That’s fine to disagree, I have confidence in what I’ve performed in lab and process design/economic evaluation. Sure, we all know the solubility axiom “colder solvent extracts less.” I cant disagree with that since that’s just the nature of solubility. Maybe the scenario youre envisioning is different from those I’ve seen or even OPs, or maybe I didnt explain my justifications clearly enough.
The scenario as stated is this: OP is intending to perform cold solvent extraction and use wiped film distillation, which is a rather robust distillation process that doesnt usually yield a product much above 90-95% regardless (on a good day for most). I mention the robustness of these pieces of equipment with the intention of illustrating that a properly optimized WFE system can tolerate small amounts of some of those unwanted components. One’s goal should not be perfection in removing those components to 0.000000 wt%, but rather to reduce the concentrations of those components to the threshold at which downstream processes are robust enough to tolerate, all the while as quickly/inexpensively with as high of a throughput as possible.
So, OPs questions are “can I get away with a temperature above -80 C” and “do I need to perform these additional purification steps/will they work?” To the first I say, you probably can find extraction/distillation process parameters to avoid going that cold and still produce distilled product within your quality parameters. You should analyze your WFE systems to determine their tolerance for lipids/chlorophyll AND determine what is the maximum temperature extraction that will produce crude that your WFE can remediate. Perform experiments to determine what temperatures extract what undesirables and to what degree. To the second I say, before adding even a single unit operation perform a true cost/benefit analysis. In doing so I would consider the following: The cost difference in equipment/electricity/time to cool large quantities of solvent to -20 C, -40 C, and -80 C. Next, consider the time/labor/raw material/equipment/energy costs/opportunity cost of performing those additional scrubs and filtrations (thus producing bottlenecks and reducing throughput). Consider if the raw materials necessary to meet your demand AND perform those extra steps will put you over your facility’s solvent/general storage thresholds. All of those costs must be offset by how must “better” your final distillate may be, which you also should determine.
Long story short, I’m very doubtful of the process as described (-80C extraction + further downstream scrubs/filtrations). A few weeks’ experimentation and time spend doing a true economic evaluation as well as a cost/benefit analysis are the least that OP should do before saying “yeah I’ll spring for the equipment to reach -80 C, as well as reduce my bottom line further by performing additional potentially unnecessary unit operations.” I’m sure OP and his investors would not be amused to learn after significant investment that they’re going to generate 10% less profits per quarter to raise their potency 0.5%.