squig
September 4, 2021, 6:04am
10
I just punched in a post about that but decided to wait to see what
others come up with.
but yes there are ways to insert para to a phenol but before
isomerize CBD we have two para positions as we have two
phenolic groups.
on the separation idea I think there would be quite a difference in
polarity of the molecule if it was para or ortho.
both phenol and the carboxyl group are acidic and happy
to make ionic bonds. I would think there being in the
ortho (sorry put meta) position would change this effect more so than
in the para position.
im about to start digging for ways to form carboxyl groups as I have
nearly finished digging up isomerization refs.
ill keep an eye out for something that might work.
1 Like
Myrrdin
September 4, 2021, 6:19am
11
Somehow I missed this post. Thx for bumping
Love the science here but what is the practical goal ?
Separation of these isomeric mirrors achieves what ?
Uses would have to include non combustion related process and delivery methods I’m thinking a transdermal or sublingual application would be the only product route for this achievement
THCA is good for the skin but sure is spicy when orally consumed
2 Likes
squig
September 4, 2021, 6:22am
12
forming the esters and seeing what difference they have pharmacologically would be my thought.
or more down my line of thinking is the high for lets keep using
THCA-B any different than the dominant isomer.
but to smoke waist of time as it cracks I agree.
until recently I honestly thought there was no use for
THCA unless it was smoked so I have no idea what
the other isomer would do.
methylated.
2 Likes
Myrrdin
September 4, 2021, 6:27am
13
I’m curious to know if there are any benefits to their separation in terms of crystallization as well
1 Like
squig
September 4, 2021, 6:28am
14
I doubt there is enough in there to notice to be honest.
again the position difference and its locality to the phenol
makes it an easy one to tell the difference in GC as well.
so as there are not a lot of reports of this in COA’s
I doubt there is enough in there to make any difference at all.
I think this one is in the realms of synthesis only for us
to experience it.
Myrrdin
September 4, 2021, 6:32am
15
Would a more uniform structure not form a more dense and stable lattice structure resulting in a heavier clearer “diamond” ?
I believe @TheWillBilly spoke about having denser and therefore more potent stones at one point in the blue diamond thread
#spitballing
1 Like
squig
September 4, 2021, 6:35am
16
yep 100% true there.
but we are not even talking 0.1% or it would be in all COA’s.
I have not done a lot with THCA yet so give it some time.
but I am of the mind that being that I wish to go via CBD
too CBDA then do a cold isomerization I may just
come up with this compound as a side reaction.
though I have heard of others using this path with
great success and have heard of no one separating the two
isomers yet.
should show up easy on TLC as well so we will find out
over my next set of experiments.
density often comes from correctly seeding and then reducing
temp dure in crystallaztion in a very slow and controlled manor.
most I have read here are using hexane which will not allow this.
of course this may be due to some ability of hexane not
to cocrystalize with the acid but I am more in line with its
just a price thing and my thoughts stay the same.
you want a solvent that has as great a difference of solubilty
for THCA over a temperature range as possible.
and then you wish for a solvent that has a vapor pressure
around water or higher.
1 Like
squig
September 4, 2021, 6:44am
17
when I try it I will first be doing a dual solvent crystallization
(probably two or three of them)
this will require one solvent that THCA dissolves in and on that
does not.
they must both be missable with each other.
you heat the first solvent up and then add the THCA until
no more dissolves.
you then slowly add the other solvent to the mix that THCA is insoluble in.
when you start to see clouding or the beginning of precipitation
you then add a few drops of the soluble solvent to clear
solution again.
filter hot and leave to crystalize.
then once this is done repeat till very very pure.
then using only one solvent that falls inside the specifications
of the post above you recrystallize from seed and then
if all has worked out well you should get massive rocks.
ive had MDA crystals well over an inch using this and
so dense I have cracked a tooth trying to break them.
4 Likes
squig
September 4, 2021, 6:54am
18
we must at all times though take into account the temperature
that THCA cracks at so we can not go up to that temperature
when doing our crystalization.
this may also be the reason everyone is going hexane.
in heptane it may be possible at a boil to turn your THCA
too THC.
my thoughts to that is most here are buying sops and if I wrote
a sop I would make it as fool proof as possible.
not what I am doing I am trying to learn and teach so I am
more of the mind just use a pid to temp set and don’t crack your
acid off.
that way none of these hexane vapors will cause problems
with fire explosion or toxicity.
still much easy for me to say use hexane and you will not
crack the acid off.
but if we are going to try for as big and dense as possible
I honestly think this solvent is not the one to use.
mostly due to that problem of loosing hexane and not
being able to slowly crystalize and form a strong stable
lattice
anyone here ever tried a pressure crystallization ?
2 Likes
Myrrdin
September 4, 2021, 7:14am
19
Only @ 1bar with hydrocarbon gases n-butane and pentane
Tried with both of those solvents up to 125psi but lacking the vessel to go any higher……safely lol
1 Like
squig
September 4, 2021, 7:20am
20
ye thought it would have been tried here
no point with heptane as you will loose your carboxylic acid.
though I wonder if one was to use hexane and dry ice put it in
a sealed metal cylinder and then heat to get pressure and slowly
reduce temp what they would get.
I bet to some extent having an over pressure large enough of
carbon dioxide would to some extent prevent the equalibrium
moving to the right in regards to the decarboxylation reaction.
also no need to talk explosion proof mantles then either.
1 Like
Myrrdin
September 4, 2021, 7:24am
21
I believe @TwistedStill built a decarb vessel to preserve terpenes during decarb
So sometimes I have an idea, and actually have the time and resources to bring it to fruition.
I make my own personal carts, and some for medical folks. I want to be able to decarb with heat, while maintaining my terpenes…if possible.
I’ve made a pressure vessel, with a teflon liner to do the job. 3" triclamp, 2.650 ID, for a little added wall thickness. The teflon liner will eliminate transfer loss, and will make dealing with the decarbed oil a little easier. One PRV for good measure. Two 1/4…
2 Likes
the one with the acid on the bottom decarbs at a much higher temperature because theres hydrogen bonding coming off the hydroxyl which causes the regular acid to decarb at a much lower temperature, i believe @mitokid told me this
in theory a selective decarb could allow you to decarb mostly 1 which would allow seperation by column chromatography
kinda how cbd and thc can be partially decarbed and seperated
2 Likes
squig
September 4, 2021, 7:33am
23
yep two rather naked protons working on each other
1 Like
Myrrdin
September 4, 2021, 7:34am
24
Kinda sounds dirty don’t it ? Hehe
1 Like
I posted a link to a guy here who made a huge 150psi miner/reactor but cant find the link. Never seen anything like it before.
1 Like
This isn’t the one I was referring to but found this 150 psi miner
Diamond Miner (xtractordepot.com)
1 Like
mitokid
September 4, 2021, 5:48pm
28
If THCa-B really is found naturally, it gotta be due to rare mistakes by d9-THCa synthetase, accepting olivetolic acid with the ring flipped over.
I haven’t looked thoroughly, but I always thought that Mechoulam isolated THCa-B after reaction of THC with MMC.
How come the X-ray structure of THCa-B precedes that of THCa-A by several decades?
1 Like
That was my next question and conclusion, if natural it would have to be some strange hiccup or variation in the biosynthetic pathway.