I think the Farm Bill being an act of Congress ,signed, and inacted created
a de facto “grey area” when it comes to the “all derivatives” clause.
Make what you like according to State laws…if possible.
Now when you move your goodies over a State line…i.e., the Interstate Transport
of such and such…or claiming your goodie is a food product and not plywood glue…
I think one “may” run into a little darker grey area.
They don’t have to come to get you…they can flip the switch at your bank…tell you to drop by with your lawyer at your convenience.
4 Likes
Approximately 10 months ago China banned all synthetic cannabinoids. In my experience, when this happens production shifts to other countries or stops completely. Chinese exporters don’t appear to care about the legality of their exports in their customer’s country, but they do appear to be quite mindful of their own drug laws for the most part.
4 Likes
On the 1 of July all synthetic cannabinoids where illegalized so they now send two chemical compounds that usually only need a one step synthesis and cleanup to become a noid laws are pretty useless for this
Legalization is THE answer it really is
Laos will be the next producer not sure why India didn’t pick up space in the void
9 Likes
Haven’t been following things as closely as I used to, thanks for the update. They are definitely always quick with a work around though.
1 Like
They might have been banned 10 months ago but if you get on the onion, they are still being advertised by Chinese companies. There doesn’t seem to he a scarcity of RC cannabinoid. From my understanding, the Chineses government will change laws to appease the rest of the world but they don’t really enforce the laws.
1 Like
Always has been.
The difference being in China, when they decide to enforce those laws people get executed.
6 Likes
It was my understanding that the same enzyme was responsible for CBGa>THCa as well as CBGa>CBDa, which is neat. I’m curious if this understanding has changed in the five or so years since someone presented on the promiscuous enzyme at emerald. Always wondered what the relevant mechanic was for strain ratios was if it’s actually the case
At this year’s emerald someone mentioned it was 2 different enzymes fueling 2 different pathways from CBGa to THCa and CBDa. Hence why high CBD plants generally have low THC and vice versa. There was also a good presentation on terpene synthesis and the chirality of most of them (like R/S-limonene).
2 Likes
I wouldn’t expect one enzyme to use the same substrate to make two different products
Try looking up the concept of photorespiration. Oxygen competes with CO2 at the point of carbon fixation. One enzyme (RUBISCO), two possible products, depending on concentration of those gases.
1 Like
“Same” enzyme from an evolutionary point of view.
Duplication then divergence.
Possibly even “same” from a genomic location point of view. ie “allelic”.
Except we seem to have selected for additional rearrangements and duplications in the last couple of thousand years (which makes “allelic” somewhat complicated) is my take on it without diving into the primary sequence data or (re) reading the relevant publications.
From a biochemical standpoint, they are essentially identical (84% aa identity), and can both perform both conversations depending on reaction conditions.
this may provide more insight: Sequence heterogeneity of cannabidiolic- and tetrahydrocannabinolic acid-synthase in Cannabis sativa L. and its relationship with chemical phenotype - ScienceDirect
The amount of variation was found to be higher within the CBDAS sequence family than in the THCAS family, suggesting a more recent evolution of THCA-forming enzymes from the CBDAS group. We therefore consider CBDAS as the ancestral type of these synthases.
It has been previously proposed that the genes coding for the functional THCA- and CBDA-synthase (indicated as BT and BD) were allelic and codominant, and that the CBDA/THCA ratio of the heterozygous plants was invariably close to unity, due to the inher- ent kinetic properties of the two synthases simultaneously present in the BD/BT genotypes. This has been demonstrated by genetic analysis in THCA vs. CBDA scatter plots of heterozygous plants (de Meijer et al., 2003).
[…snip…]
Following these works, the genetics behind the main known Cannabis chemotypes, has been largely elucidated (de Meijer et al., 2003; Mandolino et al., 2003; de Meijer and Hammond, 2005; de Meijer et al., 2009a,b). In the current model, THCA- and CBDA-synthases are coded for by two alleles, BT and BD, but it is hypothesized that allelic and/or non-allelic variations may exist and explain the chemotype variation present in Cannabis germ- plasm.
12 Likes
thank you
1 Like
There are three relevant synthases; THCa synthase, CBDa synthase, and CBCa synthase. Each using CBGa as substrate.
5 Likes
Interestingly, THCp was already researched as a JWH compound (JWH-091) although it has a wildly different structure than JWH-018. They’re both full agonists though which is the scary part imo.
1 Like
S0039914021006251(1).pdf (3.3 MB)
Here’s a paper on detecting thc p in biomass, thought some of you might enjoy
This one came out recently, there another I’m trying to find but I’m having problems getting access to acs
Can anyone help?
This is the paper I’m looking for
3 Likes
Do you have the doi?
I dont, the paper is on acs though as that’s where it’s published
1 Like
Here’s my spoon feed of the day for making THC-P from THC.
First Step: mCPBA epoxidation of the allylic system.
Step 2: a.) NBS Bromination of Benzylic position. b.) elimination of benzyl bromide to conjugated alkene. c.) allylic NBS bromination of alkene. d.) elimination of benzyl bromide to conjugated diene. e.) allylic NBS bromination of diene.
Step 3: Ethyl grignard of terminal allylic bromide.
Step 4: Reduction of diene via standard Pd/C/H2 reduction, while simultaneously reducing epoxide with a fancy Au system. Clean protocol for deoxygenation of epoxides to alkenes via catalytic hydrogenation using gold - Catalysis Science & Technology (RSC Publishing)
6 Likes