Hello science fans. After tons of testing, I have found a way to create instant-acting cannabinoids with a very low failure rate. My previous SOPs were laden with unnecessary steps, primarily due to my incomplete understanding of what mechanism made my edibles so unique to begin with. After my last foray here, I was a bit distraught about this issue. I tried to study the mechanism further, but to no avail. So I decided that I needed to do tests on the function of every step of my process. And after a slew of tests, I developed this:
INSTANT-ACTING THC SOP USING PHOSPHOLIPIDS AND SUGAR:
Test Batch size of 20g api. This is just a reference batch, these ratios can be scaled up or down. The ratios can also be altered. Ethanol can be substituted for isopropyl, with some minor modifications. But this sop uses isopropyl because it’s way easier to work with. The final product contains no isopropyl, but I know some people want to avoid the fumes from iso. I’ll post the ethanol recipe soon, but try to work with this for now.
INSTANT ACTING THC USING PHOSPHOLIPIDS AND SUGAR
COMBINE BOTH FORMULAS FOR FULL FUNCTIONALITY
This ingredient list is shared between 2 batches. The first recipe is designed to produce a broad spectrum of phospholipids with a surfactant tendency. The second recipe creates a broad spectrum of phospholipids with a detergent tendency. They can be consumed together or alone, and I recommend you experiment with them individually. The surfactant recipe is better for topicals that get left on the skin, ethanol containing tinctures, and infusion into various cooking oils. The detergent recipe works better in non-oily foods, soaps, drinks, highly acidic mediums, and things that you want to foam up. Each recipe is saturated with antioxidants to ensure that ROS aren’t injected into the intracellular membrane. And I recommend experimenting with different antioxidant sources/quantities. For example, if your final product intends to contain high quantities of acids, then you can substitute Vitamin C for Guanylate. There’s alot of ways to tweak this format, and one can achieve various unique pharmacokinetics and solubilities by doing so. The sugar is also only present to function as a heat-tolerant dry crystalline adsorbent, feel free to substitute it for anything with similar characteristics. The real rub here is this: Make an emulsion, clarify it, and then pour it into a heated medium that rejects your solvent, adsorbs your water, and provides a path for phospholipids to striate into fractions. Crystalline sugar is chosen for this task because it exhibits all the proper characteristics, but salt and various absorption methods can be used. The key thing is to rapidly heat the emulsion while it rests in a hygroscopic medium that won’t allow any pooling during any part of the process. Ensure you’re using dewaxed cannabinoids for max effectiveness. And most importantly, have fun!
Recipe 1 and 2
20g API(noids!)
100g Dry Soy Lecithin
220g MCT oil
10g Vitamin E
75g Distilled water
400g 99% IPA
3g Sea salt
300mg guanylate
Side note:
Guanosine monohydrate is preferable for a guanylate source, but disodium guanylate can be used in a pinch. A water based extraction from dry shiitake can be utilized to acquire the monohydrate, it takes roughly 200 grams of dry shiitake to get 300mg guanosine monohydrate. I’m not entirely sure how it works, but the guanylate causes a feeling of rejuvenation. It could be from some type of antioxidant property, but I’m not educated enough to speculate much here.
RECIPE 1(lysolecithin micelles):
5% vinegar 50 g | citric acid 2 g
RECIPE 2(transfersome):
omit vinegar + citric acid
EQUIPMENT
oven/convection oven
Second warming space/oven
High-walled Pyrex dish
Mason jar + fresh lid
Ziploc bag
Laser temp gun
Scale
- LECITHIN HYDRATION — 24 HR AHEAD
Add 50 g refrigerated dry lecithin to ziploc bag
Add 50 g distilled water gradually
Gently knead until no dry spots.
Push out air, seal bag, refrigerate 24 hr.
Before use: remove from fridge, bring to room temp.
- API ALCOHOL MIX
Add 10g API to 200g 99% IPA
Warm gently to about 100°F
Mix until API fully dissolves
Add 3g sea salt
Add 10g MCT oil
Mix uniform. Keep warm/set aside.
- LIPID ADDITIVE MIX
Combine 100 g MCT oil + 10 g vitamin E
Mix uniform. Set aside.
- SUGAR BED
Place 500 g sugar in high-walled Pyrex
Use dish size that gives several-inch-deep sugar bed
Heat in oven at 280°F
Confirm sugar bed temp with laser thermometer
- LOOSEN HYDRATED LECITHIN
Mix 25 g distilled water with your guanylate source and add to hydrated lecithin
Gently knead in bag
Let it rest for 5 minutes
Add 20g@100f API alcohol mix
Gently knead
Rest 10 min
Add another 20g@100f API alcohol mix
Gently knead until pourable.
- TRANSFER TO JAR
Pour lecithin mixture into 100f preheated mason jar
Warm jar in oven or water bath til internal temp reaches 120-130
Keep lid loosely sealed so it never produces more than 1-2psi
- ADD MORE API ALCOHOL MIX
Remove jar from heat
Gradually add 100g@100f API alcohol mix
Stir gently but avoid any aeration.
Loosely seal cap again
Return to heat source until internal temp reaches 120-130
Allow to sit for 20 minutes
- ADD HALF LIPID ADDITIVE MIX
Remove jar.
Add about half of MCT/vitamin E mix
Stir gently
Loosely seal cap jar
Maintain 120-130f internal temp
Recipes 1 and 2 are identical until this step, they branch off right here.
A9) ACID MIX
Combine 50 g vinegar with 2 g citric acid
Stir until dissolved
Heat to 120f
Set aside
A10) ADD ACID + REMAINING ALCOHOL MIX
Combine remaining API alcohol mix with vinegar/citric acid mix
Heat to 120–130°F.
Slowly add into main mason jar
Stir gently, avoid aeration, maintain temp
A11) CLARIFY
Warm jar til internal temp reaches 130-150°F.
Allow mixture to clarify; may take 10–40 min
Do not remove from oven til it clarifies completely, adjust temp and jar pressure to achieve this, just be careful, you never want more than a few psi to form
Do not shake
Once clarified, proceed
A12) ADD TO HOT SUGAR
Remove hot sugar bed from oven.
Pour remaining MCT/vitamin E/guanolate mix evenly over sugar
Slowly pour clarified jar mixture over sugar
Pour gently/evenly; avoid splashing/aeration
Keep face away from vapors
POUR VERY GENTLY AND DO NOT ALLOW THE MIXTURE TO MAKE CONTACT WITH ANY PART OF THE DISH
Adjust pour rate accordingly to achieve this and ensure to coat the sugar as evenly as possible
If done properly, the solvent should be completely gone at this point, but there will now be water in the sugar crystals, so we have one last step
You want to ensure that the formula doesn’t melt the sugar crystals, they won’t dry properly if you allow them to dissolve
Move as fast as possible during these final steps
A13) FINAL HEAT
Return sugar dish to oven.
Heat until sugar bed reaches 260°F
Remove from oven
Let it cool in a dry environment for 1 hour(dehydrator preferable)
A14) BREAK UP / SIFT / LABEL
When cool, break clumps gently
Do not crush sugar crystals more than needed
Homogenize batch
Sift if needed for even particle size, but avoid crushing into powder
Store and label “Recipe 1”
RECIPE 2— NO VINEGAR / NO CITRIC ACID
B9) SKIP ACID STEP
No vinegar. No citric acid.
B10) ADD REMAINING ALCOHOL MIX DIRECTLY
Add remaining heated API alcohol mix directly into main jar
Stir gently, avoid aeration, maintain temp
B11) CLARIFY
Warm jar til internal temp reaches 130-150°F
Allow mixture to clarify; may take 10–40 min
Do not remove from oven til it clarifies completely, adjust temp and jar pressure to achieve this, just be careful, you never want more than a few psi to form
Do not shake
Once clarified, proceed
B12) ADD TO HOT SUGAR
Remove hot sugar bed from oven.
Pour remaining MCT/vitamin E/guanolate mix evenly over sugar
Slowly pour clarified jar mixture over sugar
Pour gently/evenly; avoid splashing/aeration
Keep face away from vapors
B13) FINAL HEAT
Return sugar dish to oven.
Heat until sugar bed reaches about 260°F.
Remove from oven.
Cool fully at room temp.
B14) BREAK UP / SIFT / LABEL
When cool, break clumps gently.
Do not crush sugar crystals more than needed.
Homogenize batch.
Sift if needed for even particle size.
Store and label “Recipe 2”
Final blends can vary in ratio, just be aware that you need atleast 20% detergent blend to prevent the surfactant blend from causing excessive tissue gumming. If the formula gums up it will lose it’s effectiveness and cause a slimy film. Play around with different ratios to see what you like. The lecithin to api ratio can be altered to produce various flavor profiles as well. At 6:1 or above dry lecithin to api, you will stop noticing the api’s flavor. Anything below that will taste increasingly more bitter til you reach about 3.5:1 dry lecithin to api ratio, at that point the mechanism of action begins to malfunction. Although, I have seen formulas as low as 2:1 still retain water solubility and high bioavailability. But we are looking for more than just water solubility or high bioavailability here. Something magical starts to occur in the nervous system at ratios over 3.5, and the effect seems to fully max out around 8:1. You’ll know exactly what I mean once you try it. Good luck!
And here’s a tldr rant about why I do all this:
The reason I’ve released my tech for free hasn’t changed since my first post. This tech is a gift in my life and it has completely cured things that seemed incurable(multiple infectious diseases and my gut lipid motility). The traits it exhibits are beyond description to those who’ve experienced it. I’ve made thousands of batches while employing methods with extremely high failure rates, and i did it all so I could chase this magical anomaly i found 15 years ago when I accidentally made my first batch of this stuff. I have no formal education and I never intended to develop anything like this, atleast until I saw deep suffering in a loved one. People who know me are aware that I married a woman who had Lyme disease in my early 20s. At the time, I had no idea what lyme even was. Several months into our relationship she progressed into late stage Lyme disease and started experiencing seizures, rapid weight loss, along with a plethora of other crazy symptoms. I watched helplessly as she wasted away in front of me, until one day I convinced her to hit some weed in a bong. Her fingers were curled, her eyes were lazy, she couldn’t walk, and I figured it couldn’t hurt to try anything. I had watched a documentary about weed stopping seizures and I just wanted to stop her seizures. So i loaded some og, and after she took that hit she stood up, uncurled her fingers, and told me to get her some food. These are things she hadn’t done in months, I was blown away. She started smoking daily and I was even more shocked when she fully regained mental clarity, stopped having seizures, and started gaining weight within a week. She had a miraculous recovery that got better and better, til one day it didn’t. The weed began to quit working as her tolerance built. She slowly slid back into seizures and wasting syndrome. And after so much I couldn’t stand to just accept that the weed only worked temporarily. So, I started studying chemistry, biology and various drug delivery technologies. I was a sponge and I stayed up long nights eating shrooms and studying every perspective I could on the subject. I prayed and cried constantly during this period. My life was shit and this girl was my whole world, I refused to lose her to this b.s. CIA created disease…that’s another rant for another time…But, after a bit of studying, I found some papers from the 70s about liposomal encapsulation and the massive promise it held. Then I started studying how gpcr receptors can can retreat into the intracellular membrane in a process known as endosomal reticulation. I also studied first pass metabolism and enzymatic deactivation of ligands. And once I grasped enough biology, I began to see a solution. I had to learn so much terminology to even read these papers because I am a high school dropout and all I was ever good at was mechanical devices, computers, and internal combustion engines. But I absorbed enough to start doing experiments using phospholipids and cannabinoids. My original understanding was shit and I made hundreds of batches that did nothing. But, then one night I made a solution that I poured into a pot full of hot essential oils. And when I reached down to touch it after stirring it, i got ridiculously high instantly. A finger dip sent me to the floor in a blinding white out and i started seeing geometric patterns all throughout my visual field. I closed my eyes and had a wild experience that can only be described as highly entheogenic. After about 15 minutes I was able to stand, and when I did I immediately knew I had to give this to my wife. So I did, and it immediately brought her back to the fully healed state that weed originally brought her to. She was hooked on the effects, and I was addicted to the idea of this novel mechanism. So I tried to make it again, and I immediately hit multiple issues. I had not documented the original methodology and I couldn’t remember everything i did. I only knew what ingredients I had used and the quantities. But I kept trying because I knew I had discovered the answer to her problems. And after about 100 more batches, I was successful at recreating the same effect, but with a cookie this time. That let me know i could create this effect in an edible or a topical. So I kept going and making batches using a poorly refined method and kept studying science. My original method was only successful about 1 out of 5 tries, and it would only stay active for about 24 hours after production before it would quit working completely. So, id have to make batches all day and night while immediately testing each of them on myself(and my stoner friends)until one would work good enough, and then I’d immediately rush it to my wife. This went on for about 6 months before she completely recovered. She has now exhibited no symptoms for 12 years, and she is in exceptional health for her age. After her recovery we were completely broke and our families had both excommunicated us for using weed to treat her. We both basically came from families that were heavily involved with fundamentalist Christian cults, and they both had a no-tolerance policy for any substance, especially weed. So we were infinitely grateful, but stranded and stuck in a cold world with no careers or money. I kept refining the tech endlessly and it slowly got better over the years, but it profited me very little money and slowly drove me deeper into poverty and lunacy. Eventually I got involved in some crazy weed smuggling things and got arrested and put in prison down in Texas for a few years. She left me while I was locked up. My wolf died and I lost everything I owned. It was just like a country song. But, I walked out with the knowledge that I had discovered something truly magical. So, I kept working, and working, and fucking my wasted life up even more…but then I saw that light again, albeit, with lots of help from the indole goddesses. And I’m proud to say that I cracked it wide open about 6 months ago, finally. And I think that’s enough speech of my genesis. Just know that this thing came to me and it’s made for you, and you, and you, and all the sick little people who need it. So, flame me if you’d like. But just know that I am not a trained scientist and I didn’t decide this path, I’m 39 now and it’s all I’ve done for the past 16 years. I’m here for those who need me, and I’ll endure those who fight me. I love the people who latched onto me when I posted my cellular wafers thread. I was planning to permanently disappear from society after I posted that thread. I was desperate and lost, and only I had produced this tech. I halfway thought it was all one big hallucination. So I posted everything I knew because I thought some smart people on here might finish what I started. But, the immediate response I got made me stick around to answer questions. And to my amazement, several people made the magic successfully. After that I knew it was real and teachable. So I was renewed. But I also knew it was super clunky and very unreliable. I couldn’t really adapt it to new equipment or spaces. I tried to rapidly educate myself and failed when I was put on the chopping block in Eugene. But @photonoir latched onto me and taught me sooo much. He believed in me and so did several others, and that’s the only reason I’m here posting this SOP today:)
