Thanks so i can use this emulsifier
What is a spray dryer? is that really needed is there no easy way to make into powder ?
A spray dryer has hot air blowing through a glass or steel chamber and through some pipes. The liquid to be dried is sprayed into the heated chamber as a mist and dries in the air. This is one of the easiest, fastest, and cheapest ways to turn liquids into powders but not the only way.
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15 to 30 hours thats really long!
Iāve engineered the shit out of this, itās basically watt hr/L, the less you have to emulsify, the less time it takes.
Embarking on my nano learning journey, I recently acquired a Hielscher 400 and nano emulsion from Cannasol Technologies. After crafting my inaugural batch, I noticed that the color of the end product remains a slightly opaque, light milky hue.
In my calculations, Iāve determined that thereās approximately 30mg of active ingredient per 1ml of the emulsion. However, as I delve deeper into the science behind nano emulsions, Iāve come across information suggesting that they boast an absorption rate of around 80%, compared to the mere 20% absorption rate of regular oil.
Given this significant variance, I find myself pondering whether this means that nano emulsions could potentially deliver a fourfold stronger effect compared to traditional oils.
As I navigate through this fascinating realm of nanotechnology and its implications on cannabis formulation, I remain curious and eager to further explore the intricacies of this innovative approach.
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Iāve seen the many papers asserting as much, but I canāt say my personal experience has confirmed it. I will say that nano-emulsion based products do seem to kick in faster. Of course thereās always the possibility we just arenāt getting a low enough particle size for the benefits to really start accruing. @Photon_noir once told me he expected big changes in absorption below 20 nm, which I donāt know any commercial products achieving with ultrasonic.
I wonder if the watersolubility can be increased with a ph swing with argenine
Wich is a pretty strong base
@moronnabis @Lincoln20XX
Think argenine can hit 9.6ph
https://www.chem.ucalgary.ca/courses/350/Carey5th/Ch27/ch27-1-4-2.html
If you look at this chart of amino acidsā¦you will see that the amino acids have multiple Hydrogens that can be disassociated in aqueous solution.
Arginine carries not only the amino group one carbon away from the carboxylic acid (intramolecular zwitter ion complex)
Which will act as a buffer, it also has the guanidino group which acts as an acid at higher pH, 10-12, also creating an .extended buffer in this range. Also lookup solutions of guanidine HCL. The pH of 1.0 M arginine in water will be like 6-7. And it will act as a buffer.
So I do not think that will do the trick for you as a base.
Are you looking for an edible counter ion to make a salt ?
You phrased the question as if you wanted to use it as a base to deprotonate the cannabinotes for increased solubility. If you just want to deprotonate the carboxylic acid
Arginine may well be a suitable buffer at pH 6.5 in aqueous media. However, the more enhanced solubilities are achieved deprotonating at higher pH values to produce the phenolates. It is a bag of tricks.
If you were starting with a base solution of Cannabinoates to begin with, It might be worth while to āacidifyā with 0.5 M arginine if you were hoping for a complex with the guanidino groupā¦the zwitterion should take care of itself???
Edible salt, but probably not smokable.
Hopefully this answers your question.
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Looks like moronnabis already gave good input on the argenine part of the Q.
Iāve never thought about using pH to enhance solubility, but Iād be shocked if one couldnāt make it work.
The problem from a commercial standpoint is long-term stability of the product, which I think would be the biggest hurdle. I could very easily make you something that has all of the acidic cannabinoids in solution today, but by the time you bottle it and get it to a customer - regardless of final pH - itās definitely not going to have the same form and function as what was put in the bottle.
I presume someone who is more into the marketing side of things could probably spin that into a feature, but it sure looks like a bug from where I sit.
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Keep in mind pH of a water based product will also influence itās shelf life.
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when I was going down the nano rabbit hole doing r&d, we were testing shelf life of our finished drink product and we ended up having zero samples spoil, regardless of storage environment. hell we even left a few bottles outside in the elements over a hot summer and I think that bottle is still sitting in my buddies shed somewhereā¦
I am assuming the fact that we had next to zero natural ingredients in there outside of the carrier oil, natural coloring and natural flavoring extracts that it helped increase the shelf lifeā¦
fascinating tech but I think itās more suited for balms, lotions, topicals, etc.
in my opinion the onset is definitely faster than other edibles but that is because your body isnāt processing it as it does standard edibles, your high is closer to a smoke high as the nano encapsulated THC bypasses the liver entirely and so Iād run with the assumption that smaller nano encapsulation sizes would āincreaseā potency and onset too.
also pay attention to your nano machine and replace your horn or tip or whatever itās called as needed, it is crazy how fast the process can wear down and strip the metal away from the probe portion that agitates the solution!
i would like to buy a non emulsion machine if you still work for the company mentioned reach out