Im working on an under the tongue dissolvable that were planning on using to get dose response curves at John Hopkins
Think a 1 mg psilocybin listorene micro dose strip made from extract
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If you need some consulting let me know.
Sounds interesting, but to be honest , I have never understood the microdose concept, 5HT receptor class are all GPCRs. With the basic idea that these system are like a dial turn half way up to begin with. Like THC1-R. I assume you mean, dissolved in listorene and spotted on a strip?
4-oh-DMT is psilocin!
I’ve heard similar things, seems the 4-oh tryptamines are more prone to degradation. Even regular freebase dmt vapes look and smell pretty gnarly after repeated use. I would like to see test results of a 80% smoked DMT cart - i worry there might be harmful compounds formed from degradation.
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No its actually manufactured into the strip
Were making a strip like the listorene ones using a machine in a full gmp facility
These are going to be used to get dose response curve for actual extract since no one’s using extract for their research and everyone’s using synthetics even though extract has been shown to be more therapeutic
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Right you are, just a fuck up on my part thinking about Bufotenine .. Serotomin and the 5OH series… Yes I have eaten plenty of the 4-OH serious….
And I have been rather interested tin Wood lover’s Paralysis…
Do you know of anyone free basing the psilocin?
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People are attempting it, mostly from synthetic psilocin afaik. I’ve heard mixed results.
Wood lover’s paralysis is fascinating / terrifying. I haven’t verified this myself but a local mushroom expert told me that it only seems to occur in wild foraged wood loving psilocybe species, and not in those same species when cultivated, so it could be due to pesticides or some other toxins that are bioaccumulated by the mushroom in the wild. I’ve also seen speculation that aeruginascin is the culprit due to it’s structural similarity to bufotenidine which can cause paralysis.
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I have heard all of that as well. I have also tried to read all the personal reports that one can find on web. Mysterious and rare.
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I know little about this compound , however, a person from Europe who regularly ate the local mushroom containing Aeruginascin , contended it could not be the Aeruginascin, as they frequently ate large doses with no knowledge of any paralysis . Actually it is reported to produce an intense Euphoria. See the little blurb from Wiki on Aeruginascin (with references).
I am looking for some hard data on Butotenidine action of peripheral ACh receptors found at neuromuscular junctions..but data is slim. I have a personal request in to the author of https://www.sciencedirect.com/science/article/abs/pii/S0731708524004151 for full data copy.
It does not gain central access (supposedly) .
“ bufotenidine showed moderate affinity for neuronal α7 nicotinic acetylcholine receptors (nAChRs), with higher selectivity over muscular nAChRs; and 5HT 3 receptors”. Sort of an odd couple …with about 10x affinity alpha7 over nAChRs.
And again, we are talking about 4 and 5 substituted , n- trimethyl ..tryptamine variants . Some rather surprising pharmacological differences.
Regards
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yep, I’m talking about Psilocin. Sorry for typo. I’m unsure if I have synthetic or natural, but it tested very pure. Heated atomization will not work well due to compound degradation. Nebulization will work, but stability in carriers is surprisingly a major challenge. Dissolving the crystals in anything leads to rapid oxidation.
Yes, I spoke to one gentlemen who tried dabbing substantial amounts with mixed success. I believe that heat+o2 quickly destroys the compound and any “High” was due to the large amount being dabbed(not everything experienced thermal decomposition.) I tried it myself orally(reasonable amounts) with good results.
Yes, I sort of remember from years ago..that smoking did not result in much of a Response..thinking or speculating on decomposition of the form in the dried mushroom. Actually , someone needs to do a free base form, say LLE at pH 8-9, to ensure the amine is free base and not a salt. The latter decomposing upon heating. Some sort of “crack-like” preparation should do for an experimental puff.