, youd just take the 228/300nm ratio from your DAD. The acids will be readily apparent (low 228/300 value) and you could defiantly tell if what you are making is an acid.
Shatter CBDa101520.pdf (102.9 KB)
of course the D8 was formed due to the CBD content
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In that COA how do you have ND thca but detectable d9 when there is a majority of cbda in this sample?
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chromatography- THCa and CBC come off last, we left them out. In fact, if you look at the COA, they list the cannabinoids in order of HPLC elution
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