At what temperatures do various acids cause isomerization?

Specifically looking to understand acetic and lactic acid isomerization temperatures, but am open to whatever info is available on any acid (preferably food grade acids)
Formic acid is another contender

Can you isomerize at room temp if you use a significant quantity of acid? Like a boatload of acid.


I really hope you two have different opinions on this and are willing to argue over it.


Acetic acid will cause isomerization at 50c in hexane, never tried any lower


Threshold for phosphoric is around 40c minimum. Volume hasn’t made much of a difference.


I’m willing to submit samples if someone pays to have them tested

Ptsa starts at - 10 C
Phosforic acid starts at 48 C
Aluminium cloride anhydrous starts at -10C and probably lower never tried
Indium sulfonic at -5 C
Methane sulfonic at 5 C
Triisobutylaluminium at 10 C
Borontriflouride at -8 C
Anhydrous forms start slightly higher temps +3C


Camforsulfonic has some minimal reactivity below 20c, but 35c was worth noting

HCl was around 30c before it was appreciable, but I ran it in quite low amounts.


Yeah hcl in aquatic or alcoholic solution naars 30C but gaseous at 10 C

I think that in general solvents dcm and dmso are the ones where most acids react in fastest


will acid form cannabinoids isomerize?

Off course as long as long as the whole process is kept on low temps (40C )
The A will stay put and the isomerization will proceed as usual some acids work better for
Cannabinoids+a to issomerize
Camforsulfonic works better on accitic cannabinoids than on those without the A
But triisobutylaluminium borontriflouride and aluminiumcloride all work well on the A cannabinoids where rxn can be performed at 0C yust prepare to work with a load of solvent
For at 0C the noids fall out of solution fast so
Dcm 8liter for a kg
Hexane 12 liter per kg
Ethanol 10-14 L per kg
Fast reactions like aluminium cloride can be done on a little less solvent since rxn time is
Less than 8 min


Hmm good intel ty rogue


Is the objective to cyclize CBD while preventing isomerization of d9 to d8?

I think the objective is to isomerize cbd-a or cbg-a to thc -a D9 or D8
While keeping the A in the process
So roomtemp reactions (watch for the exotherm) or colder and Try to use low bp solvents in the rxn and wash


The objective is to avoid isomerization completely.

Im working on a crystallization process


Are there reasons to believe that d8/d9-THCa would co-crystallize?

Well we know thc-a D9 crystelizes
And I had supposedly thc-a D8 crystelize on me but since there are no standards one can t confirm
As for Thc-a D8 some members produce it frequently and can maybe give more in depth

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The acid hardly matters as much as pH

Below ph1 it will happen at 20C about 60C for ph3 and 150C for 6+ <7


Huh ??? That’s a strange assumption
Magnesium sulfate on it s own will make D8 it s basically neutral
Several activated carbons will make D8
Some are neutral 6.8 ph
The main Lewis acids used for isomerizations
Not all have a low ph
And defenatly not every acid will do the trick right

Decarb your supposed d8 THCa and then test for d8. Problem solved :grin:


I notice new accounts pop on to spread disinfo more often by the day.

Someone thinks “their” process might be discovered so they talk up lies.

This open source thing is such a double edges sword.

Especially because newbs seem to be just as well funded if not more well funded than the pros.

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Ennui is a smart feller