Mods feel free to move this as I’m not sure this is the most appropriate but best guessed sub.
TL;DR at bottom, this is a kinda long one.
In my quest for research in a new venture, CBD/CBG/CBN tinctures, I discovered this place about a week ago. I’ve been gleaning what I can and have realized there is a high density of highly intelligent individuals here. Finding a forum like this feels… wrong, like it shouldn’t exist and even as a new user understand how awesome of a resource F4200 is!
To that end I actually registered, which is really rare, and am dipping my toes in per se by inquiring your great collective knowledge.
I’ve been trying to get into larger scale organic, regenerative cultivation for a few years but that plan is more a long term goal and may need a few more to come to fruition. In the meantime and after a lengthy discussion about pursuing something in the hemp/cannabis industry with my father(used to sell medical equipment - blood cell analyzers and drug testing) we decided that we should try to offer a high quality, liposomal, ultra high concentration product at a much more affordable price point than the market currently offers consumers.
Our highest concentration product goal is around 8-10g of active be it CBD, CBG, CBN(all isolates) or a combination thereof, encapsulated with a phospholipid complex from third party tested, deoiled sunflower lecithin powder in a third party tested grapeseed oil base.
The next step we’re starting to mess with is sonication. After reading quite a bit from Hielsher and pubmed documents we figured it would be a decent step towards producing a partially or largely “nanified” product. We’re not trying to make or have any current interest in a water or water soluble product. Merely upping the bioavailability as far as oral absorption, onset, overall efficacy, digestive protection and duration of the active in a typical oil tincture is our goal as historically a lot of the products on the market consumers are exposed to are kind of shit.
We have been using our hotplate/mag stirrer to combine all the ingredients(lower concentrations for testing purposes) after that we’ve been sonicating with a U.S. Solid 20kHz 450w probe at 65% amplitude. I think this may be too much amplitude as this has oxidized and burnt something in the oil as it smells of a lightly fishy, overheated electronic device type of smell. We removed the active and same smell, removed the lecithin and same smell in pure grapeseed oil. I believe this is a common problem after reading some articles, some on here even.
Before I head down a path of wasting our resources just busting out different mixtures in various steps I implore your knowledge as to my next best step(s)
TL;DR - How possible is achieving a high concentration(8g+) nano scale(100-500nm), oil based(no water at all) tincture using isolates, sunflower lecithin and grapeseed oil with access to an ultrasonic probe homogenizer?