THCV, or tetrahydrocannabivarin, is a cannabinoid found in cannabis with unique interactions at the CB1 receptor, a key component of the endocannabinoid system. Unlike THC, which typically activates CB1 receptors, THCV acts as an antagonist or inverse agonist at these receptors at low doses, potentially blocking THC’s effects. This antagonism can lead to appetite suppression and might contribute to neuroprotection. However, at higher doses, THCV shifts to partial agonism, mimicking some THC-like effects. This dual action makes THCV a subject of interest for therapeutic applications, including weight management, diabetes, and neurological disorders, by modulating CB1 receptor activity.
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THCV for weightloss is interesting. its like ozempic but without the blindness and failing livers lol
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or not like Rimonabant with side effects such as depression and suicide. that was scary stuff, it got introduced and recalled right when i took pharmacology classes and our Professor only had the highest praise for it. he was a weird dude, he self prescribed diuretics without any actual need for it and he always looked like a freeze dried Andrew Tate
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I lost 100+ lbs with black coffee lol thcv
Ive definitely heard great things about thc v
One of my clients has me make 10mg thc v gummies and he uses them in place of adderal for his adhd. He says thc v makes him hyper focused, reduces his appetite and gives him energy.
He hasnt used adderal in 3 years
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That sounds great, do you by any chance have other anecdotal evidence of these beneficial effects?
The one main thing I noticed about thcv was that it allowed me to go much longer into the day without eating. Whereas usually I would get kind of shaky and feeling strange (blood sugar?), with thcv it was like I was hungry but I could just ignore it for longer and felt fine being active and on my feet.
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Do you usually get cranky with low blood sugar? Personally i get nasty headaches if i go without food for too long, there was some research that the brain in males is much more sensitive to low blood sugar than in females.
Yes Rimonabant would seem to be the correct comparison as a CB1 antagonist. The inverse agonist data associated with Rimonabant is a bit dubious these days. (Redirecting) It seems to have ( non-receptor mediated) direct action on a subset of G-proteins. I think what is important here is understanding the subtleties of GPCR-receptor-action and the ability to modulate up or down. And I wanted to initiate some discussion about reverse agonism and neutral antagonists using THCV as an example. A modicum of scientific information is at hand. I was hoping for some first hand knowledge form readers of the forum for their experiences with THCV. Has anyone vaped this cannabinoid, THCV or vaped a rosin from a high THCVA strain?
@Kingofthekush420 provides a good example. When looking up the Cannabis strains that produce high levels of THCVA and THCV, I repeatedly find South African Strains, which are accompanied by comments concerning anti-appetite and weight loss and extra energy??? The appetite suppression action may certainly reflect some amount of reverse-agonism.
The cannabivirins are interesting as a special class of cannabinoic Acids, ( CBDVA and THCVA and CBGVA )
(https://doi.org/10.1111/bph.15842). Non cannabinoid receptor mediated pharmacologic actions.
It would certainly be nice to find a partial reverse agonist to mirror image the THC partial agonism of CB1. Perhaps THCV might be the one.
i would be very interested to procure CBDV or a plant with CBDV/THCV genetics, preferably from within Europe as importing seeds from outside of the EU is illegal here.
Yes, some people have these strains in USA, sometimes called “pink”?? or “red”??. This is for THCVA I don’t know of any CBDVA strains . THCVA should be relatively easy to purify based on its chromatographic qualities demonstrated with RP-C18 columns.
Lmao sounds like quite the character.
If a thcv or cbdv derrivative was found to be as or more effecive then any of those toxic ass weightloss drugs already on the market; it would change the industry over night, and probably not for the better.
A non psychoactive cannabinoid based weightloss drug; would probably be worth more then the entire industry combinded. Granted ya gotta spent like 100mm on clinical trials and all that jazz
Numbers in pharma go dumb; talking more revenue on a single product like that then some small country GDPs.
They would never let it be a “natural” molecule though, bet ya they would modify it such that it can be patented a dozen ways.
CBDA and CBDA/CBD mixtures for pain medication for elderly, already fits that bill.
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I have had several of HOKU’s strains and they are great if you need to get stuff done. Extremely energetic not a night vape.
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Thank you, And where can we find HOKU’s strains. Are seed available on the web. I have seen some ‘’THC/THCV “ ratios that suggest the material would be classified as marijuana not Hemp.
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i’d like to read the primary source for this claim @moronnabis do you have a PDF or link?
I would as well. That is just a summary I asked from GROK , It is not based on a literature search. Reading it my first thoughts were how was the THCV separated and was it contaminated with low levels of THC?
I take it,you can not find such a reference. I will look to verify as well. If none, we can certainly remove it. I also have some concerns of how it might interact with the allosteric CBD receptor site on CB1 at high dosage.
I found a few refs through the Wikipedia article. They seem legit
I see in the more recent literature references to partial agonism at high dosage seems to be absent. While confirming the antagonist /inverse agonist descriptions.
The first reference…was early, and difficult to understand in terms of high dose partial agonism.
We would have to look at a classical radar plot with time variation to even “set” or define what we mean by a “THC response” from a live cell prep as opposed to an isolate of the CB1 receptor monomer, and doing ligand binding studies . And then try to characterize the “reverse agonist effect”. Which implies we might be causing a cAMP levels to rise a bit , instead of decreasing, …or altered radar plot if we want to consider the entire spectrum of down stream action.
Honestly, I think there needs to be a new method of describing “down stream chemical activation networks” when it comes to “GPCR” action. The radar plot at a set point in time after drug application is one thing, but how the dynamics of these networks change in time domain is another thing. When you think about the subtle variation of “being high” on a hit of pure THC, as viewed from the internal, emergent-consciousness it gives on an appreciation of dynamics and complexity in concert.
In summary, we might scratch the partial agonism at high concentration concept for THCV on CB1. And, perhaps ask ourselves whether we have a meaningful way to describe the inverse agonist concept?
Classic binding studies with isolated receptors can define the neutral antagonist action.
Please advise further , and thanks.
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agree, and i’m very interested in this, but apparently GW Pharmaceuticals is already researching THCV and funding something like this is probably out of reach for most people here.
Maybe some empirical tryouts are in order then. Sadly, THCV is an NPS according to german law and if i can’t get a CBDV/THCV strain, i probably can’t realistically do anything of the sort without pudding myself at risk.