Specifically looking to understand acetic and lactic acid isomerization temperatures, but am open to whatever info is available on any acid (preferably food grade acids)
Formic acid is another contender
Can you isomerize at room temp if you use a significant quantity of acid? Like a boatload of acid.
Ptsa starts at - 10 C
Phosforic acid starts at 48 C
Aluminium cloride anhydrous starts at -10C and probably lower never tried
Indium sulfonic at -5 C
Methane sulfonic at 5 C
Triisobutylaluminium at 10 C
Borontriflouride at -8 C
Anhydrous forms start slightly higher temps +3C
Off course as long as long as the whole process is kept on low temps (40C )
The A will stay put and the isomerization will proceed as usual some acids work better for
Cannabinoids+a to issomerize
Camforsulfonic works better on accitic cannabinoids than on those without the A
But triisobutylaluminium borontriflouride and aluminiumcloride all work well on the A cannabinoids where rxn can be performed at 0C yust prepare to work with a load of solvent
For at 0C the noids fall out of solution fast so
Dcm 8liter for a kg
Hexane 12 liter per kg
Ethanol 10-14 L per kg
Fast reactions like aluminium cloride can be done on a little less solvent since rxn time is
Less than 8 min
I think the objective is to isomerize cbd-a or cbg-a to thc -a D9 or D8
While keeping the A in the process
So roomtemp reactions (watch for the exotherm) or colder and Try to use low bp solvents in the rxn and wash
Well we know thc-a D9 crystelizes
And I had supposedly thc-a D8 crystelize on me but since there are no standards one can t confirm
As for Thc-a D8 some members produce it frequently and can maybe give more in depth
Answers
Huh ??? That’s a strange assumption
Magnesium sulfate on it s own will make D8 it s basically neutral
Several activated carbons will make D8
Some are neutral 6.8 ph
The main Lewis acids used for isomerizations
Not all have a low ph
And defenatly not every acid will do the trick right