Flavonoids are good and some processes preserve them better than others. As you note, the addition of the oxygen atoms to their terpene structure increases their polarity and miscibility in polar solvents like water and alcohol.
Rick Simpson Oil has never preserved them but was still effective for the purpose for which he designed it, that didn’t include flavor and bouquet.
What @MimiEmu has developed are ways to improve the RSO process by removing more of the non-targeted elements, as well as residual Isopropyl.
I’ve sampled his RSO orally and by dabbing, so can attest that the smell, taste, and effects are the same as or similar to RSO, with higher potency.
From a toxicity perspective, FDA limits for ethanol and isopropyl in food and drugs are the same. See cut and paste for Class 3 solvents below:
The LD-50 Rat (50% died) for Methanol is 5628 mg/kg, Isopropyl is 5840 mg/kg, and Ethanol is 10,470 mg/kg.
Also of concern is damage to our central nervous system, with Methanol targeting our optic nerves and Isopropyl our auditory nerves.
All three will kill us, or damage our livers and nervous systems at the right dosage, but there is a wide margin between that number and that allowed in food or pharmaceuticals.
Solvents in Class 3 (Table 3) may be regarded as less toxic and of lower risk to human health.
Class 3 includes no solvent known as a human health hazard at levels normally accepted in
pharmaceuticals. However, there are no long-term toxicity or carcinogenicity studies for many
of the solvents in Class 3. Available data indicate that they are less toxic in acute or short-term
studies and negative in genotoxicity studies. It is considered that amounts of these residual
solvents of 50 mg per day or less (corresponding to 5,000 ppm or 0.5 percent under Option 1)
would be acceptable without justification. Higher amounts may also be acceptable provided they
are realistic in relation to manufacturing capability and good manufacturing practice (GMP).
Ran dirty extract and some cleaner extract. Not a lot of gunk in brine or bottom. Some stuff at the solvent brine interface which might have come from lemon juice. Really need to use ascorbic/citric acid powder to be sure.
Chlorophyll didn’t drop out as hoped. Note I said hope and not expected. You can always hope right?
Will let it sit but so far opinion is Meh… now I have salt to clean out of the oil.
Anyway, isn’t the point of RSO making thick sludge? Maybe I should go 80’s on it and boil the buds in IPA for an hour?
Had a thought. Its probably too late for your extraction. I’ll be running video session making oil for the facebook group, via Google Meetings. You don’t have to join the group to join the video sessions. I’ll post times here shortly. Here’s the facebook group if you want to stay up to date -Cannabis Home Sciences | Facebook
This coming Monday at Noon and 5pm PST, I will be running virtual meetings to show how to do a 2oz extraction. This should take no more than an hour, we can hangout and chat afterwards. The sessions will use Google Meet with the meeting instructions posted here a half hour before each session.
MONDAY JAN 9TH 12PM PST
MONDAY JAN 9TH 5PM PST
Check this thread a half hour before showtime for meeting info.
Edit: Corrected the date…
RSO 2.0 is being retired. Refer to the thread “Introducing Refined Cannabis Extract - RxCE”. This new process simplifies degumming, gets rid of salt, and is open to using Ethanol, Isopropyl, Ethyl Acetate or Acetone for the bulk extraction. No questions here please, go to that thread for discussions.