I want to do a simple isomerization of CBD to THC.
The SOP has been mentioned a few times on this forum already:
Dissolve 1g of CBD in 10ml 0.005molar H2SO4 in glacial acetic acid.
I initially thought I can create the acid solution by adding 0.5 ml of 0.1 molar H2SO4 to 9.5 ml of glacial acetic acid.
Since a lot of other SOPs underline the importance of anhydrous acids, I was wondering if my solution mentioned above would work since my H2SO4 is only 0.1 molar so a bit of water would act as an ampholyte.
I am new to this and would appreciate every little help
Thanks for your attention.
Not really the most Thc favorable acids for the task
If you insist on h2so4 I would add some NACL
Making hcl in the process an acid of wich we know give s decent results
From my limited understanding, it seems possible that chloroacetic acid can be formed in this way, a very poisonous and carcinogenic chemical and alkylating agent.
So a column chromatography might be necessary to clean the reaction, if one attempts to isomerize with HCl in acetic acid.
Also, does someone know the answer to the question, if only 10% sulfuric acid available, then how much does it matter to have a little bit of water in the reaction?
Could one just add drying agent like sodium sulfate after mixing the two acids?
