So have an option of producing
Enzyme synthesized Psylocibine in numbers but does it make sense ?
I asume it cannot be imported in the USA
It s illegal on this side of the pond
So I would have to move operations
And then would this make sense
Would enzymatic retrieved psylocibine
Be legal in the states like Colorado
7 Likes
Here in CO, it was called the “Natural Medicine Health Act”, as it excludes synthetic. It also specifically states it is still a felony to “Extract natural medicine with inherently dangerous chemicals” (which I guess is defined as <100f flash point).
I don’t have any price numbers because I think the highest potency stuff I’ve heard around is like ~8% psilocybin sugar slabs.
2 Likes
I’ve cajoled these naturally occurring yeast, into making the naturally occurring molecule psilocybin, using naturally occurring enzymes….
Which as it happens is water soluble….although you’re right, dihydrogen monoxide has killed all kinds of horses.
10 Likes
Pure dihydrogen monoxide has a pH of 7. This is higher than any acids known to men. 
10 Likes
I’m pretty sure they added that just to keep specifically DMT extraction illegal, but failed to realize that there are still plenty of other solvent choices out there despite the vague language.
the law is very vague, but state licensing is coming that will allow for fully equipped extraction labs to operate much like cannabis. make sure you dont miss out on the early application period!
1 Like
I do have a cubensis product idea I’m trying to put together but it’s probably going to remain a pet project unless I really get my shit together.
2 Likes
Bump whaat no interest or no pricing available ?
I’ve only seen/handled what I would call “crumble”, a crude extract that was homogenized and purged in a vacuum oven. Beige, coarse powder with a distinctly shroomy “umami” flavor. Potency roughly equivalent to 10x biomass, which is still only probably in the 8-12% range.
Hard to know what the price would be for something so pure. It would be extremely efficient for production of micro-dose products, but does pure psilocybin give the same effect as psilocybin + psilocin + other alkaloids? Like comparing the difference between flower and THCA isolate. You’d probably be able to generate some demand if you could produce samples for folks to try, but there will always be some hesitation to purchase synthetics when it comes the “all natural earth medicine” crowd.
2 Likes
Purely speculative…
$80k/kilo for synthetic
$120k+/kilo for naturally derived
2 Likes
I think 4-aco-dmt retailed around 80/g in smaller quantities, I’d wager lower
1 Like
Generally, research volunteers have been given synthetic.
Also, when Albert Hoffmann visited Maria Sabina, he brought synthetic psilocybin pills, and after a ceremony, she said the pills “really contained the spirit of the mushrooms”.
I have pet theories about minor alkaloids and MAOIs but I really don’t want to call that an entourage effect
5 Likes
What would you call yeast promoted of natural biomass 
Shit the agar and all other compounds are natural
1 Like
Thank you
What’s the price for such crumble ?
Oregon or colorado would be your best options.
4 aco is going for 50k per kg right now.
3 Likes
If you can find it at all. I’ve seen as high as 75-85k
2 Likes
how were the pharmaceutical companies manufacturing psilocybin extract way way back in the day before it was outlawed?
I always assumed they were doing a liquid grow method as in one of Leary’s books, probably the psychedelic experience, so him Metzger and Alpret, they mentioned the mushrooms were mass produced in large vats at the pharmas who were supplying them, the book itself might even go in to more detail than that but that is all I recall and even that memory is suspect, probably not even the right book but I assume they weren’t doing anything of this sort, or is this all old school chemistry bullshit that I pretend to follow and understand?
regardless always fascinated by my favorite lil anti depressant
Oregon is at 10k per kg of extract. I beleive its somehwere between 20-30% getting it higher is economical as your returns keep getting kess and less. Hope this helps.
2 Likes
Gosh this is just wild. I remember doing extractions like, 10yrs+ ago and thinking there’d never really be a market for it, since you can just do honey or things like that which are waaay more shelf stable.
I focused on gourmet production for a legitimate business and now, ten years later, reading this thread has brought back the itch!
Times do be a’ changin’!
2 Likes
Doesn’t honey have water? I’m assuming aged honey and mushrooms would still lead to some degradation through hydrolysis.
I mean, if you’ve eaten honey and mushrooms, it’s likely worked, I just don’t think it’s the best long term solution.
Mushroom distillate from dink is all I’ve seen for long term. Those bags of powder from villa too.
3 Likes