Dissolve 1g of CBD in 10ml 0.005molar H2SO4 in glacial acetic acid.
I initially thought I can create the acid solution by adding 0.5 ml of 0.1 molar H2SO4 to 9.5 ml of glacial acetic acid.
Since a lot of other SOPs underline the importance of anhydrous acids, I was wondering if my solution mentioned above would work since my H2SO4 is only 0.1 molar so a bit of water would act as an ampholyte.
I am new to this and would appreciate every little help
Thanks for your attention.
Not really the most Thc favorable acids for the task
If you insist on h2so4 I would add some NACL
Making hcl in the process an acid of wich we know give s decent results
From my limited understanding, it seems possible that chloroacetic acid can be formed in this way, a very poisonous and carcinogenic chemical and alkylating agent.
So a column chromatography might be necessary to clean the reaction, if one attempts to isomerize with HCl in acetic acid.
Also, does someone know the answer to the question, if only 10% sulfuric acid available, then how much does it matter to have a little bit of water in the reaction?
Could one just add drying agent like sodium sulfate after mixing the two acids?
If i get it right… @Roguelab , if we do AlCL3 reaction with DCM (and everything is dry, and alcl3 is anhydrous). That would slow or stop the reaction, right?
I remember somewhere someone said that “if there’s absolutely no water - the reaction won’t start at all”.
For which reagents \ reactions this rule apply?
(too dry \ anhydrous - bad reaction)
I am not sure, this is a true. In the study yielding the most robust results—specifically regarding AlCl3—super-dry DCM was consistently used. Other studies indicate that the addition of 4A molecular sieves during the reaction favored the D9 isomer; generally, water and the HCl generated during the reaction had a negative impact on the yield of D9 and favored D8 instead.
I know, but this is General Material and Methods for all researches in this material not only for Bf, for all Lewis acids catalizarors where dcm was a solvent. In each researches have been used extra dry dcm. CBDwas not dried but DCB extra dry.
The best result David and I ever got was 15% aqueous solution of phosphoric acid and it was like 97% converted. Something unbelievable. Never were able to replicate.
