Journal of American Chemical Society
search term “cannabinoid”
The Isolation and Structure of A ^Tetrahydrocannabinol and Other Neutral Cannabinoids from Hashish Volume 93 Issue 1
The Isolation and Structure of A ^Tetrahydrocannabinol and.pdf (239.4 KB)
Structural Studies of Cannabinoids. A Theoretical and Proton Magnetic Resonance Analysis Volume 92 Issue 17
Structural Studies of Cannabinoids. A Theoretical and Proton Magnetic Resonance Analysis.pdf (208.6 KB)
Syntheses of A^Tetrahydrocannabinol and Related Cannabinoids Volume 94 Issue 17
Syntheses of A^Tetrahydrocannabinol and Related Cannabinoids.pdf (226.6 KB)
Synthesis and Enzymatic Formation of a C-Glucuronide of A6-Tetrahydrocannabinol Volume 99 Issue 19
Synthesis and Enzymatic Formation of a C-Glucuronide of A6-Tetrahydrocannabinol.pdf (112.6 KB)
Carbon-Phosphorus Heterocycles. Synthesis of Phosphorus-Containing Cannabinoid Precursors and a Single-Crystal Analysis of l,2,3,4-Tetrahydro-10-hydroxy-8-rt-pentyl-5i/-phosphorino[3,4-c][ 1 ]benzopyran-5-one 3-Oxide Volume 103 Issue 8
Synthesis of Phosphorus-Containing Cannabinoid Precursors.pdf (163.4 KB)
Identification of A ^Tetrahydrocannabinol and Metabolites in Man Volume 94 Issue 24
Identification of A ^Tetrahydrocannabinol and Metabolites in Man.pdf (103.9 KB)
Isolation, Structure, and Biological Activity of Several Metabolites of A9-Tetrahydrocannabinol Volume 92 Issue 11
Isolation, Structure, and Biological Activity of Several Metabolites of A9-Tetrahydrocannabinol.pdf (100.2 KB)
Synthesis and Biological Activity of Five Tetrahydrocannabinol Metabolites Volume 94 Issue 22
Synthesis and Biological Activity of Five Tetrahydrocannabinol Metabolites.pdf (76.3 KB)
Hashish, a Novel Cannabinoid Containing a Cyclic Peroxide Volume 91 Issue 18
Hashish, a Novel Cannabinoid Containing a Cyclic Peroxide.pdf (71.7 KB)
Hashish.1 A Simple One-Step Synthesis of ( — ^^Tetrahydrocannabinol (THC) from />-Mentha-2,8-dien-l-ol and Olivetol Volume 96 Issue 18
Hashish.1 A Simple One-Step Synthesis.pdf (175.8 KB)
Stereospecific Intramolecular Epoxide Cleavage by Phenolate Anion. Synthesis of Novel and Biologically Active Cannabinoids Volume 96 Issue 23
Stereospecific Intramolecular Epoxide Cleavage by Phenolate Anion.pdf (103.5 KB)
A Terpenic Synthon for A’-Cannabinoids1 Volume 100 Issue 9
A Terpenic Synthon for A’-Cannabinoids1.pdf (101.5 KB)
Total Synthesis of Anhydrocannabisativene Volume 106 Issue 11
Total Synthesis of Anhydrocannabisativene.pdf (212.2 KB)
Sulfones as Chemical Chameleons. Cyclization via 1,1-Dipole Synthons Volume 106 Issue 23
“Cannabinoid reference : The effect of the allyl substituents on the cyclization was also
examined in the context of a model toward cannabinoid metabolites.
9”
Sulfones as Chemical Chameleons…pdf (79.1 KB)
Cycloaddition Reactions of Silyloxyacetylenes with Ketenes: Synthesis of Cyclobutenones, esorcinols, and A-6-TetrahydrocannabinoI Volume 110 Issue 11
“Cannabinoid reference : In order to illustrate
this concept, we have applied the resorcinol chemistry described
above to preparation of the minor, physiologically active cannabinoid
isomer, A-6-tetrahydrocannabinol (11).”
Cycloaddition Reactions of Silyloxyacetylenes.pdf (111.5 KB)
Stereoelectronic Factor in the Chloranil Dehydrogenation of Cannabinoids. Total Synthesis of rfZ-Cannabichromene1,2 Volume 90 Issue 9
Stereoelectronic Factor in the Chloranil Dehydrogenation of Cannabinoids.pdf (70.7 KB)
Stereospecific Formation of 1,2-Dioxetanes from cis- and f/ww-Diethoxyethylenes by Singlet Oxygen Volume 92 Issue 10
"Cannabinoid reference : A similar band at 850 cm- 1 was ascribed to O-O stretch in a
cannabinoid dioxetane isolated by R. K. Razdan and V. V. Kane, /.
Amer. Chem. Soc, 91, 5190 (1969), footnote 5.
Stereospecific Formation of 1,2-Dioxetanes.pdf (101.3 KB)
Isolation, Structure, and Biological Activity of Several Metabolites of A9-Tetrahydrocannabinol Volume 92 Issue 11
Isolation, Structure, and Biological Activity of Several Metabolites of A9-Tetrahydrocannabinol.pdf (100.2 KB)
Hashish. A Stereospecific Synthesis of (—)-Aland (—)-A1 (6) -Tetrahydrocannabinols.pdf (98.1 KB) : Volume 92 Issue 20
Hashish.1 Synthesis of 7-Hydroxy-A ^tetrahydrocannabinol (THC). An Important Active Metabolite of A^THC in Man2
Hashish.1 Synthesis of 7-Hydroxy-A.pdf (101.3 KB)
Thermal Isomerization of Cannabinoid Analogues
Thermal Isomerization of Cannabinoid Analogues.pdf (100.3 KB)
Quasi-Atomistic Receptor Surface Models: A Bridge between 3-D QSAR and Receptor Modeling
"Cannabinoid Reference : Our
concept has been used to derive semiquantitative structure-activity relationships for the â2-adrenergic, aryl
hydrocarbon, cannabinoid, neurokinin-1, and sweet-taste receptor as well as for the enzyme carbonic anhydrase.
Quasi-Atomistic Receptor Surface Models.pdf (96.5 KB)
Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by r-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures
“Cannabinoid Reference : The cocrystal X-ray structures of two isomeric R-ketooxazole inhibitors (1 (OL-135) and 2) bound
to fatty acid amide hydrolase (FAAH), a key enzymatic regulator of endocannabinoid signaling, are disclosed”
Binding and Inactivation Mechanism of a Humanized Fatty Acid.pdf (531.7 KB)
Elucidation of Fatty Acid Amide Hydrolase Inhibition by Potent r-Ketoheterocycle Derivatives from Monte Carlo Simulations
“Cannabinoid Reference : Fatty acid amide hydrolase (FAAH) is a serine hydrolase responsible for the degradation of
anandamide, an endogenous cannabinoid agonist, and oleamide, a sleep-inducing lipid.”
Elucidation of Fatty Acid Amide Hydrolase Inhibition.pdf (642.7 KB)
The Putative Endocannabinoid Transport Blocker LY2183240 Is a Potent Inhibitor of FAAH and Several Other Brain Serine Hydrolases
The Putative Endocannabinoid Transport Blocker LY2183240.pdf (296.9 KB)
Elucidation of Hydrolysis Mechanisms for Fatty Acid Amide Hydrolase and Its Lys142Ala Variant via QM/MM Simulations
“Cannabinoid Reference : Fatty acid amide hydrolase (FAAH) is a serine hydrolase that degrades anandamide, an
endocannabinoid, and oleamide, a sleep-inducing lipid, and has potential applications as a therapeutic
target for neurological disorders”
Elucidation of Hydrolysis Mechanisms for Fatty Acid Amide Hydrolase.pdf (600.4 KB)
First Direct Evidence for the Mechanism of A’-Tetrahydrocannabinolic Acid Biosynthesis
First Direct Evidence for the Mechanism of A’-Tetrahydrocannabinolic Acid Biosynthesis.pdf (542.7 KB)
Antibody-Catalyzed Oxidation of ¢9-Tetrahydrocannabinol
Antibody-Catalyzed Oxidation of ¢9-Tetrahydrocannabinol.pdf (97.5 KB)
Activity-Based Probes That Target Functional Subclasses of Phospholipases in Proteomes
“Cannabinoid Reference : Phospholipases are a large and diverse set of enzymes that
metabolize the phospholipid components of cell membranes1,2 and
participate in key lipid-signaling pathways, such as those that
generate eicosanoids3 and endocannabinoids”
Activity-Based Probes That Target Functional Subclasses of Phospholipases in Proteomes.pdf (144.5 KB)
Functional GPCR Microarrays
“Cannabinoid Reference : We fabricated GPCR microarrays consisting of the neurotensin
receptor 1 (NTSR1),10 the cholinergic receptor muscarinic 2
(CHRM2),11 the opioid receptor mu (OPRM),12 and the cannabinoid
receptor 1 (CNR1).13”
Functional GPCR Microarrays.pdf (278.5 KB)
Delineation of a Fundamental r-Ketoheterocycle Substituent Effect for Use in the Design of Enzyme Inhibitors
“Cannabinoid Reference : Anandamide binds
and activates the central (CB1) and peripheral (CB2) cannabinoid
receptors where it has been implicated in the modulation of
nociception, feeding, and anxiety.”
Delineation of a Fundamental r-Ketoheterocycle.pdf (55.9 KB)
A Functional Proteomic Strategy to Discover Inhibitors for Uncharacterized Hydrolases
“Cannabinoid Reference : Carbamates have proven to be a versatile class of SH inhibitors,
with multiple agents in active clinical use or development, including
those that target the SHs acetylcholinesterase (AChE) and FAAH,9
which regulate acetylcholine and endocannabinoid signaling in the
nervous system, respectively. ABHD6 represented an attractive
initial target for competitive ABPP, as this enzyme, like AChE and
FAAH, is highly expressed in mammalian brain”
A Functional Proteomic Strategy to Discover Inhibitors for Uncharacterized Hydrolases.pdf (197.2 KB)
Traceless Stereoinduction in the One-Pot Assembly of All Three Rings of Hexahydrodibenzopyrans
"Cannabinoid Reference : The exo transition state is observed for the intramolecular Diels-Alder
reactions of metal-free o-quinone methides in the synthesis of hexahydrocannabinoids;
see ref 1, pp 5369-5370. "
Traceless Stereoinduction in the One-Pot Assembly of All Three Rings of Hexahydrodibenzopyrans.pdf (259.1 KB)
Small and Stable Sulfobetaine Zwitterionic Quantum Dots for Functional Live-Cell Imaging
"Cannabinoid Reference : We finally demonstrated the application of zwitterionic QDs-SA
as probes in a biological living system by specifically labeling the
cannabinoid receptor 1 (CB1R) and tracking its intracellular traffic. "
Small and Stable Sulfobetaine Zwitterionic Quantum Dots for Functional Live-Cell Imaging.pdf (94.9 KB)
Journal of Agricultural and Food Chemistry
Volume 1 - Volume 64 1953 - 2016
search term “cannabinoid”
Activity-Based Protein Profiling of Organophosphorus and Thiocarbamate Pesticides Reveals Multiple Serine Hydrolase Targets in Mouse Brain
“Cannabinoid Reference : enzymes involved in the degradation of endocannabinoid signaling
lipids, monoacylglycerol lipase, and fatty acid amide hydrolase were inhibited by several OP and TC pesticides.”
Activity-Based Protein Profiling of Organophosphorus and Thiocarbamate.pdf (1021.3 KB)
A Potential Target for Organophosphate Insecticides Leading to Spermatotoxicity
“Cannabinoid Reference : inhibition of fatty acid amide hydrolase (FAAH) in mouse testis
and epididymis cauda, to modulate the endocannabinoid
signaling, appears to be relevant to the OP-induced
spermatotoxicity.”
A Potential Target for Organophosphate Insecticides.pdf (153.2 KB)
Time-Resolved Fluoroimmunoassay for ¢9-Tetrahydrocannabinol As Applied to Early Discrimination of Cannabis sativa Plants
Time-Resolved Fluoroimmunoassay for ¢9-Tetrahydrocannabinol As Applied to Early Discrimination of Cannabis sativa Plants.pdf (37.1 KB)
Enrichment of Echinacea angustifolia with Bauer Alkylamide 11 and Bauer Ketone 23 Increased Anti-inflammatory Potential through Interference with COX-2 Enzyme Activity
“Cannabinoid Reference : These
studies have mainly focused on one particular class of compounds
of Echinacea, alkylamides, and their ability to interact with cannabinoid
receptors.”
Enrichment of Echinacea angustifolia with Bauer Alkylamide 11.pdf (961.6 KB)
Unsaturated Fatty Alcohol Derivatives of Olive Oil Phenolic Compounds with Potential Low-Density Lipoprotein (LDL) Antioxidant and Antiobesity Properties⊗
“Cannabinoid Reference : Some of them presented modulation of food intake in rats and,
due to their molecular similarity with CB1 endogenous ligands, the endocannabinoid system”
Unsaturated Fatty Alcohol Derivatives of Olive Oil Phenolic Compounds.pdf (191.5 KB)
Synthesis of Oleoylethanolamide Using Lipase
“Cannabinoid Reference " The scalability and ease for such synthesis make it possible to study the biological and nutritional functions of the
cannabinoid-like oleoylethanolamide in animal or human subjects.”
Synthesis of Oleoylethanolamide Using Lipase.pdf (292.2 KB)
Carbohydrate arid Cyclitol Content of Cannabis
Carbohydrate arid Cyclitol Content of Cannabis.pdf (145.9 KB)
Long-chain Hydrocarbons of Cannabis and Its Smoke
Long-chain Hydrocarbons of Cannabis and Its Smoke.pdf (75.2 KB)
Cannabis Smoke Condensate, Identification of Some Acids, Bases, and Phenols
Cannabis Smoke Condensate, Identification of Some Acids, Bases, and Phenols.pdf (2.3 MB)
Tetrahydro-â-carbolines, Potential Neuroactive Alkaloids, in Chocolate and Cocoa
“Cannabinoid Reference : Chocolate contains several biologically
active constituents (methylxanthines, biogenic amines,
and cannabinoid-like substances), all of which potentially
cause abnormal behavior and psychological sensation
that parallel those of other addictive substances
(Bruinsma and Taren, 1999). In this regard, this paper”
Tetrahydro-â-carbolines.pdf (73.6 KB)
Echinacea Species and Alkamides Inhibit Prostaglandin E2 Production in RAW264.7 Mouse Macrophage Cells
“Cannabinoid Reference : Alkamides may be best known through recent studies indicating
their ability to modulate the immune system, potentially, by
binding to the cannabinoid 2 receptor (CB2)”
Echinacea Species and Alkamides.pdf (484.2 KB)
Effects of Coffee Bean Aroma on the Rat Brain Stressed by Sleep Deprivation: A Selected Transcript- and 2D Gel-Based Proteome Analysis
“Cannabinoid Reference : Specific primers were designed to form the 3′-UTR regions
of each of the genes as described in Table 1. FBJ murine osteosarcoma
viral oncogene homologue (c-fos), early growth response 1 (egr-1), early
growth response 2 (egr-2), immediate early gene transcription factor
NGFI-B (NGFI-B), PP1 inhibitor 1 (Ppp1r1a), adenosine A2A receptor
(Adora2a), fast nerve growth factor receptor (NGFR), neurotrophic
tyrosine kinase, receptor, type 2 (trkB), neurotrophic tyrosine kinase,
receptor, type 3 (trkC), monoamine oxidase A (Maoa), glucocorticoidinduced
receptor (GIR), activity regulated cytoskeletal-associated protein
(Arc), 5HT3 receptor 5HT3 receptor, cannabinoid receptor 1 (brain)
(Cnr1), cholecystokinin 1 receptor (CCK1R), cholecystokinin 2 receptor
(CCK2R), and Jun oncogene (Jun) were obtained using the NCBInr
database search.”
(Poor fucking rats I wonder if they wrote that sentence when they were hanging for caffeine)
Effects of Coffee Bean Aroma on the Rat Brain Stressed by Sleep Deprivation.pdf (308.0 KB)
Protective Effects of the Essential Oil of Salvia fruticosa and Its Constituents on Astrocytic Susceptibility to Hydrogen Peroxide-Induced Cell Death
“Cannabinoid Reference : For example, trans-β-caryophyllene,
which is one of the components that penetrated
astrocytes, was shown to be a functional agonist of the cannabinoid
CB2 receptor, to inhibit adenylate cyclase activity, and to
attenuate the LPS-stimulated Erk1/2 and JNK1/2 phosphorylation”
Protective Effects of the Essential Oil of Salvia fruticosa.pdf (634.8 KB)
Endogenous Levels of Echinacea Alkylamides and Ketones Are Important Contributors to the Inhibition of Prostaglandin E2 and Nitric Oxide Production in Cultured Macrophages
“Cannabinoid Reference : Studies have further validated that alkylamides
are capable of binding to and activating the cannabinoid
receptor type 2, providing insight into the mechanism by which
these constituents may modulate immune function”
Endogenous Levels of Echinacea Alkylamides.pdf (763.9 KB)
Chemical Synthesis of 9(Z)-Octadecenamide and Its Hypolipidemic Effect: A Bioactive Agent Found in the Essential Oil of Mountain Celery Seeds
“Cannabinoid Reference : Psychiatrically, oleamide induced behaviors reminiscent
of the actions of endogenous cannabinoids, but the
GABAergic and dopaminergic systems, either directly or indirectly,
were considered to be crucially involved in the actions of
oleamide”
Chemical Synthesis of 9(Z)-Octadecenamide.pdf (743.0 KB)
Curious about Pesticide Action
“Cannabinoid Reference : OPs such
as CPO (bioactivated chlorpyrifos) (23) and IDFP (24) (model
compound) inhibit endocannabioid metabolism by monoacylglycerol
lipase and fatty acid amide hydrolase (FAAH), resulting
in elevated endocannabinoid levels of 2-arachidonoylglycerol and
anandamide, respectively, leading to OP-induced cannabinoid
effects.”
Curious about Pesticide Action.pdf (1.3 MB)
Identification and Quantification of Major Steviol Glycosides in Stevia rebaudiana Purified Extracts by 1H NMR Spectroscopy
“Cannabinoid Reference : Published qHNMR methods
which employ anthracene as IS include the determination of
ginkgolic acids in Ginkgo biloba16 and cannabinoids in Cannabis
sativa.17”
Identification and Quantification of Major Steviol Glycosides in Stevia.pdf (616.9 KB)
Analysis of Alkylamides in Echinacea Plant Materials and Dietary Supplements by Ultrafast Liquid Chromatography with Diode Array and Mass Spectrometric Detection
“Cannabinoid Reference : Alkylamides have been shown to induce anti-inflammatory
responses in mouse macrophages,11 interact with the endocannabinoid
system,12 and inhibit COX-2 activity,13 confirming the
in vitro effect of these compounds on immune response”
Analysis of Alkylamides in Echinacea Plant Materials and Dietary Supplements.pdf (633.8 KB)
Echinacea Alkamides Prevent Lipopolysaccharide/D-Galactosamine-Induced Acute Hepatic Injury through JNK Pathway-Mediated HO-1 Expression
“Cannabinoid Reference : Echinacea alkamides are some of the best
known herbal cannabinomimetics that can modulate the expression
of tumor necrosis factor α (TNF-α) via binding to cannabinoid
receptor 2 (CB2).”
Echinacea Alkamides Prevent Lipopolysaccharide.pdf (1.1 MB)
Characterization of Byproducts Originating from Hemp Oil Processing
Characterization of Byproducts Originating from Hemp Oil Processing.pdf (183.1 KB)
Modulation of the Intestinal Microbiota Is Associated with Lower Plasma Cholesterol and Weight Gain in Hamsters Fed Chardonnay Grape Seed Flour
“Cannabinoid Reference : Feeding of Akkermansia mucinphila (a mucin-degrading
bacterium) enhanced mucus thickness, intestinal endocannabinoid
production, and gut barrier function in mice on HF diets,
which resulted in reduced fat mass, endotoxemia, adipose tissue
inflammation, and insulin resistance.16”
Modulation of the Intestinal Microbiota Is Associated with Lower Plasma Cholesterol.pdf (234.7 KB)
Enhanced Production of Resveratrol, Piceatannol, Arachidin-1, and Arachidin‑3 in Hairy Root Cultures of Peanut Co-treated with Methyl Jasmonate and Cyclodextrin
“Cannabinoid Reference : Arachidin-1 and arachidin-3 have been shown to modulate
both cannabinoid receptors CB1 and CB2 in vitro.”
Enhanced Production of Resveratrol.pdf (294.8 KB)
Characterization of Lignanamides from Hemp (Cannabis sativa L.) Seed and Their Antioxidant and Acetylcholinesterase Inhibitory Activities
Characterization of Lignanamides from Hemp (Cannabis sativa L.) Seed.pdf (302.2 KB)
Effect of Increasing Doses of Linoleic and α‑Linolenic Acids on High-
Fructose and High-Fat Diet Induced Metabolic Syndrome in Rats
“Cannabinoid Reference : Reports indicated endocannabinoids 2-arachidonoylglycerol,
and anandamide related to appetite were improved in 8
energy-% LA rats (compared to 1 energy-% LA), resulting in a
higher adiposity.”
Effect of Increasing Doses of Linoleic and α‑Linolenic Acids.pdf (416.3 KB)
Structural Diversity and Biological Activities of Indole Diketopiperazine Alkaloids from Fungi
“Cannabinoid Reference : Amauromine 104 was first isolated from Amauroascus sp. in
1985107 and identified as a hypotensive vasodilator. Elsebai et
al. later isolated amauromine 104 from the fungus Auxarthron
reticulatum in 2011 and identified it as a selective cannabinoid
CB1 receptor antagonist.108 On the other hand, its stereoisomer
epiamauromine 105 showed insecticidal activity.16,109”
smokeable fungi man love it. hey bro that oil got me way to high can you pass me a mushroom.
Structural Diversity and Biological Activities of Indole.pdf (767.3 KB)
Chocolate and Other Cocoa Products: Effects on Human Reproduction and Pregnancy
“Cannabinoid Reference : Anandamide, an endogenous lipid belonging to the class of
endocannabinoids, acts as a cannabinoid receptor agonist,
mimicking the central and peripheral action of cannabinoids
such as Δ9-tetrahydrocannabinol (the active ingredient of
cannabis extracts).”
Chocolate and Other Cocoa Products Effects on Human Reproduction and Pregnancy.pdf (145.8 KB)
Ethylene Induced a High Accumulation of Dietary Isoflavones and Expression of Isoflavonoid Biosynthetic Genes in Soybean (Glycine max) Leaves
“Cannabinoid Reference : There is also a report that
ethephon, a source of ethylene, stimulates cannabinoid and
plastidial terpenoid production in Cannabis sativa during
flowering.7”
It is to be noted here that ethylene also increases the speed of many types fruit ripening and is one of the main reasons grapes are best not kept in bulk in commercial kitchen fridges, it makes all of your fruit and some vegetables go off quicker. It also leads me to believe that a large box of grapes in a domestic grow tent will make the flowers produce more cannibinoids and terpenes and come to maturity quicker in the later part of the flower cycle
Ethylene Induced a High Accumulation of Dietary Isoflavones.pdf (356.9 KB)
Natural Products with Anti-obesity Effects and Different Mechanisms of Action
“Cannabinoid Reference : Rimonabant is a
selective reverse agonist of the cannabinoid receptor type 1
(CB1) receptor, which increases during the differentiation of
pre-adipocytes and the biosynthesis of triacylglycerol (TG) and
fatty acid”
this paper later goes on to say that the reverse CB1 agonist has been known to induce suicide and depression in users.
Natural Products with Anti-obesity Effects and Different Mechanisms of Action.pdf (316.4 KB)
