Playing with Acids and Bases need to be done with precaution. to little will not have an effective result, too much and you will have unwanted reactions, leading to degradation of the desired API (Actibe Phyto/Pharma Ingredient).
The same way that the PH of the Oil in the Pot will affect Isomerization during Distillation, leading to (Either Unwanted or Desired) THC conversion into other cannabinoids; I have identified free radical formation, and subsequent conversions, side reactions, oxidation and degradations that occur During harvest, extraction, winterization, distillation, and chromatography. So always good to trust the science, but verify with lab results Often.
For Example, Chromatographic separation of cannabinoids can be done with majors and minors isolated using basic solutions, however too much base can lead to Saponification of the Fatty Acid chains (Saponification is the conversion of Oils into Soaps as ‘described’ in the Movie Fight Club). I would Avoid going above PH12 for this reason with non refined oils.
CRC media, among other Physical characteristic’s, often use a Slight charge (Acidic or Basic) to ‘attract’ the undesirable compounds, while letting the cannabinoids pass through.
With that said, there is still a massive field of research yet to be fully elucidated, in terms of using Polarity to purify cannabinoid APIs, in addition to the Solubility, freezing / boiling points, and physics currently used in extraction. Isolates and contamination remediation has thrown the doors wide open, but fear / ignorance and lack of experience has kept us in the dark ages
As the industry transitions from Purely extraction into biochemically semi synthetic cannabinoids