There is real science out there, that however is far from it. I’m not saying that cannabis cannot cause cardiac events in those without predisposition to them. I am suggesting that there is a lot of bullshit out there masked as information. I would go as far as to say that the odds of a fatal cardiac event in someone with no predisposition, and singularly linked to cannabis use, are far lower than hitting the mega millions lottery.
What??!
What are you talking about?
What spine?
With synthetics you mean D8 and D9 that come from an isomerization?
The difference is that everyone knows a gun kills ( and it’s done ONLY for that propose) almost all here are we now learning that cannabis has a LD50, and still plenty of us that we still unsure about this thing. The mom was also sure you can’t die from cannabis. So I think that a gun it’s not a good comparison.
Blood analysis says delta 9… not 11-hydroxy but delta 9.
Edit: nevermind that wasn’t the kid
Exactly.
Then again… A majority of people on here are not in laboratory settings and are making their own hash oils so I guess it depends on the context.
AP 10/21/22 update on the “STORY”
https://www.usnews.com/news/us/articles/2022-10-21/officials-virginia-mom-charged-in-sons-thc-gummy-death
Please read this updated story.
Referring to “”court records””
Here they say he was “unresponsive” on the day he arrived and died two days later.
She says “one” CBD gummy was in jar.
Supposedly the tox screen says D8 was found .
Again according to yesterdays update…so this is a “moving target” story
With what seems to be changing landscape of information.
We might have to leave the rest to the D8 synthesis boys…
Who knows what is in those batches?
If the boy ate the gummies…it may take about an hour or two before he was
“Unresponsive”…on day one. Two days later he passed.
“”She said the boy suffered from a “cardiac episode” and reported that it was determined her son “had something odd with his heart.””
When did they take the blood sample for tox screen.
2 days later??? Possible the boy had cardiac arrest day one, the revived his heart
But pulled the plug two days later. Maybe the cardiac arrest was associated with acute phase
Action of cannabinoid (one to two hr post ingestion).??
That is sad news, the mother should have acted when she saw the child in distress.
On the other hand did you read that tomy Chong cbd advertisement that was disguised as an article? He was talking about main lining cbd or some crazy shit.
I’m more talking about not isomerization but total synthesis. Conversions are technically semi synthetic. Pharmaceutical companies can’t patent a molecule unless they make it from scratch.
Looks like this may have been D8 as well.
That’s the same story as the original post, someone reached out to the police to clarify that it was Delta 8 since the first one was published
Love to see the actual tox screen report
yes, I read a study once saying that Dronabinol provoked seizures in rats. Maybe because of this?
Sidco: Perhaps the subject matter of Pediatric Myocarditis associated with Cannabinoid ingestion should be moved to a separate subject matter of its own.
Here is a case study…out of the Denver area (?) that involves the death of an 11 month old boy. The report is matter of fact and the association with Cannabinoic Acid is note worthy .
In this Case the Toxcitiy Screen revealed only THCA. Nothing else…and we can only summize the child ate a certain quantity of
Prepared “Diamonds”. In this thread we have been discussing the dubious nature of “death by THC ingestion”…which is warranted.
But for all who do not understand, the ingestion of large amounts
Of Cannabinoic Acids is Terra Incognito with regards to Toxicology. The predominate use of THCA and our experience of
THCA is one of vaping diamonds. This process decarbs a considerable quantity…so we are really not that familiar with the
Effects of blood levels of THCA. THCA and CBDA and their corresponding 3,’ three carbon analogues have very complex
Interactions with CB1 and CB2 receptors, and pronounced
“Aspirin”-like effects due to the Salicylic acid moiety.
These compounds exhibit pronounced physiological effects
And their toxicity is unknown. Based on this report no one should allow children near THCA (diamonds)… and with an abundance of caution the label should state such. If a child were to eat a single large Diamond…that is actually quite a dose of THCA. We have a unique situation here where the industry is a bit ahead of medical science.
If everyone gets on board here …please.
Below is the title and abstract…but the full article can be easily downloaded.
Pediatric Death Due to Myocarditis After Exposure to Cannabis
Thomas M. Nappe, DO* and Christopher O. Hoyte, MD*†
Author information Article notes Copyright and License information Disclaimer
Abstract
Since marijuana legalization, pediatric exposures to cannabis have increased.1 To date, pediatric deaths from cannabis exposure have not been reported. The authors report an 11-month-old male who, following cannabis exposure, presented with central nervous system depression after seizure, and progressed to cardiac arrest and died. Myocarditis was diagnosed post-mortem and cannabis exposure was confirmed. Given the temporal relationship of these two rare occurrences – cannabis exposure and sudden death secondary to myocarditis in an 11-month-old – as well as histological consistency with drug-induced myocarditis without confirmed alternate causes, and prior reported cases of cannabis-associated myocarditis, a possible relationship exists between cannabis exposure in this child and myocarditis leading to death. In areas where marijuana is commercially available or decriminalized, the authors urge clinicians to preventively counsel parents and to include cannabis exposure in the differential diagnosis of patients presenting with myocarditis.
“”Toxicology screening revealed urine enzyme-linked immunosorbent assay positive for tetrahydrocannabinol-carboxylic acid (THC-COOH) and undetectable serum acetaminophen and salicylate concentrations. Route and timing of exposure to cannabis were unknown.””
“” Post-mortem cardiac blood analysis confirmed the presence of Δ-9-carboxy-tetrahydrocannabinol (Δ-9-carboxy-THC) at a concentration of 7.8 ng/mL. Additional history disclosed an unstable motel-living situation and parental admission of drug possession, including cannabis.””
We assume the post-mortem was GC or GCMS so the THCA levels were measured as THC. (Unknown)
Now the myocarditis is due to an Immune response and the is the causative agent for the rather bizarre ECG presented in this paper. Can THCA trigger this immune response?
@ Rioplex…can you advise here?
Sidco…thanks if you can get this moved over…I have no idea how to do this.
We’re looking for a mod to start a new thread. @Akoyeh @FicklePickle @Killa12345 TIA
I wonder if ELIZA differentiates at all between 11-OH and d9? Wouldn’t it depend on binding site with the Eliza probe (promiscuity)?
Edit: I guess they say blood work showed d9 but it doesn’t say method
Well the question of distinction between the Cannabinoic Acids and the neutral cannabinoids is one question, and in the neutral realm whether their
Immunosorbant distinguishes between D9 and 11-0H is another. It all depends on the choice of cross linking methodology for the cross-linked antigen and whether you prepare a monoclonal or polyclonal. This particular assay they refer to I have no idea. My interpretation is that the tox screen for THCA was specific and the post Mortem determination was GCMS. Which decarbs in the injection port…so the
Report says D9.
Article says mother bought the edibles “from a Fredericksburg store”, clearly doesn’t sound like a dispensary. Would be very interested to see the actual bottle of these gummies, and see what unregulated gas station edibles we’re talking about here.
My local head shop must have 40 different varieties of delta 8 edibles, imagine sending in a bag of each to get tested and see what kind of nonsense ends up in those.
Turns out something to that effect was recently published…
From puking while sleeping from to much thc Ppl and animal vomit and it enters lungs. Sad.
Oh wow, ask and I shall receive huh. Seems that article is for the D8 vapes, but finds a list of unintended byproducts without even getting into the nasty shit they’ll cut those with for viscosity.
I’m all for more access to people in states with draconian weed laws, but there’s gotta be some better route than gas station drugs.