The C.R.V. is here! Lets talk Agitation

[Krative]

Have you accomplished isolation at scale without distillation?

[Shadownaught]

Its not part of our current SOP due to the fact that the senior partners spent a bunch of money on a WFE and don’t want to see it sit around, but we do distillate free isolation on a smaller scale occaisionally. I only bring this up as an R&D project for others to scale up on their own.

Some CO2 expanded ethanol extraction systems do this with highly selective filtration before removing CO2.

[Kingofthekush420]

@Shadownaught

What I’m saying only really applies to hemp where thc ratios never represent enough of the solution to stop crystallization. What is really helping crystallization is the removal of heavy contaminants like lipids, flavonoids, carbs, etc.

Like in my example, if your crude CBD ratio goes from 65% to 80%, you arent expecting THC to affect crystallization in an appreciable way beyond what a detailed first pass would do.

You’re missing what I’m saying

There comes a point where THC and impurities WILL inhibit your crystal growth.

You’re saying this can replace distillation and it cant if you care about yields.

If you take your 80% TAC “crude” and run it though 1 pass of distillation itll probably put you above 95%

95% TAC will produce alot more isolate than 80% TAC

Theres a point where your impurities prevent crystallization so higher purity = higher yield

Also

Let’s say you’re doing chromatography to remediate thc from your left over mother liquor, not distilling will cost you more as you’ll have a less pure product to start there for costing you more media to do the same amount of work.

[Krative]

Distillation won’t make it easier to separate cannabinoids during chromatography, but it would make it easier to take out everything else. What if you want from CRC to a mediocre chromatography column? Is think that would reach above standard distillate potency.

[Krative]

That doesn’t change the current simplicity of purification by distillation though

[Kingofthekush420]

@Krative

Distillation won’t make it easier to separate cannabinoids during chromatography,

I’m not saying it makes it easier, it makes it more efficient.

If you have cbd at 80% TAC and crystallize it your isolate yield will be worse than it you started with better material ( like 95% TAC)

This leaves more things behind in the mother liquor requiring more work and media to do remediation.

Let’s break the math down

1 kg 80% TAC —> yields 70% (this is just a guess) this leaves 300 grams in the ML

1 KG 95% TAC —> yields 80% ( this is just a guess again)
Leaves 200 grams in the mother liquir.

If you use 1:1 mother liquor to chromatography media you’ll get 5 batches of mother liquor remediated with the 95% potency vs 3.33 of the other.

Maybe I’m tripping though.

I dont see how removing such an easy step to get such high purity could ever be worth it

I personally think starting with the highest quality product before isolation is key to yields,

Adding CRC into your SOP will definely improve purity, color and yields. I dont think it can replace distillation though.

[ScoobyDoobie]

I wonder what pressure’s influence on the isomerization reaction is. I wonder if the effect is comparable to the influence heat has the reaction.

Is pressurizing the cannabinoids in the presence of low/no heat but high pressure going to cause isomerization of the cannabinoids?

[Krative]

Has anybody played around with on-line isomerization?

[Soxhlet]

Like in a reactor?

[Krative]

Yes sir

[Soxhlet]

Should be no problem, as long as the correct acidic conditions and heat requirements are met for the conversion.It is probably a more ideal environment than a short path.
Where you ats’ @QGA !

[Waxplug1]

So…is nitrogen adsorbable?
I’ve noticed when I agitate with nitrogen I get more color…I’m guessing the nitrogen is taking up adsorbtion spots… could this be?

[Krative]

Nitrogen is completely inert and should not be bonding with anything afaik. @MagisterChemist @anon93688
Being that t-5 is coated in negative charges with hydrogen’s on them and b80 is covered in carboxylic acids, could nitrogen gas interact with these sites under the range of conditions: 0 psi to 300 psi, -100°C to 100°C

[Apothecary36]

Distillate sux. Of course crc will replace distillation. Disty smokers

[SettinguoalabinMD]

Sweet reactor!

Falling Formulations has 45 gallon setups for 5k!!!

I Got two from them!

They also have a plug on the motor I believe

I just didn’t have a use fer it

I asked if they can do filter drain on the bottom. For crystallization reactors, and that was a big yes as well!

[Waxplug1]

The reason I bring this up is because I noticed more color with agitation from nitrogen…then I saw a video claiming certain adsorbents like silica and carbon can adsorb nitrogen. I’m just trying to figure out why I get more color using nitro. Also noticed nitro moves slower through the powders

[Kingofthekush420]

@Apothecary36

Distillate sux. Of course crc will replace distillation. Disty smokers

With the new membrane tech coming out you’ll be able to seperate terpenes out of your crude before you distill it.

Distillate will never to away

[Apothecary36]

Neither will McDonald’s.

I’m not hating on the hustlers making money just the idea of being on a deserted island and only having distilled oil and botanical terpenes sounds lame to me.

I guess I could start infusing my crc stuff with distillate for carts but at that point why not just go full crc @StoneD seems to have had some success and that is much more appealing to me. The only reason I’d add distillate is to lower the price point

[Krative]

Has anyone tried percolating CO2 into a vessel with cannabinoids in a hydrocarbon?

[Waxplug1]

What reaction would the co2 cause?