I work in a medical cannabis lab and recently we have been discussing ways to isomerize either CBD or d9 THC into d8 THC. I’ve seen several processes that claim to yeild this result but before I start dumping H2SO4 into prefectly good oil I wanted to discuss the best approach. I am also working without a hood and under some strict local guidelines so I wanted to discuss alternative solvents in some cases.
Dissolve 1g of CBD in 10ml 0.005molar H2SO4 in glacial acetic acid.
Let solution stand at room temperature.
After 3 hours CBD has been converted into 52% delta-9-THC and 2% delta-8-THC.
After 3 days a mixture of 15% delta-9-THC, 54% delta-8-THC, 10% delta-8-iso-THC and 10% CBD has formed.
Pour into water (100ml or more) and add cautiously with stirring (foaming!) enough sodium bicarbonate (15g should do) to raise the pH above 7. Extract with petrol ether, wash with water, evaporate solvent to get mixture of starting CBD and predominantly delta-9- or delta-8-THC with some other byproducts depending on the reaction time.
Question 1: is the chemistry in this SOP sound?
Question 2: could I substitute heptane for the petrol ether in this SOP?
Question 3: in the “wash with water” step would it be better to use straight up RO water or to use a saturated saline?
I’ve also read and heard from several sources that the use of activated carbon or a strong acid in a short path distillation can also isomerize d9 to d8. I have not come across any SOPs that sound legit, however. Does anyone have thoughts on a direct isomerization from d9 to d8? In particular as part of a short path process?
I appreciate everyone’s input! We have several patients who could really benefit from d8. Your help helps them!