Water-Soluble, Instant-Acting SOP for Noids and Various API

Data Dump Cannabis Papers
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Happy Holidays fam!

Please keep the discussion productive and civil. I apologize for my hiatus and i am glad to return. Since my absence I have worked on this SOP behind the scenes with @Photon_noir and multiple holistic/scientific co-ops. The methodology here is thoroughly tested and repeatable. However, there are still many caveats pertaining to production and application. As promised, here’s your SOP….

Standard Operating Procedure (SOP)

Baseline Phospholipid Emulsion

Purpose:

This SOP outlines a basic, experimental framework for producing a wide-spectrum phospholipid emulsion capable of incorporating a broad range of active pharmaceutical or botanical ingredients (APIs).

This document is not a finished formulation. It intentionally omits optimization, stability controls, regulatory considerations, safety validation, API-specific constraints, and downstream adaptation pathways.

It is provided as a conceptual and practical starting point only.

Reference Batch Size

Standardized batch using 10 g total

API

Materials:

Lecithin(granules or powder)

Ethanol(95%)

Distilled water

Citric acid

Vinegar@5%(acetic acid source)

Sodium hydroxide

Sugar(organic cane sugar)

API(s) of choice

Guanylate-infused oil(see Footnote)

Equipment:

Four 8oz mason jars with new lids

Oven

Thick-bottom pot with glass lid (for water bath)

Infrared / laser thermometer

Well-lit, well-ventilated workspace

Procedure:

1. Lecithin Hydration

Add 25 g dry lecithin to each of two mason jars.

Slowly mix 40 g cold distilled water into each jar until fully wetted.

Seal jars and refrigerate for 2 hours.

Lecithin should be fully hydrated with no dry pockets.

2. API Solution Preparation

Dissolve 10 g API into 200 g ethanol.

Add 5 g guanylate-infused oil and mix until fully dissolved.

Slowly dilute with 20 g hot distilled water, avoiding precipitation.

Seal and set aside.

3. Initial Lecithin Activation

Remove one hydrated lecithin jar from refrigeration.

Place in a 120°F (49°C) water bath until internal temperature reaches 100°F (38°C).

Gradually raise bath temperature to 150°F (66°C) until internal temperature reaches 130°F (54°C).

Heating must be gradual to preserve phospholipid structure.

4. API–Lecithin Layering

Divide the API solution into two equal portions.

Heat one portion rapidly to 150°F (66°C).

Carefully float this heated API solution on top of the warmed lecithin without agitation.

Seal the jar and place it in an oven set to 170°F (77°C) for 15 minutes.

Jars must remain vented to avoid pressure buildup.

Remove and gently swirl to homogenize.

Increase oven temperature to 200°F (93°C) and heat for an additional 20 minutes.

5. Acidification Phase

Prepare two heated solutions:

Vinegar: 10 g vinegar + 20 g water + 20g sugar(sugar is optional if using orally, dissolve fully), heated to 150°F

Citric acid: 5 g citric acid + 30 g water, heated to 150°F

Add vinegar solution drop-wise to the main jar while maintaining temperature.

Gently swirl to homogenize.

Repeat with citric acid solution.

Return jar to oven at 170°F (77°C).

6. Secondary Lecithin Integration

Heat the second lecithin jar gradually to 100°F (38°C).

Add 10 g guanylate-infused oil and gently mix.

Carefully pour this mixture into the main jar, allowing it to settle naturally.

Let sit for 10 minutes for temperature equilibration, then gently swirl to homogenize.

7. Final API Addition & pH Adjustment

Heat the remaining API solution to 150°F (66°C) and add 5 g guanylate-infused oil.

Float this mixture onto the main jar and allow to equilibrate for 5 minutes.

Gently swirl to combine.

Prepare 2g sodium hydroxide in 10 g warm water (120°F).

Slowly swirl into the mixture.

Measure pH; target pH 7–8 to stabilize the phospholipid system.

End State

At this point, the phospholipid emulsion is considered complete in its base form.

From here, it may be:

Bottled as-is

Converted into oils, low-ethanol liquids, powders, or crystalline forms

Adapted for culinary, topical, or other experimental applications

Each pathway requires additional design and control considerations not covered here.

Important Notes:

This SOP does not address safety, legality, dosing, stability, or suitability for human use.

Temperature control, lipid chemistry, pressure management, and API compatibility are critical variables that must be handled deliberately.

This document is intentionally incomplete.

Footnote:

Guanylate-Infused Oil

Functional Additive

The guanylate-infused oil used in this procedure serves two primary roles:

1. Antioxidant buffering, reducing oxidative stress on phospholipids and dissolved actives during repeated thermal cycling. 2. Thermal insulation and lipid-phase stabilization, improving tolerance to temperature transitions and prolonged heat exposure.

The oil is prepared separately by gently simmering approximately 1 lb (450 g) of finely chopped fresh shiitake mushrooms into 75 g of oil (butter, ghee, or another oil of choice), selected based on desired flavor profile or additional lipid-soluble compounds. You will need to recycle the oil while cooking 100~gs of shiitake at a time. Also, make sure to separate milk solids if using butter.

Preparation method:

Simmer on low heat covered for 30 minute. Sprinkle in 4gs of sea salt. Continue simmering uncovered for an additional 30 minutes. Increase heat slightly and watch until the mushrooms are lightly caramelized(the fungus odor will dissipate and get replaced by a sweet smell, the oil will also become foamy when the mushrooms are perfect) Remove from heat and strain solids from the oil. The clarified oil is reserved for use. The cooked shiitake and milk solids are highly recommended for consumption after straining.

This infused oil functions as a supporting excipient, not an active component. Alternative antioxidant lipid systems may be substituted depending on formulation goals.

This SOP represents only the structural skeleton of what is possible with phospholipid systems.

Adapting this method for:

Specific APIs or compound classes

Improved stability or shelf life

Reduced ethanol or heat exposure

Scaled production

Conversion into durable oils, powders, or crystalline forms

Culinary, topical, or other unconventional delivery systems

…requires experience, judgment, and case-by-case modification.

The end goal is to create a suspension of preserved upper liquid-crystalline phase phospholipids, lipid hydroperoxides(HDL), and lysolecithin. The entire mixture should be saturated with antioxidants and the API can be contained in multiple compartments, or isolated in specific areas. This is a micellar formula that can suspend lipid hydroperoxides and hydrophobic API using lysolipids and lecithin particles. Acids are used to create lysolecithin and then sodium hydroxide is used for saponification and sodium citrate formation. The final solution will behave like a non-foaming detergent. It works great in the raw form as a soap or a drink additive. And no, it isnt caustic to tissue because it has a safe pH and it is packed with phospholipids that actually act to restore lipid motility. This blend can repair gut lining scars and facilitate rapid uptake of any nutrient(s) or drug(s) consumed within 2 hours of administration. Oral solutions and topical solutions can drastically potentiate any other narcotic substance, be warned. The formula is odd in other ways too, it can make cbd feel extremely psychoactive. And it creates a very unique feeling of movement and physiological satiation. IMO it feels like some kind of electromagnetic acetylcholine stimulation. I believe there could be some subcutaneous electrical magic occurring here and I’d love to hear input from more experts on what may be occurring. Once you consume this stuff you are never the same, and I don’t say this lightly. I am a self-avowed psyconaut with almost no ceiling. I’m a dead-lot kid and I’ve been thumbprinted…and I’d put this stuff right up there with the significance of that experience.

Procedural Notes:

Make sure everything is temp matched when adding any ingredients to lecithin mixtures. Add everything drop-wise, unless stated otherwise. Avoid aeration of the mixture at all points. Complete each step and make sure temp goals are achieved. Jars will heat from outside to inside, be careful when applying heat to outside of jar. Phospholipids can denature at low temps and they do not like to be rapidly heated, hydrated, or coaxed into any state forcefully. Patience and observation are your best allies here. Prior to acidic additions, the mix needs to be de-gassed and in a state of transparency. When phospholipids are in their upper phase transitions, they tend to shine with an iridescent glow. Avoid any drying against jar walls, or drastic uneven heatin. Lecithin once hydrated will display non-newtonian properties, do not attempt to defeat these through shear force. We are building delicate micellar structures that require a certain level of homeostasis to form properly. Cellular walls act as dialysis membranes, not filters. Many liposomal/ethosomal products are created with extrusion and high rpm shear, we want none of those anywhere near this process. Also, this procedure requires ZERO synthetic chemicals or questionable additives. IMO, it is superior to any nano blends available. This isn’t a nanotized format designed to pass through tiny spaces. This an adaptive mixture that takes tissue interface dynamics into consideration. Particles in a balanced matrix of highly mobile phospholipids will self organize as they pass through tissue.

This SOP is designed to create instant acting, water/oil soluble solutions that can be used transdermally, orally, or through any orifice. The ethanol, water, pH, and oil content can all be adjusted to suit any format. A variety of ingredients can be substituted and methodology can be adapted to fit almost any environment. If you are experimenting with this framework and want help adapting it to your specific needs, or if you are trying to understand why certain steps matter rather than just how to perform them, you are encouraged to reach out directly to me. I will make myself very available until this procedure is understood and performed accurately. My intention here is to seed advanced tech while building relationships with potential collaborators. If one were inclined, they could use this tech to build an empire in any environment that is friendly to cannabis/kratom/kava/etc. Also, when paired with superfoods and dietary nutrients, this formula will facilitate massive health improvements. I’m 38 and I’ve used it almost daily for 10+ years. It has completely repaired my gut lipid scarring, fixed my eyesight, put my metabolism in a wild place, and caused sooo many more positive results. I stay at 8% body fat with almost no exercise and I don’t contract any common illnesses. Some of my friends think I’m some kind of Wolverine type character, lol. But it’s all science that I can, and will, happily teach to anyone interested. I’m obviously a human with bills n’ such, but money isn’t a big part of this discussion. I am here to share and enrich our beautiful community of holistic healers. Paying my bills is a second priority, and always has been, in regards to this tech. However, I am available for hire for proprietary applications, scaling, and adaptations into novel formats. I also operate as a full time consultant for operations pertaining to production of holistic products. I have been performing herbal/cannabis science for over 20 years and I love to travel around sharing my knowledge. I hope that anyone reading this is having a happy holiday season, and I look forward to the conversation this will inevitably stir up:)

-Miah Leffingwell

9 Likes
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Why not use an ultrasonic cleaner ? There is ample evidence of people do so with vitamins at home

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This is a bit more complicated of a system than basic micellar drug delivery. These are also highly hydrophobic api. The objectives of each step are all interwoven to build a functional instant acting api. Liposomal products are cool, but they are about 50 years behind this tech

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Here’s some of my rationale for each step of the methodology:

Scientific Mission Framework

Instant-Acting Cannabinoid Phospholipid Emulsion

Document Purpose and Scope

This document serves as a scientific mission, mechanistic interpretation, and conceptual companion to the procedural SOP titled Baseline Phospholipid Emulsion — Experimental Template.

It does not alter procedural steps. Instead, it formalizes:

  • Scientific intent at each stage

  • Mechanistic hypotheses grounded in lipid chemistry and delivery science

  • Structural rationale for sequencing, thermal control, and pH cycling

All mechanistic descriptions are framed as working hypotheses informed by established principles, empirical behavior, and formulation logic, not as claims of proven biological effect.

Global Scientific Mission Statement

The mission of this formulation strategy is to construct a pre-organized, multi-phospholipid cannabinoid delivery architecture designed to achieve rapid onset through structural pre-association rather than reliance on endogenous digestive emulsification.

Key design principles include:

  • Early association of cannabinoids with lipid domains prior to phospholipid capture

  • Controlled phospholipid activation and reorganization via thermal gradients

  • Strategic pH modulation to induce restructuring without collapse

  • Formation of a lysolecithin-dominant emulsion capable of dynamic phase interchange

The intended end state is a structurally adaptable emulsion that remains functionally compatible across:

  • Oil-based systems

  • Aqueous and low-ethanol systems

  • Mildly acidic matrices

  • Topical lipid barriers

  • Culinary fat and heat environments

Stepwise Scientific Mission and Mechanistic Elaboration

Procedure 1 — Lecithin Hydration

Scientific Objective
To fully hydrate phospholipid assemblies while preserving their native lamellar potential, establishing a responsive structural scaffold.

Mechanistic Interpretation
Slow hydration in cold water allows phosphatidylcholine-rich lecithin to absorb water into polar headgroups without inducing premature micellization. Refrigerated rest time enables uniform multilamellar expansion and minimizes internal stress gradients.

Design Rationale
Hydrated phospholipids prepared in this manner retain the ability to later transition between bilayer, vesicular, and lysolecithin-associated states under controlled stimuli.

Failure Mode Avoided
Incomplete or hot hydration produces inert emulsifiers that resist later reorganization.

Procedure 2 — API Solution Preparation

Scientific Objective
To dissolve cannabinoids into a solvent–lipid environment that promotes early hydrophobic association prior to phospholipid exposure.

Mechanistic Interpretation
Ethanol temporarily suppresses cannabinoid crystallinity while the lipid phase provides a hydrophobic anchor. Gradual hot-water dilution increases polarity without triggering precipitation, encouraging cannabinoids to partition preferentially into lipid-associated states.

Design Rationale
Cannabinoids that associate with lipid domains prior to phospholipid contact integrate more efficiently into membrane structures and resist later phase separation.

Procedure 3 — Initial Lecithin Activation

Scientific Objective
To thermally activate hydrated phospholipids into a fluid, receptive state without structural degradation.

Mechanistic Interpretation
Gradual heating transitions phospholipid bilayers from gel to liquid-crystalline phases, increasing lateral mobility and hydrophobic tail accessibility while preserving lamellar integrity.

Design Rationale
Activated phospholipids behave as adaptive membranes rather than static emulsifiers, enabling controlled capture of cannabinoid–lipid complexes.

Procedure 4 — API–Lecithin Layering

Scientific Objective
To enforce controlled interfacial diffusion between cannabinoid–lipid complexes and activated phospholipids.

Mechanistic Interpretation
Density and temperature stratification create a stable interface where directional diffusion dominates over turbulent mixing. This favors localized membrane reorganization around incoming hydrophobic domains.

Design Rationale
Layered integration promotes organized association, which is hypothesized to correlate with faster dispersion and onset compared to chaotic emulsions.

Procedure 5 — Acidification Phase

Scientific Objective
To partially destabilize existing phospholipid assemblies and induce structural reorganization.

Mechanistic Interpretation
Mild acidification protonates phospholipid headgroups, reducing electrostatic repulsion and promoting membrane thinning, partial hydrolysis, and transition toward smaller, more dynamic assemblies.

Design Rationale
Controlled destabilization increases cannabinoid embedding depth and primes the system for lysolecithin-mediated interchangeability.

Procedure 6 — Secondary Lecithin Integration

Scientific Objective
To rebuild and expand the phospholipid network around the reorganized core system.

Mechanistic Interpretation
Fresh phospholipid input restores membrane mass and stability while accommodating cannabinoid-loaded structures formed during acidification.

Design Rationale
This step converts a destabilized intermediate into a reinforced, flexible architecture with higher loading capacity.

Procedure 7 — Final API Addition and pH Adjustment

Scientific Objective
To complete cannabinoid saturation and lock the system into a stable operational pH range.

Mechanistic Interpretation
Final basification restores phospholipid charge balance, reduces hydrolytic risk, and stabilizes lysolecithin-rich structures.

Design Rationale
Neutral pH maximizes phospholipid longevity and prepares the emulsion for downstream conversion.

Conceptual Diagrams (Text Descriptions)

Figure 1 — Phospholipid Hydration and Activation
Illustrates transition from dry lecithin aggregates to hydrated multilamellar structures and thermally activated fluid membranes.

Figure 2 — Cannabinoid–Lipid Pre-Association
Depicts cannabinoids partitioning from ethanol into lipid domains prior to phospholipid contact.

Figure 3 — Layered Interfacial Integration
Shows stratified API and lecithin phases with directional diffusion across a stable interface.

Figure 4 — pH-Cycled Structural Reorganization
Visualizes membrane thinning during acidification followed by reinforced assembly after secondary lecithin integration.

Figure 5 — Final Multi-Phase Interchangeability
Represents the completed emulsion transitioning between oil, aqueous, acidic, and topical environments.

End-State Interpretation

The completed system is best understood as a pre-organized lipid delivery architecture rather than a simple emulsion. Rapid onset is hypothesized to result from reduced dependence on physiological emulsification, enhanced membrane affinity, and immediate dispersion at mixed-phase interfaces.

Notes on Use and Disclosure

This document is intended for internal R&D, controlled technical communication, and formulation development contexts. It does not constitute clinical, safety, or regulatory validation.

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Or here’s more details

Scientific Mission Framework.pdf (179.9 KB)

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there is a real kernel of lipid-delivery chemistry here, but the document as written is ~70–80% bullshit, mostly because it layers mysticism, misused terminology, and implausible biological claims on top of a loosely coherent emulsification process.

I can also use chatgpt

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Thank God you’re here. I thought the armchair scientists were all dead here. Please tell me why any of this is bs. I think you are the one who is bs. But please elaborate, or don’t. Either way, nobody is listening to either one of us. But the difference between me and you is that I create real world items, not internet banter

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Yeah, not like I’ve ever shared anything that could actually be replicated or anything

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Then we agree, you suck and I am great. Why don’t you just let me share my inventions? I could totally hire a witch doctor to cast voodoo at you. I could even nanotize and encapsulate the main api in his voodoo sticks. You should quit bringing your loose butthole into tight situations

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Nah, you can’t do anything

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You know, this whole project didn’t arise from hollow concepts. I have been assembling this methodology for 15 years now. And I’m always upgrading and expanding it. I use chatgpt for formatting. But this is all full functional, proprietary methodology created through a collaborative effort with multiple experts from related fields. This stuff works and it is a wild experience that can heal almost any condition. Look at my Instagram @phorventi if you wanna see what it can do for health when paired with a healthy diet. Im a goofball and vocabulary is odd. But i have produced these experiences for hundreds of people, and I continue to do so almost daily. Try the methodology before you knock it. Remember, I proved it in a lab in a previous thread. I show up when challenged

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@CellularSecrets thinks this will turn you into Wolverine, he is obviously high on some very good crack.

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Pseudoscience does require at least a kernel of truth

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Perhaps you could go back 3000 years in time and reduce the entire “op” to a single sentence.

  1. Mix AIP with fresh goat curd and eat.

It took Mother Nature about 1/4 billion years to develop current versions of mammalian milk. If you look closely at your approach , you might just market that SOP as a baby formula.

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Don’t be jealous of my sexiness. BTW, thank you guys for showing up. I needed this turmoil to help get people to pay attention to this badass SOP

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Could probably make a killing marketing this to the anti-vax crowd, to turn their babies into Wolverine, so they don’t have to worry about vaccinations anymore.

I am hearing it all the time how some of these people are super suckers.

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You know I make a cream for dudes with weak balls and low self esteem? It would be perfect for you and your horse

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Did you make that one for yourself first?

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Does this cream also cure herpes?

It supposedly heals “almost any condition” so is herpes included in that list?

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be nice.

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