So, I am a quick learner and have finished pesticide remediation R&D with the chemists today. I have all tomorrow to talk and work with them. We will be looking at how high we can load the magsil/florisil pr columns I packed. I am still deciding if we will be going with silica or magsil. I have quite a few clients/friends wanting larger scale-outs of these purification systems. In about 2-3 weeks I will have a solid answer as we will be optimizing our purification strategy/method/gradients. This works to clean the pesticides, and does it super freaking quickly. If I load a 60 gram florisil column with 60 grams of extract, I can flash it in about 5-8 min max. We can easily scale this once we have the optimizations done.
Still looking at larger columns, I discussed the idea with Biotage today, and got the run down on their FLASH 150/400 systems (ideal for mostly reverse phase cannabinoid isolation, leading to isolate). We talked about columns for pesticide remediation, and its a tough one. Either I go with re-packable GE or PALL columns (like $20K for a good sized one), or I take a chance at designing my own. I cant find a way to ensure the pressure is evenly distributed in the column. Work in the lab today led to some channeling during a test, and I would like to avoid that at the large scale.
If anyone has any questions about advanced chromatography topics they can think to ask, please let me know! I still have full access to these chemists tomorrow, and don’t mind asking if its pertinent to our work.