Have you tried micro dosing with mushrooms?
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have you tried microdosing with heavenly blue morning glory? Cheaper than shrooms and legal
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I have not. I will read into it.
I haven’t found much to read on it when i looked beyond reddit posts. I have only my personal experience thats why i was asking
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I did a quick search and only found a few experiences on reddit (some good, some bad).
What is your dosing like?
literally one to two seeds
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In the negative experience I read about the guy took 11. Lol. Makes sense now.
Yeah i feel that might be enough to cause nasea or if you are light a bit more head change than was desired. Not tripping, but enough to feel uncomfortable
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Kitty helps with pain and nasal spray is a nice way to go. S+preferred, SWIM had a k mix of salene, cpl drops VG and 1 drop of sage oil. Klus k boosts opioid sensitivity so he took with kratom. No more pain from what i hear. lol
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So everyone here is aware of cannabinoid isomerization. What about isomerizing kratom to 7-OH mitragynine?
Can it really be done with exposing a kratom extract solution to UV or Hcl?
anecdotal evidence says yes. i have nothing empirical to back it up. I have exposed kratom to uv for extended periods and noticed a difference in effects
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We dabble in Kratom, also extracts. Here is a 15% off coupon code for my future people.
Code: FUTURE4200
Yes and quite easy
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@Roguelab What is your catalyst?
Oxigen and UV
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7ohm, the opioid alkaloid has a mu opioid receptor score on par with morphine. Mitragynine, is also an adrenergic receptor agonist, which is how clonidine works to prevent withdrawal. The beautiful thing about kratom is that it has a clear ceiling of effect. In fact, high concentrations of Mitragynine block all opioid activity including heroin and morphine. It does have w/d syndrome, but it is a g protein pathway opioid agonist, vs a beta arrestin pathway. This means that tolerance, and withdrawal are minimal, as are cns depression. It’s safe, effective and self regulating. It is addictive, nonetheless. If you’re addiction free, why not keep it real? If there’s good chance for relapse, then get addicted to something less evil. Best cure for addiction is addiction. It’s a theory anyway. Replacement therapy.
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That’s what AA is, right? Filling the time you would be boozing with a support group?
Anyways, oxidizing kratom is easy. Buddy did an Etoh soak and placed it in a sunny windowsill and forgot about it. Filter and evap and it was definitely more narcotic, no energetic effects to speak of. The dosage was subjectively half of what he normally took.
*oxidizing, not isomerizing. Thanks for the clarification @roiplek.
It’s an oxidation, not an isomerization. The latter means the molecular composition stays the same, but the atoms are connected differently afterwards.
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The problem is that we can’t tell if it’s the extract or us. Oxidation occurs inside the body from cyp3a4 enzyme, converting the mitragynine into 7ohm. A recent study showed that 7ohm levels were roughly the same in all leaf, across all drying methods. McCurdy also estimated that around 6% was getting converted. Extracts have as much as 4% 7ohm. The problem is that high concentrations block opioid activity. This might be why extracts don’t have opioid effect for some. They’re simply taking too much. So, there’s this threshold it appears. We all take the same amount and attribute the effects to genetics as if it were cannabis, but all that seems to matter is the dosage. The only difference in leaf, that I could find was the level of Mitragynine. There is no corresponding increase in 7ohm for heavily oxidized leaf like we used to think. All of the effects are explainable by varying this one alkaloid. What’s interesting is that in Asia, where they take it for stim properties, they take large doses. The prevalence of addiction is much lower because 7ohm is addicting while mitragynine is not. The more you take the less opioid and more stim it will be.