Give this a shot.
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What is this you say?
Itās worth noting, anecdotally, terpenes can modulate the edible experience, and people can be allergic to certain terpenes. These are important factors in my experience with making medicinal oils for peopleā¦
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He is talking about creating a emulsion ā¦ like nano or lipo emulsion so that the product becomes more bio avb. for his daughter. I think we should all come together here and help him. I am going to produce him a nano water soluble liquid with 100mg CBD 100mg THC per 1ml. If anyone here can produce CBD or THC acetate please reach out so we can provide him with some strong medicine.
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Are people allergic to certain terpenes? If so, what are they?
Yes, they are/can be. As far as I know there isnāt any particular ones that are common. My brother is very allergic to pine sap smells, so I assume one of the pinenes is abrasive to him.
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Coconut oil + good oil ā¦ mix until homogenous. Add lecithin granules ā¦ mix until homogenous.
Thereās been studies done now that show CBDA and THCA are thousands of times more bioavailable than their decarboxylated counterparts. Iām going to start making RSO from fresh flowers in hopes it will be better for pain management.
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Welcome to the future @EliteGP! Interesting to hear of increased bioavailability of acidic cannabinoids. I have heard that they are generally more effective as medicine for things like fighting inflammation, pain, or cancer. Perhaps the increased bioavailability is a major factor.
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Regarding bioavailability, I have heard that mct oil will encapsulate the long chain molecule with a medium chain if the finished product goes through a cycle of freezing and heating to about 180f a few times, therefore improving bioavailability. I have no idea for certain if this is true, but I always froze and heated my oil just in case it was.
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can you cite them please.
ā¦dropping the relevant papers in the data dump would be awesome too
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How do I add a link? Iām not able to.
Mix with some cocoa butter and make suppositories. Youāll increase availability by 40%. Nonpsychoactive as well. Best of luck!
I think he is referencing the following:
CBDa has also shown promise in the treatment of nausea via the activation of the serotonin receptor 5-HT(1A). As compared to CBD, CBDa was able to reduce toxin and motion induced vomiting in shrews at 1000x lower dosages (1).
(1) Bolognini, D., Rock, E. M., Cluny, N. L., Cascio, M. G., Limebeer, C. L., Duncan, M., Stott, C. G., Javid, F. A., Parker, L. A., & Pertwee, R. G. (2013).
More recently the study has been replicated, and similar results were found.
Rock, E. M., Sullivan, M. T., Collins, S. A., Goodman, H., Limebeer, C. L., Mechoulam, R., & Parker, L. A. (2020). Evaluation of repeated or acute treatment with cannabidiol (CBD), cannabidiolic acid (CBDA) or CBDA methyl ester (HU-580) on nausea and/or vomiting in rats and shrews. Psychopharmacology , 237 (9), 2621ā2631. Evaluation of repeated or acute treatment with cannabidiol (CBD), cannabidiolic acid (CBDA) or CBDA methyl ester (HU-580) on nausea and/or vomiting in rats and shrews - Psychopharmacology
As far as general bioavailability CBDa and THCa fall more into traditional drug design parameters and there are a few studies that show this, but this does not make it 1000x more bioavailable. For this application specifically, the acids are certainty more potent.
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