Looking for existing businesses that use MIT & 7-HydroxyMitragynine in their manufacturing process.
We are currently building out a state of the art extraction lab, to sustainably produce hundreds of Kilos monthly. We also work with a plethora of existing partners that have been producing smaller quantities of extracts & conversions currently.
We are just trying to Guage the market conditions as the regulations continue to fluctuate in various markets on various products… Before we pull the trigger on a vertically integrated Kratom Extraction business, we wanted to shout out to folks who have been thriving in the kratom economy, and want to see what demand exists for consistency and reliability on high quality extract product’s.
Definitely want to chat with you regarding inputs, might be on to something big here with a new form of limonene that is tailor made for MIT extraction. Half the cost of Food Grade D-Limonene and 40-50% faster maceration times. Gallon of FG Limo goes for over $40 per in bulk quantities.
I would like someone to explain the “salt” or “freebase” MIT, because I dont think the “salt” form is actually a salt. Also, it makes no sense to me that “freebase” is less pure than a salt, since typically the opposite is true. I think its more of a slang term for it’s method of production? Someone explained it to me once but it still made no sense why the purities differed.
Most common is acetate salt. I don’t think there’s any correlation between salt or freebase and purity. I think the salt is somewhat more stable though.
I mean I don’t want to sound dumber than I already am but you are correct on the differentiation in extraction methods. Salt base is typically extracted using limonene, acids, and water, and free base is typically extracted using methanol, dichloromethane/methylene chloride, and acids.
Salt base is the protonated form of the alkaloid. It’s usually precipitated or crystallized out of a low ph water solution. Free base is the deprotonated form, less water soluble, usually partitioned into an organic solvent like DCM or ethyl acetate and then dried in a rotovap. Different extraction methods, but the crystallization of the salt base usually leads to higher purity mit but less of a full spectrum extract, but all that just depends on methods.
The market is in a bit of a transitional phase right now with everything going on with 7oh. Florida was a big market that was removed basically over night. Lots of uncertainty with potential federal scheduling. Currently there is a decent demand for MGM-15 if you have the wherewithal to convert it.
How do precipitate an alkaloid out of a low pH water solution? Typically you precipitate out an alkaloid freebase from an acidic water solution by raising the pH.
I should add that I have never extracted the stuff so I don’t know what people are doing. I believe the “salt” method might be something like limonene extract, then low pH water liquid/liquid extract the limonene, and then boil off water and done. I still dont think its actually a “salt” in its molecular form though.
Yes, salt based is usually through the limonene method. The mit is extracted into the limonene with the help of a base to keep the alkaloids lipophilic. Then the limonene is sprayed with GAA solution to convert the mit to the protonated salt base form. How you can crystallize it from there varies. You can use ultrasonicators, heat, or other methods. Honestly there are patents available online you can read about it.
I think the question then remains, if a salt is the protonated form of the alkaloid, which is what causes it to be polar/water soluble, how are their acetate salts? Would not the alkaloid exist simply in it’s protonated salt form? The protonation most likely occurs on the nitrogen in the pyrrolizidine where it has the electron sphere that can accept the proton. How does the acetate come along with it? It wouldn’t, so it’s either salt base or free base form. There are no acetate salts or oxalate salts.
Also you can use limonene to make a free base powder. In fact, in the limonene phase the alkaloid would exist in its free base form, that’s how it is soluble in the d-limonene.
Methanol is so much cheaper, I have a hard time seeing the COGS play out well even paying $40 a gallon for Limonene.
Yes, happy to catch up with you Luke, we are leaning more towards Methanol, for all intents and purposes it seems like a more affordable way to extract at scale. Especially with the Limonene shortage, [seemingly due to some Citrus crop issues.]
Salt is more stable for storage, while Freebase easier for conversion… so if you intend to put it into product, salt is generally preferable. VS if the goal is to convert 7-OH-MIT, then Freebase saves a step.
Methanol is a clean up nightmare especially at scale. We have been working on process development with process chemist and are close to having an efficient, safe and scalable option for getting to the 75-80% potency. It will have a lot less unit of operations compared to how everybody is doing it now, which is just throwing a ton of solvent at the problem. Reach out if you would like to chat about it!
The team has a fairly broad purview of Lab Construction, [one member who brings $4mln worth of equipment to the party] built an 87,000ft² Lab that sold for $5mln.
Another member currently optimizes efficiency for fortune 50 corps like McKesson, and Amazon, FedEx etc… tweaking conveyer belts and robot arms to perfect existing systems… but his heart is in intoxicants… and he truly wants to optimize and inherently automate as many aspects of our business as possible.
The 3rd member is working in the medical lab space and bored, he truly wants to be perfecting SOPs, playing in a practical setting, drawing from the scientific literature, while perfecting our processes.
In a perfect world, if the 7 position is the premier location teased by the oxidizing agent… supposedly the reaction can hit efficiencies in excess of 75%…
Obviously if you can convert >50% more efficiently then others, your business is going to thrive.
All we want to do, is produce the highest quality product, with the lowest cost. We want to automate as many aspects as possible, and streamline efficiencies. We wish to produce as much as possible, and sell it to as few entities as required to establish a long term Most Favorable Nation, supply contract agreements.
Then we’d like to play around with Nuutropics, and Formulations that draw on like modalities and therapeutic effects stacked for Entourage.