you’re distilling. which is going from liquid to vapor and back to liquid again.
can you offer any explanation for how removing solids would affect the final composition of the distillate?
you’re doing a fractional distillation. what might be going on here that could be improved?
you can certainly get ahead of the game by deliberately targeting specific non-target molecules, but simply filtering for the sake of filtration is not going to get you very far until you get down into the range of things that might legitimately co-distill or interfere with your distillation. things in the kiloDalton range… Your target is about 1/3 of a kDa.
What is a KD (kiloDalton)? - AISIMO CORPORATION
KD, or kD is the abbreviation for kiloDalton and is equal to 1,000 Molecular Weight Cut-> Of(MWCO). A solution having a molecular weight
of 1,000,000 would be equivalent to 1,000 KD. The table listed below gives a general relationship between kiloDalton to Microns
(micrometers), Nanometers, and Angstroms:KD’s Microns Nanometers Angstroms
1,000 KD 0.1 micron 100 1000
500 KD 0.02 micron 20 200
200 KD 0.01 micron 10 100
50 KD 0.004 micron 4 40
10 KD 0.0025 micron 2.5 25
5 KD 0.0015 micron 1.5 15As a general rule, choose a membrane with a pore size (MWCO) that is less than half of the compound of interest.
you can use , Winterization , Degumming, or LLE (or all three. see @Mcfly) to remove non-target before hitting the boiling flask.
if your decarb or devol were lacking, or you can’t tell your heads from your tails, then you’ll end up with more non-target in you final product.