Journal of Medicinal Chemistry
1951 - 2011
Characterization of a Region of Steric Interference at the Cannabinoid Receptor Using the Active Analog Approach1
Characterization of a Region of Steric Interference at the Cannabinoid Receptor.pdf (360.0 KB)
Aminoalkylindoles: Structure—Activity Relationships of Novel Cannabinoid Mimetics
Aminoalkylindoles Structure—Activity Relationships of Novel Cannabinoid.pdf (1.2 MB)
Derivation of a Pharmacophore Model for Anandamide Using Constrained Conformational Searching and Comparative Molecular Field Analysis
“Cannabinoid Reference: The proposed pharmacophore model was capable of discriminating between
structurally related compounds exhibiting different pharmacological potency for the CB1
cannabinoid receptor, i.e., anandamide and N-(2-hydroxyethyl)prostaglandinamide.”
Derivation of a Pharmacophore Model for Anandamide Using Constrained.pdf (254.2 KB)
Three-Dimensional Quantitative Structure-Activity Relationship Study of the Cannabimimetic (Aminoalkyl)indoles Using Comparative Molecular Field Analysis
Three-Dimensional Quantitative Structure-Activity Relationship Study of the spice.pdf (244.0 KB)
Structure-Activity Analysis of Anandamide Analogs: Relationship to a Cannabinoid Pharmacophore
Structure-Activity Analysis of Anandamide Analogs Relationship to a Cannabinoid Pharmacophore.pdf (371.8 KB)
(Aminoalkyl)indole Isothiocyanates as Potential Electrophilic Affinity Ligands for the Brain Cannabinoid Receptor
(Aminoalkyl)indole Isothiocyanates as Potential Electrophilic Affinity Ligands for the Brain Cannabinoid Receptor.pdf (266.4 KB)
5-Azido-A8-THC: A Novel Photoaffinity Label for the Cannabinoid Receptor
5-Azido-A8-THC A Novel Photoaffinity Label for the Cannabinoid Receptor.pdf (185.1 KB)
Synthesis and Pharmacological Comparison of Dimethylheptyl and Pentyl Analogs of Anandamide
Synthesis and Pharmacological Comparison of Dimethylheptyl and Pentyl Analogs of Anandamide.pdf (133.0 KB)
Classical/Nonclassical Hybrid Cannabinoids: Southern Aliphatic Chain-Functionalized C-6â Methyl, Ethyl, and Propyl Analogues
Classical Nonclassical Hybrid Cannabinoids Southern Aliphatic Chain - Functionalized c-6b Methyl, Ethyl, and Propyl Analogues.pdf (290.4 KB)
Importance of the C-1 Substituent in Classical Cannabinoids to CB2 Receptor Selectivity Synthesis and Characterization of a Series of O,2-Propano delta 8 tetrahydrocannabinol Analogs
Importance of the C-1 Substituent in Classical Cannabinoids to CB2 Receptor Selectivity Synthesis and Characterization of a Series of O,2-Propano delta 8 tetrahydrocannabinol Analogs.pdf (172.3 KB)
Cannabinol Derivatives: Binding to Cannabinoid Receptors and Inhibition of Adenylylcyclase
Cannabinol Derivatives Binding to Cannabinoid Receptors and Inhibition of Adenylylcyclase.pdf (216.7 KB)
Use of a Potential Rabbit Model for Structure-Behavioral Activity Studies of Cannabinoids
Use of a Potential Rabbit Model for Structure-Behavioral Activity Studies of Cannabinoids.pdf (134.1 KB)
The Importance of the Orientation of the C9 Substituent to Cannabinoid Activity
The Importance of the Orientation of the C9 Substituent to Cannabinoid Activity.pdf (170.7 KB)
(-)-ll-Hydroxy-7’-isothiocyanato-l’,l’-dimethylheptyl-A8-THC: A Novel, High-Affinity Irreversible Probe for the Cannabinoid Receptor in the Brain
Close your eyes, give me your hand
Do you feel my heart beating
Do you understand?
Do you feel the same
Am I only dreaming
Or is this binding an eternal stone?
of course the body adjusts but cool idea ha 
(-)-ll-Hydroxy-7’-isothiocyanato-l’,l’-dimethylheptyl-A8-THC A Novel, High-Affinity Irreversible Probe for the Cannabinoid Receptor in the Brain.pdf (118.0 KB)
Design, Synthesis and Biological Evaluation of Novel Arachidonic Acid Derivatives as Highly Potent and Selective Endocannabinoid Transporter Inhibitors
Design, Synthesis and Biological Evaluation of Novel Arachidonic Acid Derivatives as Highly Potent and Selective Endocannabinoid Transporter Inhibitors.pdf (48.8 KB)
Conformational Analysis of the Prototype Nonclassical Cannabinoid CP-47,497, Using 2D NMR and Computer Molecular Modeling
Conformational Analysis of the Prototype Nonclassical Cannabinoid CP-47,497, Using 2D NMR and Computer Molecular Modeling.pdf (801.7 KB)
Molar Volume Relationships and the Specific Inhibition of a Synaptosomal Enzyme by Psychoactive Cannabinoids
Molar Volume Relationships and the Specific Inhibition of a Synaptosomal Enzyme by Psychoactive Cannabinoids.pdf (180.5 KB)
Synthesis and Pharmacological Evaluation of Ether and Related Analogues of Delta 8 -,Delta 9 -, and Delta 9/11 Tetrahydrocannabinol
pass me the bottle of methyl iodide please sir
Synthesis and Pharmacological Evaluation of Ether and Related Analogues of A8-,A9-, and A91 ^Tetrahydrocannabinol.pdf (228.1 KB)
Conformationally Restrained Analogues of Pravadoline: Nanomolar Potent, Enantioselective, (Aminoalkyl)indole Agonists of the Cannabinoid Receptor
Conformationally Restrained Analogues of Pravadoline Nanomolar Potent, Enantioselective, (Aminoalkyl)indole Agonists of the Cannabinoid Receptor.pdf (398.2 KB)
(R)-Methanandamide: A Chiral Novel Anandamide Possessing Higher Potency and Metabolic Stability
(R)-Methanandamide A Chiral Novel Anandamide Possessing Higher Potency and Metabolic Stability.pdf (159.1 KB)
A Novel Probe for the Cannabinoid Receptor
A Novel Probe for the Cannabinoid Receptor.pdf (196.0 KB)
Synthesis and Pharmacology of a Very Potent Cannabinoid Lacking a Phenolic Hydroxyl with High Affinity for the CB2 Receptor
Synthesis and Pharmacology of a Very Potent Cannabinoid Lacking a Phenolic Hydroxyl with High Affinity for the CB2 Receptor.pdf (105.9 KB)
Structural Requirements for Binding of Anandamide-Type Compounds to the Brain Cannabinoid Receptor
Structural Requirements for Binding of Anandamide-Type Compounds to the Brain Cannabinoid Receptor.pdf (220.6 KB)
Synthetic Nonpsychotropic Cannabinoids with Potent Antiinflammatory, Analgesic, and Leukocyte Antiadhesion Activities
Synthetic Nonpsychotropic Cannabinoids with Potent Antiinflammatory, Analgesic, and Leukocyte Antiadhesion Activities.pdf (246.0 KB)
Head Group Analogs of Arachidonylethanolamide, the Endogenous Cannabinoid Ligand
Head Group Analogs of Arachidonylethanolamide, the Endogenous Cannabinoid Ligand.pdf (143.2 KB)
Unsaturated Side Chain â-11-Hydroxyhexahydrocannabinol Analogs
Unsaturated Side Chain â-11-Hydroxyhexahydrocannabinol Analogs.pdf (178.1 KB)
Conformational Studies on a Diastereoisomeric Pair of Tricyclic Nonclassical Cannabinoids by NMR Spectroscopy and Computer Molecular Modeling
Conformational Studies on a Diastereoisomeric Pair of Tricyclic Nonclassical Cannabinoids by NMR Spectroscopy and Computer Molecular Modeling.pdf (408.1 KB)
Pharmacophoric Requirements for Cannabinoid Side Chains: Multiple Bond and C1¢-Substituted ¢8-Tetrahydrocannabinols
Pharmacophoric Requirements for Cannabinoid Side Chains Multiple Bond and C1-Substituted delta 8-Tetrahydrocannabinols.pdf (131.0 KB)
New Approaches to Antiglaucoma Therapy
"Cannabinoid Reference: Cannabinoid (CB) receptor ligands like WIN 55,512-2
and CP 55,940 reduce rabbit and monkey IOP when
given topically, showing enantiomeric selectivity.171,172
WIN 55,512-2 decreased aqueous humor production in
rabbits but had no effect on outflow in rabbits or
monkeys.173
New Approaches to Antiglaucoma Therapy.pdf (406.8 KB)
Synthesis and Pharmacological Evaluation of Amino, Azido, and Nitrogen Mustard Analogues of 10-Substituted Cannabidiol and 11- or 12-Substituted A8-Tetrahydrocannabinol
Synthesis and Pharmacological Evaluation of Amino, Azido, and Nitrogen Mustard Analogues of 10-Substituted Cannabidiol and 11- or 12-Substituted A8-Tetrahydrocannabinol.pdf (218.6 KB)
Cannabinoids. Structure-Activity Studies Related to 1,2-Dimethylheptyl Derivatives
Cannabinoids. Structure-Activity Studies Related to 1,2-Dimethylheptyl Derivatives.pdf (247.1 KB)
Potent Anandamide Analogs: The Effect of Changing the Length and Branching of the End Pentyl Chain
Potent Anandamide Analogs The Effect of Changing the Length and Branching of the End Pentyl Chain.pdf (199.5 KB)
Synthesis and Pharmacological Properties of ll-Hydroxy-3-(l’,l’-dimethylheptyl)hexahydrocannabinol: A High-Affinity Cannabinoid Agonist
Synthesis and Pharmacological Properties of ll-Hydroxy-3-(l’,l’-dimethylheptyl)hexahydrocannabinol A High-Affinity Cannabinoid Agonist.pdf (114.4 KB)
Activity of Novel Aminocannabinoids in Baboons
pass that boon a bong please
Activity of Novel Aminocannabinoids in Baboons.pdf (128.3 KB)
Cannabimimetic Activity of Novel Enantiomeric, Benzofuran Cannabinoids
Cannabimimetic Activity of Novel Enantiomeric, Benzofuran Cannabinoids.pdf (959.7 KB)
Some 9-Hydroxycannabinoid-like Compounds. Synthesis and Evaluation of Analgesic and Behavioral Properties
Some 9-Hydroxycannabinoid-like Compounds. Synthesis and Evaluation of Analgesic and Behavioral Properties.pdf (95.0 KB)
Two New Unsaturated Fatty Acid Ethanolamides in Brain That Bind to the Cannabinoid Receptor
Two New Unsaturated Fatty Acid Ethanolamides in Brain That Bind to the Cannabinoid Receptor.pdf (121.1 KB)
Stereochemical Requirements for Cannabinoid Activity
Stereochemical Requirements for Cannabinoid Activity.pdf (156.7 KB)
Potent Cyano and Carboxamido Side-Chain Analogues of 1’,1’-Dimethyl-delta 8-Tetrahydrocannabinol
Potent Cyano and Carboxamido Side-Chain Analogues of 1’,1’-Dimethyl-delta 8-Tetrahydrocannabinol.pdf (126.5 KB)
A Half Century in Medicinal Chemistry with Major Emphasis on Pain-Relieving Drugs and Their Antagonists
“Cannabinoid Reference: They developed a large series of bicyclic cannabinoids
(with retention of the alicyclic hydroxyl substituent)
far more potent as analgesics than morphine.”
A Half Century in Medicinal Chemistry with Major Emphasis on Pain-Relieving Drugs and Their Antagonists.pdf (226.8 KB)
Synthesis of a Norcannabinoid
Synthesis of a Norcannabinoid part 1.pdf (112.7 KB)
Synthesis of a Norcannabinoid part 2.pdf (107.2 KB)
Benzoxocin and Benzoxonin Derivatives. Novel Groups of Terpenophenols with Central Nervous System Activity
“Cannabinoid Reference: Very few central nervous system (CNS) agents are
known which do not possess a nitrogen atom. The most
conspicuous ones among them are the active cannabinoids,
1 both natural and synthetic. The structure-activity
relationship in this series has been investigated in some
detail2,3 and it has been suggested2 that a tricyclic ring
system containing a benzopyran moiety is a requirement
for CNS activity.”
THC is a Terpenophenol
Benzoxocin and Benzoxonin Derivatives. Novel Groups of Terpenophenols with Central Nervous System Activity.pdf (228.8 KB)
9-Nor-A8-tetrahydrocannabinol, a Cannabinoid of Metabolic Interest
9-Nor-A8-tetrahydrocannabinol, a Cannabinoid of Metabolic Interest.pdf (108.6 KB)
Hashish.1 Importance of the Phenolic Hydroxyl Group in Tetrahydrocannabinols
Hashish.1 Importance of the Phenolic Hydroxyl Group in Tetrahydrocannabinols.pdf (100.4 KB)
Analgesic Properties of the Tetrahydrocannabinols, Their Metabolites, and Analogs
Analgesic Properties of the Tetrahydrocannabinols, Their Metabolites, and Analogs.pdf (153.5 KB)
Benzoxocin and Benzoxonin Derivatives. Novel Groups of Terpenophenols with Central Nervous System Activity. A Correction
Benzoxocin and Benzoxonin Derivatives. Novel Groups of Terpenophenols with Central Nervous System Activity. A Correction.pdf (62.6 KB)
Hashish.1 Unsaturated Side-Chain Analogues of A8-Tetrahydrocannabinol with Potent Biological Activity
Hashish.1 Unsaturated Side-Chain Analogues of A8-Tetrahydrocannabinol with Potent Biological Activity.pdf (98.3 KB)
Drugs Derived from Cannabinoids. 1. Nitrogen Analogs, Benzopyranopyridines and Benzopyranopyrroles
Drugs Derived from Cannabinoids. 1. Nitrogen Analogs, Benzopyranopyridines and Benzopyranopyrroles.pdf (251.2 KB)
Drugs Derived from Cannabinoids Basic Esters of Nitrogen and Carbocyclic Analogs
Drugs Derived from Cannabinoids Basic Esters of Nitrogen and Carbocyclic Analogs.pdf (222.4 KB)
Drugs Derived from Cannabinoids. 5. delta 6 delta 10-Tetrahydrocannabinol and Heterocyclic Analogs Containing Aromatic Side Chains
Drugs Derived from Cannabinoids. 5. A6al0a-Tetrahydrocannabinol and Heterocyclic Analogs Containing Aromatic Side Chains.pdf (294.9 KB)
Drugs Derived from Cannabinoids. and Thienobenzopyrans Sulfur Analogs, Thiopyranobenzopyrans
Drugs Derived from Cannabinoids. and Thienobenzopyrans Sulfur Analogs, Thiopyranobenzopyrans.pdf (103.6 KB)
Drugs Derived from Cannabinoids. Effect of Alkyl Substitution in Sulfur and Carbocyclic Analogs
Drugs Derived from Cannabinoids. Effect of Alkyl Substitution in Sulfur and Carbocyclic Analogs.pdf (99.0 KB)
(-)-3-Isothujone, a Small Nonnitrogenous Molecule with Antinociceptive Activity in Mice
“Cannabinoid Reference” The results are compared with those of several cannabinoids
we have tested previously5 and morphine and codeine."
(-)-3-Isothujone, a Small Nonnitrogenous Molecule with Antinociceptive Activity in Mice.pdf (131.4 KB)
9-Nor-9-hydroxyhexahydrocannabinols. Synthesis, Some Behavioral and Analgesic Properties, and Comparison with the Tetrahydrocannabinols
9-Nor-9-hydroxyhexahydrocannabinols. Synthesis, Some Behavioral and Analgesic Properties, and Comparison with the Tetrahydrocannabinols.pdf (95.9 KB)
Cannabinoids. 1. 1-Amino- and l-Mercapto-7,8,9,10-tetrahydro-6H-dibenzo[6,d]pyrans
Cannabinoids. 1. 1-Amino- and l-Mercapto-7,8,9,10-tetrahydro-6H-dibenzo[6,d]pyrans.pdf (180.0 KB)
Cannabinoids. 2. Synthesis and Central Nervous System Activities of Some B-Ring Homocannabinoid Derivatives and Related Lactones
Cannabinoids. 2. Synthesis and Central Nervous System Activities of Some B-Ring Homocannabinoid Derivatives and Related Lactones.pdf (172.1 KB)
Cannabinoids. Synthesis and Central Nervous System Activity of 8-Substituted 10-Hydroxy-5,5-dimethyl-5ff-[ 1 ]benzopyrano[4,3-c]pyridine and Derivatives
Cannabinoids. Synthesis and Central Nervous System Activity of 8-Substituted 10-Hydroxy-5,5-dimethyl-5ff-[ 1 ]benzopyrano[4,3-c]pyridine and Derivatives.pdf (147.2 KB)
Drugs Derived from Cannabinoids. 7.1 Tachycardia and Analgesia Structure-Activity Relationships in delta 9 Tetrahydrocannabinol and Some Synthetic Analogues
Drugs Derived from Cannabinoids. 7.1 Tachycardia and Analgesia Structure-Activity Relationships in delta 9 Tetrahydrocannabinol and Some Synthetic Analogues.pdf (91.6 KB)
Some 11-Substituted Tetrahydrocannabinols. Synthesis and Comparison with the Potent Cannabinoid Metabolites 11-Hydroxytetrahydrocannabinols
Some 11-Substituted Tetrahydrocannabinols. Synthesis and Comparison with the Potent Cannabinoid Metabolites 11-Hydroxytetrahydrocannabinols.pdf (128.8 KB)
3’Hydroxy- and (±)-3’,ll-Dihydroxy-A9-tetrahydrocannabinol: Biologically Active Metabolites of A^Tetrahydrocannabinol1
3’Hydroxy- and (±)-3’,ll-Dihydroxy-A9-tetrahydrocannabinol Biologically Active Metabolites of A^Tetrahydrocannabinol1.pdf (165.5 KB)
New Antihypertensive Cannabinoids
New Antihypertensive Cannabinoids.pdf (133.1 KB)
New Azacannabinoids Highly Active in the Central Nervous System
New Azacannabinoids Highly Active in the Central Nervous System.pdf (104.2 KB)
A Cannabinoid Derived Prototypical Analgesic
A Cannabinoid Derived Prototypical Analgesic.pdf (183.5 KB)
Synthesis and Pharmacological Activity of Some 9-Substituted A8-Tetrahydrocannabinol Analogues
Synthesis and Pharmacological Activity of Some 9-Substituted A8-Tetrahydrocannabinol Analogues.pdf (101.7 KB)
Hashish: Synthesis and Central Nervous System Activity of Some Novel Analogues of Cannabidiol and Oxepin Derivatives of A9-Tetrahydrocannabinol
Hashish 1 Synthesis and Central Nervous System Activity of Some Novel Analogues of Cannabidiol and Oxepin Derivatives of A9-Tetrahydrocannabinol.pdf (152.0 KB)
me trying to read all the data hurts
I’m trying to make a space for people to just mess around with stuff and see what comes up