Oh man guys! I’m so sorry. I sent this note last night after getting lost in the Echo Chamber for like an hour and I totally thought I linked to all the sources like I normally do! Rolling out a new inventory system at work and its got me bogged down, just came up for air and come back to all these questions!
Here’s the links to the academic studies 1, 2 - (yo, they have been doing this work for over 60 years! its not new science… its just science). Some in animals. Some in humans - the human work always seems to draw more attention…but we are not generally in the habit of forcing so much of any substance into a human until it kills him. Instead we use animals studies and wait for the Darwin effect to show us humans dying of something and then correlate with other available information. You know?
Here’s the link to the national poison control website - everyone should probably already know how to use this…so you can teach your mom. Its easy and has good info. And it has links to the big study of all poison related cases that have been submitted (it comes out every year) and was I’m referring to when I talk about harm reduction activities. Cool thing here - they actually have a fully separate category for THC that is not d9THC called THC homolog - for all those synthetics out there and other unknowns that people like to ingest.
I see people are looking at some WHO stuff and what not in the thread. Its probably worthwhile to show the DEA’s stance on THC toxicity - it also links directly to the references…if people were so inclined to read them. In summary - they agree that its nearly impossible to kill someone with d9THC - as a person would have to physically consume more than is possible to be consumed (aka it must crush them to kill them). This work is still from the 70’s and was part of Nixon’s war on drugs… so you know, read the references in that light. They were trying to prove that it will kill you, but could not. x.X
Here’s a link to a solid outline of acute toxicity and the references to the studies - also available publicly - no paywall or anything like that. And here’s the same thing for D9 - its even got a specific case listed of someone INJECTING over 2grams into their bloodstream, and then you know…dying. Not sure why you would do that. But its a known case of intravenous overdose.
I think the references above should probably help those that are looking to find more information from themselves. Certainly I was feeling a bit strange last night (doesn’t everyone who accidentally falls into the echo chamber?) but I’ve also just come from writing a couple papers on this stuff - you know?
The bigger thing for me is the known impurities and metabolites of those impurities which Mecholeum has legit been studying since the 70’s that people are all like - we never seen this before. Nah dude - we seen it. We even tried to kill animals with it. We have liver studies about it. And people decided back then it wasn’t worth pursuing, cause its wasn’t as effective as D9 for most things, and it had metabolites that made people sick.
When I say sick I mean getting the runs and stuff - not dying. And that’s the same thing we are seeing now. We’re seeing kids get sick - probably from a combination of too much sucralose or other sweeteners and D8 in their systems.
And kids getting sick is bad news bears for the industry as a whole. Cause when kids get sick - regulators take action. And when regulators take action then the enforcers start showing up to seize your stuff and/or collect taxes.
But I digress - so sorry I didn’t include the links. I don’t usually do this stuff from my phone while watching football in the dark.
Yo bro! Sorry I didn’t post the link last night. It is now linked above. One must dig for it and it is definitely available through scihub, you just have to poke it with the DOI correctly.
I think the WHO study is really weird - since it is almost exactly the opposite of the reported information from the other sources I have linked above. However - they have been known to selectively choose only the worst outcomes/studies when trying to tell people why drugs are terrible and should continue to be illegal. Kind of like the DEA study which shows that THC is basically heroin and even though it won’t kill you will ruin your life and your mom’s life too. (no really…you gotta read the study above they go completely down the rabbit hole on this one…)
I also find this stuff interesting - there is a further study that talks about cardiovascular issues - which points to this being caused by a metabolite that only forms from D8 liver metabolism. Its by that same Yoshimura lab - he really does a lot of excellent toxicology work and really tries hard to kill as many animals as possible in unique ways.
I mean I hate it… but would we have this information if we weren’t getting livers from dead people and killing off animals? Probably not.
All studies are relevant! That was the point of my post. That the studies exist. That we just need to spend the time to read them. And that we don’t have to wonder about this stuff because the science has been completed over the last 60 years or so.
I propose that the specific study you reference may not be relevant to humans - because a similar study performed in primates and another one in humans showed that there was not an LD50.
And that the studies that I linked above about D8 are specific to how the metabolism of D8 is what leads to issues (which others have shared other links about). And its those things, plus impurities from synthesis (those are also included in the links) that can also contribute to issues with GI tract bleeding and respiratory distress.
Yes - I’m referencing this database. And if you don’t have access to it directly - you can usually get all the other important information from PubChem and links to the studies where the data came from. I included links for this above. And you can always look on SDS for this information as well. And if you don’t have any SDS you can poke the European Toxicology Index.