The biggest decision will be whether or not CBD can be used as an active ingredient in dietary and food products,
" In addition, pathways remain available for the FDA to consider whether there are circumstances in which certain cannabis-derived compounds might be permitted in a food or dietary supplement. Although such products are generally prohibited to be introduced in interstate commerce, the FDA has authority to issue a regulation allowing the use of a pharmaceutical ingredient in a food or dietary supplement. We are taking new steps to evaluate whether we should pursue such a process. However, the FDA would only consider doing so if the agency were able to determine that all other requirements in the FD&C Act are met, including those required for food additives or new dietary ingredients."
I interpreted the language they used in the full statement to be that currently CBD is an active ingredient in a FDA approved pharmaceutical, therefor it is not currently allowed as a dietary supplement, even supplements bearing the “Not evaluated by the FDA to be GRAS” statement, but that they are evaluating and have the authority to allow and regulate the use of a “pharmaceutical ingredient” in a standard dietary supplement.
I believe all the larger CBD companies have, and will continue to lobby for the regulation to come into place, and in turn there will most likely be a required license for said production, cutting out illegitimate producers, but not necessarily requiring clinical trials.