Yeah it can produce stable emulsions that outperform the fancy nano-emulsions. It can be turned to a powder and used in any medium, even low ph liquids
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What do you mean by “sodium hydroxide buffered”?
We need another ingredient to achieve “buffer”…
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Yeah - otherwise the pH is much higher like 12.5-13. for Sodium Hydroxide. Are we using something else in the solution? Are we saying the other ingredients are providing this buffering ability? Are you using the lecithin as the buffer? I mean… that’s a lot of lecithin…
Do you have the tables in mols per reagent? 
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Citric acid and Potassium Citrate usually
I really don’t know the full relevance of the ph during every step. I’ve made extremely powerful batches with tap water and no attention to ph. Ph readings are difficult to achieve as well once everything is in solution due to the oil content of the mixture. The orientation of the phospholipid chain can cause phospholipids in solution to behave as a web that exposes or entraps water content. There are also multiple compartments forming with varying densities and ratios of solvent/water/oil/api. Each one of these compartments will have different ph capacity. This isnt an entirely homogeneous emulsion until the final step. The lecithin will fraction out and pull different ingredients into the different layers. It breaks the azeotropic bond between the ethanol and the water. Incorporating ph considerations and alterations has always been a future task for me but never a priority due to the high functionality of a non-ph adjusted batch. I have some opinions about ph alterations due to the fact that I toyed around with them for a bit. But I accidentally made some stuff that targeted heart tissue too selectively. It would make your heart race and it also had a strong affinity to potentiate water soluble drugs, whether they were in the stomach or in the bloodstream already. I have some theories of mechanism for how alkaline dissolved phospholipids could flood the bloodstream and blanket free floating drugs and/or create temporary ph alterations at the cell sites around receptor interfaces. This could in theory cause a temporary flood of a substance into cellular compartments that can potentiate them after they’ve already went into the bloodstream. Enzymatic deactivation, receptor competition, receptor shielding, endosomal retention reversal, etc. Who knows what all mechanisms could be at play but don’t say you haven’t been warned. Specifically; high ph buffered PEGylated formulas with low alcohol content have done this for me.
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Yep, that pair would buffer. In the ph 3-6 range.
So not relevant to “alkaline water”.
Are you deliberately trying to mislead?
Or unclear on the concepts?!?
A buffer has an effective pH range of one pH unit on either side of the pKₐ value for the weak acid . If the pH of a buffer goes out of this range, the buffer will no longer be effective at resisting large changes in pH.
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Maybe…
This one is over my head
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I think you should calm down and explain why the ingredients potassium Citrate, citric acid, and sodium hydroxide have to be at 3-6ph? Also, the final ph of the mixture is what I was referring to, not the alkaline water used to dissolve the lecithin. It would probably be easier if you just try the method with no regard for ph at any step, then adjust ph and see what occurs. Also, this is a method that I invented that I’ve claimed is still in development. So I’m not sure how I would even be able to mislead. You can just ask me to clarify statements instead of looking for a way to shoot holes in things. I posted this info to get people curious and so they could make this stuff at their house and have fun with their own alterations. I can only give my observations and perceived mechanisms on most aspects of it because it has been quite exhausting to just finish the project enough to be able to put guides together for it.
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In order to BUFFER.
Outside that range, you are not looking at a “buffer”, at least not one that is buffering based on those ingredients.
This is basic chemistry.
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No. The ph has very little to do with why any of this works as far as I’ve seen. It creates instant acting products at ph ranges from 3.5-9ish ime. The lecithin is used for a variety of reasons. It’s a stacked ethosomal structure. Every component and step is playing a specific role
Well what would a 6ph buffer be called if you added a bit of sodium hydroxide to it and it reached 7 or 8ph?
I’m not the one who claimed
“High ph NaOH buffered…”
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No longer a decent buffer
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I understand what you’re saying but I don’t know a better word. Maybe it’s an unstable buffer? It is also compartmentalized and held at different ratios in the final mixture. The mixture isn’t homogeneous on a small enough scale
And I’d like to understand those roles, and NaOH was not playing the role of ph9 buffer. Neither is the citrate.
Which means you’re either feeding us misinformation deliberately or don’t actually know what’s going on.
Those require different approaches if trying to replicate your work
“Solution”. It’s not a buffer unless it resists your attempts to change the pH.
I suggest making a pH 6.0 citric acid based buffer and titrating to ph9 with NaOH. Just for your own edification.
Maybe start with store bought:
When you misuse words that have very well established meanings, it becomes much harder to communicate.
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Which may well mean your solution IS (well) buffered…
It’s just not the NaOH, nor the citrate.
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Is that “no the lecithin is not the buffer”?
You sure about that?!?
Can you make heads or tails of the paper I posted that might address that possibility in a rational fashion?
(Aka what IS the pKa of “lecithin”?!?)
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Reread my post and you’ll see that I tried to adjust final ph and ph during intermediate steps and accidentally made some things that were too dangerous to continue exploring the effects of ph alterations. Look up targeted ethosomes and you’ll see what I am talking about. There are cellular structures that can preferentially latch onto specific tissues in the body. Moderna targeted the mitochondria with the mRNA Vax using a PEGylated lipid nano vehicle with a variety of proprietary alterations. I wanted to toy with these ideas til I realized the potential danger involved and stopped. Adding sodium hydroxide to solutions will increase the ph to high levels, so please give me a better than word for a solution that’s semi buffered. There is absolutely some kind of buffering occurring there because the solution is more resistant to ph changes than it is if you just adjust the ph up without anything acidic. I didn’t claim it was a great buffer but I didn’t think it mattered much. And I don’t care about ph buffers at all either. You are specifically looking for things to poke holes in. I’ve stated multiple times that ph is completely irrelevant to potency from what I’ve seen. Modifying it just has some interesting effects. I think you should experience the magic of this formula for yourself and then use your extensive knowledge to repost everything in a much better format. I didn’t even finish high school and I don’t, nor ever have, worked anywhere near the scientific industry. I don’t care about jargon and ultra detailed terminology. What I care about is winning the race. Making a working product was the goal and i succeeded and am now trying to teach it in the best way i know possible. I think it’s cool that I’m sharing this stuff for free rather than just using it get myself wealthy. You can dissect things all you want but I’d prefer if you DM me for semantics debates rather than dilute the transmission of applicable knowledge in the public space. Also, some of these concepts are massive and would require hundreds of pages of reading to grasp for the general public. So I’m trying not to go into every rabbit hole just yet. That doesn’t imply I’m attempting to mislead anyone, questions and patience will get my explanations faster than any other method. I understand your desire to defend the community against improper grammar, but please point it at someone with negative intentions. I’m just here to teach what I know
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Is that not how knowledge is advanced?
Not here to “grade your grammar”. You got the concept wrong. Why? Do you understand the concept when it is explained. evaluating your use of chemistry specific vocabulary is absolutely relevant to understanding your posts.
Were I here to grade your grammar, I fail to see how your intentions are relevant.
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Absolutely. I just gotta have some breathing room. I am not ready for the full shark tank experience yet, lol. I need to crowdsource the fine details of this thing so I expect lots of blanks to be filled in. But I don’t want the core principles to get lost before they are explored. I still have lots of questions myself that need to be answered about how and why this stuff works. It’s a pretty mindblowing thing to me and I mainly built it through excessive trial and error. I didn’t use the scientific method very well here. I kind of accidentally discovered this path while just trying to make slightly stronger edibles. Call me crazy but I feel like something put these ideas in my head and I’ve been trying to sort them all out for years myself
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