There is extensive research in the field of terpene/aroma compounds regarding their effects, it’s just outside of canna, and how it applies through the ingestion methods in canna is certainly “grey”.
But overall, the specific effects, and the conjunction of cannabinoid effects along with them is getting into hearsay, but there’s still significant understanding regarding this.
(Also why I believe the leaning toward heavy gassy in the industry is well, kind of dumb, and pigeonholed)
This is also why chemistry is great in canna, it’s the physical science of the product, but getting into pharmacology, and understanding anatomy and physiology is just as important.
Hemp conversions were an immediate (gofugyoself) for me, as soon as I started hearing about any amount of non-decipherables.
To quote Jeff Goldblum “Your scientists were so preoccupied with whether or not they could, they didn’t stop to think if they should”
You’re absolutely right I remember seeing pictures of Donald Trump in a lab coat mixing chemicals.
Edit: I’m not going to derail this conversation so I’m not going to respond to any more comments about anything deviating from what this is supposed to be about.
In defense of hemp, I wonder if the downfalls that you are seeing are a result of its fairly short breeding history, compared to that of weed, and thus will wane as the years pass and more terpene profiles are bred into it. The other problem with hemp is not the hemp itself, but rather that it is not economically feasible to grow, harvest, dry, cure, and store hemp with terpene preservation in mind.
that t-butyl Cannabinoid posted above…? That is sort of out of
“Left field”, nice spot. what program are you running that
Matches 3D structure with receptor families…?
It’s a free website. You can draw the molecule or copy paste the “smiles” into the text bar to auto populate the molecule.
For example you can go to pubchem and get the identifier for LSD which is CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C
Then put it into the target prediction software and bam.
Bear in mind it seems there are limitations on the software, I found some limits like it is really bad at predictions for chemical weapons and toxic agents like VX and Sarin Gas kinda stuff, so don’t bet your life on anything it says.
Another big reason for why hemp terpenes suffer is you have to keep the crop below 0.3% thc and the field gets tested by the local governing body and you lose your crop if you go over. This really makes it so hemp terp farmers harvest way too early than you would if you didn’t care about thc.
Nice part about cannabis is you can let the plant get nice and ripe. Hemp, you’re always harvesting prematurely before the field gets hot and risky.
When talking about field production, yes. But fwiw it is a lot easier to grow complaint hemp if one is doing it any other way. Greenhouse or indoor flower doesn’t have as much cbd/cbg, but it is also lower in thc, at least in my experience. Once again, whether or not such an idea makes economic sense is a separate issue, which is not the plant’s fault.
Anytime man, glad I could be a part of the convo, and also to take it away from a strictly “chemists” perspective. More to it than just reactions, the physiological elements are crucial.
I added my 2 cents, and will let the big brains do the rest from here.
Here’s the rub with CO2, material prep (always drying and sometimes decarbing) strips terps. It’s send like even though it is great at selective extraction, the prep steps really burn off the goodies.
The workflow gets redundant… (1) Subcritical run - terpene fraction, (2) decarb flower, (3) Supercritical run - cannabinoid fraction. Then (1) gets steam distilled if not viable as-is. What you burn is time.
I was thinking is would be possible to produce a high yield of this novel cannabinoid with a acid catalyzed condensation of 5-tert-butylresocinol with verbenol. I was thinking p-TSA would be an appropriate catalyst for the reaction? In my mind substituting the terpenyl moiety in the reaction could afford various other new tertiary butyl cannabinoids as well.
Master classes in cannabis should include a discussion of testing and extraction efficiencies. Especially how they effect formulations of ratios of compounds. Our lab’s gummy sample prep SOP has a higher efficiency for CBD than THC, so I have to take that into account when formulating the initial distilate ratio mixture to make sure that the end testing result of the gummies is spot on.
