Interesting… I don’t normally get constipated from it, and I assumed the irregular irregularity was just due to all the damn fiber I’ve been eating from kratom powder!
I am on a pretty consistent high dose for pain, and there has been no development of tolerance to the pain relieving qualities, which is completely awesome in my book!
My fibromyalgia responds well to about 7-12g taken 3 times per day. The pain, depression, and anxiety all vary, though, so sometimes that dose is taken up to 5 times in a day.
Whatever the colors actually mean…
That is to say, I’ve heard from all levels of source credibility, everything from leaf color from different climate conditions (it’s basically an evergreen, so not seasons), to just plain fresh leaf color (harder to believe), to leaf vein color, to drying or actual fermentation treatments of the leaves to obtain the different colors…
So, fwiw, the greens and whites seem to be best for daytime, and red/brown (or purple?) seems best for nighttime, in general, but I find it difficult to get decent pain relief from most red/brown types. Finding an effectively pain-relieving source of nighttime kratom for me has been a quest fraught with trial and error.
Some also claim that the age of the trees makes a difference, and therefore older stands from different islands are more prized than younger stands, but who knows what one actually gets… kinda like pot “strains”, especially when buying concentrates, ya know?
I have found that lower doses are better for sleepy time, and higher doses are better for waking times… but this is opposite the “common” understanding of the dose/activity relationship, apparently. I guess for most folks, it’s the other way around.
A bit of experience with the water based extract from Indonesia (although legally that is not supposed to be exported for some reason). It is quite strongly stoning, and far more easy to “overdose”… for me, resulting in very loudly snoring sleep, according to my girlfriend who of course was made aware of the situation to keep watch! Keep in mind my usual dose is 7 to 12 times the recommended daily amount per dose (I have had a very “hard head” to kratom, from the very get-go.), so be VERY careful with ANY extracts of kratom!
A word of WARNING
One day, in the time I was still stepping off of Tramadol, after taking a normal kratom dose in the morning, I forgot my noon dose, so just waited until about 3 or 4pm and took my old dose of Tramadol. I had done this on prior days with no real ill effects, but that particular day, I apparently had a series of full-on convulsive catatonic seizures!
Scary to say the least, so a week or two after that, when I had my brain back, I dove into research and started asking some very hard questions. Come to find out that kratom may have an inhibitory effect on the liver enzymes responsible for metabolizing Tramadol. It’s not confirmed, exactly, but it is the most likely culprit I could find for the onset of seizure.
If you don’t already know, Tramadol is known to lower the seizure threshold in some patients on its own… and although I had never experienced anything like that in over 5 years taking Tramadol, it happened within just a week of having been taking kratom (morning) and Tramadol (evening)! The adverse affect was apparently cumulative!
So please DO NOT MIX kratom with any opioids or other meds that have α2 and opioid combined receptor activities!
All that said, I have metabolic mutations that affect my body’s processing and therefore efficacy and danger of many types of drugs. Namely MTHFR, TT allele.
Also, with high functioning autism spectrum disorder, my brain is wired differently than those of “neurotypical” folks.
As always, ymmv!