I cannot think of any other examples.
In my opinion, the blame lies squarely with the USDA and the poorly written Farm Bill. The fact that a lot of purposeful misinterpretation followed isn’t that surprising.
The “industry” as a whole is incredibly shortsighted. There will be a blowback just like what happened when the DEA targeted synthetic cannabimimetics (Spice, K2) about a decade ago.
oxycodone from thebaine might be a good example, although artisinal poppy cultivation never had the penetration hemp does
Don’t give them the idea…
Some thirty years ago one of my teachers was enlisted as an expert witness for the prosecution in a case which I believe involved exactly what you suggest. A clandestine lab had been uncovered and thebaine had been found along with a lot of boron tribromide, a reagent with narrow uses, demethylation of methyl aryl ethers chief among them.
animal trials are easy to get clearance for, it’s humans that you have to have ethics panels drill you for a year before they make a decision.
I was working on live cell analysis that would help skip a lot of animal trials. Liver drug? test it first on hepatocytes. etc. We measured metabolism of the cells in real time as a function of exposure to toxins. I jumped off the merry-go-round when they used them for chemical/bioweapons detectors.
This is why I have such respect for you. Out there protecting the little guys and the small guys. While the rest of the industry is milking them till their dry and bankrupt, hundreds of farms going under that most of them have been generational farms and they went under cause of hemp or because of extraction labs fcking them.
Admit when your wrong, do as much as you can to fix it, and be straightforward with everyone you deal with and you’ll be a successful company. [quote=“Future, post:170, topic:106756, full:true”]
I canned Beaker and Wrench from the GLG for exactly this.
After fucking up a multiple $100k order with @Siosis multiple times, they agreed to make it right only if he and I would sign a Non Disparagement Agreement.
They didn’t want me telling other people to avoid doing business with them because they are liable to put a couple hundred thousand worth of equipment in a $50 crate.
Needless to say I told them to kick rocks.
A non disclosure agreement with a customer whom you give privileged details about mfg processes and such, is one thing.
Blackmailing them into signing a non disparagement agreement a whole different thing
[/quote]
States that bio availability of oral thc is 10-20% as most of it gets wrecked by first pass metabolism
“Several factors may account for the low oral bioavailability of 4−20% (as compared to intravenous drug administration), including variable absorption, degradation of drug in the stomach, and significant first-pass metabolism to active 11-OH-THC and inactive metabolites in the liver.”
“The prodrug strategy can improve bioavailability after absorption turning the otherwise negative effects of first-pass metabolism into an advantage (Fig. 2).”
Based on these studies there is vast room for bioavailability improvement in oral thc
These are real life testimonials from clients of mine, are you saying these effects are in our head? Because I report a longer duration when d9 thc o is consumed also, the first night I smoked it when I made it last month I slept all the way threw the night. This isnt BS which is why I’ve been telling you to try it instead of sit here and derail my sales thread
Can you guys cut all the BS talk out from post 109 on into its own thread?
If not I can change the title of this thread as its a sales thread for gummies, not an acetylation bio available thread
Edited because I need to say:
Please!!!
Anecdotal results are anecdotal. The placebo effect exists.
I’d love to see blood plasma levels proving the acetate makes it to the bloodstream or even higher levels of THC than normal edibles.
Otherwise I reserve the right to be skeptical.
Due to the kinetics of the metabolism of the prodrug, there may be a subtle effect on Cmax, but as far as Area Under Curve is concerned, I cannot see why there should be much or even any difference.
The concepts in italics above are cornerstones of pharmacology.
Please keep the acetate talk out of my sales thread
Not really
Placebo isn’t going to happen on thc o when you smoke thc everyday
I already posted above showing that eatables are only 4-12% bio availability, that alone should show you that there room for vast improvements in bio availability
Buy you can keep thinking that, you’re in denial
Real life reports top your opinion anyway
Now go somewhere else to argue about acetate
@trust_level_4 can you please move these to the new thread since these 2 can’t seem to understand about keeping it on topic in a sale thread
When a sale thread keeps regurgitation misleading marketing claims while showing disregard for how things work you better believe that I will try to set things straight.
The point we are trying to make is that acetylation of THC might very well lower oral bioavailability, not that we expect you to understand that position.
Except my marketing claims aren’t misleading
You literally have no science to back anything up you say, it’s literally based on your knowledge which seems to be slipping to me as you didn’t even know the bio availability of oral thc is 4-12% max and you’re in MY thread arguing with me when I’ve shown more scientific proof then you
Why the fuck would it do that when it’s already so LOW?
I have no reason to believe anything you say as nothing you say even comes close what the paper report
Increasing water solubility would actually allow better absorption in the gut, it’s in the papers I posted but God forbid you read anything I post instead of being the typical PhD who thinks he knows everything
There’s multiple factors that contribute to oral thcs low bioavailability including first pass metabolism which a pro drug would help with
This was literally your reply to my 10 paragraph post, you didn’t comment on first pass metabolism, bioavailability, nothing I commented on
All this coming from a dude who claims to know what a drug does but hadn’t even tried it
Stay out of my threads or I’ll make a post about how bad your consulting services are and how much of a disrespectful twat you are to someone who’s paid you 1000s of dollars
Screenshots incoming.
I mean who would really enjoy paying someone 1000s of dollar in consulting fees just to have them derail a sales thread that literally has nothing to do with them.
There’s alot more to this then meets the eye, and I’ve never been a fake fuck like half you guys on here who act cool to someone face and talk shit behind there back
I’ll gladly roast the fuck out of a fake
Funny it took me making threats about making a post on his consulting services to get him to take it to my DMs instead of in this thread (which is a year old and is now trashed because of all the side talk)
He cried about me posting on his IG about D8 being legal, yet he’s doing the same shit he cried about
It’s alright, this thread is getting turned into a mitokid thread so it acts as an example of how he treats his consultsees
That’s because the professional thing to do is to handle it in the DM’s instead of airing out your dirty laundry to the forum in an effort to throw salt on his name.
You’re just having a fit because he corrected you. If I had to guess, you perceived him as being disrespectful to you because you were too stupid to understand something he was trying to teach you and you felt bullied.
Maybe if he’d have had the same consideration with his opinions I would have, he hasn’t corrected me on anything though everything he’s posted is literally his opinion, he hasn’t even posted any relevant data like I have which is why he shouldn’t be in my sales thread posting his opinions
That’s why on my IG he even admitted he thought inhalation absorption from smoking would be higher then what the papers I posted reported (which he hadn’t even read)
It’s funny because he posts shit like this which just proves my point as the LogP of thc is 7.26
doesn’t even include the acetate as a comparison. By and large, the acetate is an unstudied compound and the fact unsubstantiated claims are made with respect to its properties on this Forum is dangerous. There is a very clear risk of imbibing too much when it’s vaped. When I explained that to you in one of our one-on-one meetings you clearly hadn’t considered that, you’re basically only chasing new molecules without pondering consequences.
As for your edibles, that risk is obviously much lower, since your average consumer already expects delay in onset.
And one of the rules says that the logP must not be >5 for whatever that is worth to you. Acetylation of the phenolic hydroxyl only serve to increase logP.
Listen, I have no problem teaching anyone any kind of chemistry. I just hate all this weird dissecting of what I said when. I clearly didn’t take into account the extensive pyrolysis that occurs during smoking, and I pointed out to you that correcting for pyrolysis, the uptake by smoking is more like 60%.
The fact that you clearly pointed out that I was the one who helped you with the acetylation reaction, without my permission I must add, then turn around and express disappointment in my services, that is a little disconcerting.
I have clearly expressed my discontent over your over-sharing of privileged information not only originating with me, but with that of others.
You have no idea how many times I’ve had to defend you, you of anyone know how I instantly answer any and all of your chemistry questions.
I have visited your facility at four occasions, driving six hours for a 4-5 hour meeting. You have had nothing but praise for what I help you with.
In my DM to you, which I am sure the admins can read, I did apologize for stirring things up but sometimes one is hardest on the ones one care most about.
And now I publicly apologize. I can only hope that you will accept it.
Ahhh and here’s where you’re wrong and I can prove it based on computational log P software
Computation log P of normal THC based on the software says the log p of thc is 7.29 (the paper above reported 7.26)
Here’s thc acetates log P
7.02
Which means it is more hydrophilic
You are fucking wrong jackass which you’re too arrogant to see
And I quote
"
Will have low aqueous solubility, compromising bioavailability. If an adequate concentration of a
drug cannot be reached or maintained, even the most potent in-vitro substance cannot be an
effective drug"
Looks like that’s exactly what the paper said AND I said
And I quote again
“May be sequestered by fatty tissue and therefore difficult to excrete; in turn leading to
accumulation that will impact the systemic toxicity of the substance”
Hmmmmm pretty sure I said this on my IG
Which would also explain longer duration as the acetate can’t be pushed into the fat cells causing lower absortion and bio availability
But yea im done arguing about this because I really did just prove you wrong, so stay the fuck away from me and any of my threads 
@Kingofthekush420 between posts.
Yea, he’s the arrogant jackass here.
