SOP adaptable to almost all the other cannabinoids.
DM me.
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bumped
Bumpy Walnuts
bumpeter
With out getting into the SOP , we should have a bit of discussion concerning utility. I assume not only water soluble , but readily reverts to THC in stomach acid; or do you think the compound itself is active as a CB1 agonist.
Why the hemi designation…only one Na+ per two Succinate esters.
Does the entire thing decompose to THC et al. if you try to smoke it? Can you tell a bit more about the utility and or psychoactive aspects of the molecule as depicted.
Do you think your reagent would work on the Cannabinoics….
I was thinking some conversation about this interesting adduct might be better than bumps. Sort of fits into the category of acetylTHC, but the extra carboxylate/Na+ brings in some interesting aspects of polar protic chemistry and pH manipulation.
Regards,
The hemisuccinate moiety will be cleaved off by metabolism, not via bile acid. It’s a prodrug, the utility is in more consistent and higher bioavailability
Of what I understand of pharmacokinetics, it would be unlikely to cross the BBB without metabolization
because Succinic acid is a dicarboxylic acid, of which only one is esterified
nope, but likely broken down by gut mucosa enzymes or in blood
It’s water soluble THC, can either be dissolved in oral formulations, as an injectable or suppository.
Ok, @lolwut what enzyme in the first pass hepatic step?
“The utility is more consistent and higher bioavailability”…did you just make that up? From the point of edibles, you get the highest bioavailability by absorption of THC with the lipid lymphatic pathway. @roiplk: I simply asking how is it you get fucked up eating this drug. Have you eaten 50 or 100 mgs? Just tell us. Eat 50 mgs with water, eat 50 mgs of THC on another day and then another day eat 50 mgs with a piece of toast and 3 pads of butter. Give us the bioassay results.
The use of “hemi” in your nomenclature here is a bit confusing. wouldn’t it be something more like “THC hydrogen succinate mono sodium”? Not considering any hydrates that might occur ? I would guess you use an anhydrous aprotic polar solvent for the SOP chem. Purposefully avoiding detail. But then the Na salt prep, we know what, capisce, and it would seem some aqueous in the endpoint. so you are sure there is no water. My work with cannabinoic acids…I find it is sometimes difficult to get rid of the last bit of water and the products are very hydroscopic.
I think your product has great potential, thus the discussion.
It might sell better if you do some personal bioassays about pharmacokinetics of absorption and metabolism in the hepatic portal system, ??? and be assured that the adduct itself is not a CB1 agonist? What is really interesting is no one really knows how THC molecule is transported in the blood stream. If absorbtion is via the lipid lymphatic system, we would assume as some micelle. Similar when dealing with lung epithelial and transport , ??? any ideas would be stimulating thought. There is no harm in giving it a one vape pipe try as well…who knows at that temp?
Best regards.
carboxylesterases or acetylesterases
The effects of esterification of thc on bioavilibility is studied, and the same trick has been used for other medications to solve bioavailbility issues
Furthermore, edibles effects are mediated by 11-Hydroxy-Δ9-tetrahydrocannabinol which i’d assume would be dramatically decreased when administered via prodrug.
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you guys are some smart motherfuckers
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i think you’re wrong there. The salt is a lot more polar and also heavier, thus pyrolysis might be very much prevalent over vaporization.
what could work instead is cold aerosolizing a solution of the hemisuccinate via pump and diffusor, i. e. the inhaler devices used for asthma.
Might even be less harsh than vaped THC, but depositing an active dose on lung epithelium might be an ambitious goal.
It’s also worth thinking about direct dry inhalation, but the same issues apply here. 20-50mg of powder to be inhaled is quite a lot and tissue irritation in the airways is the last thing anybody needs lol
Yes I agree, that is why I suggested you do it!
There is just no data on that compound. Clearly some DTA would be helpful. but The Simple’s way for the originator would be to hit it up on the vape pipe, you either get THC from breaking the ester or not… We know the cannabinoics decarb. So covalent things happen, obviously.
By the way…you do have clear evidence that when ingested the liver converts that in such a manner that you get high. I mean that is fundamental to the concept of calling it “water soluble THC”. Correct. And I don’t mean adding it to a brownie receipe and cooking, I mean make a saturated solution and drinking some.
There are many reasons I would not want to smoke it…but it your selling it to the recreation market, someone will. You should be able to advise up front on whether smoking/vaping is advisable? should this drug be labeled: “for human consumption only”…personally I would lawyer up on that one? I know you are rather savy about all such things. But you are only selling the SOP…correct?
Let us assume the best utility for this compound may be to dissolve in carbonated beverages/teas/ juices.
Seriously, have you taken it or do you know someone who has?
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This compound is well known, which you could have discovered by way of a simple Google search. As are succinate esters of other APIs. Very well known actually…
I have no idea why you would insist on those borderline idiotic suggestions you keep making.
There’s no reason to apply heat to this compound, let alone vape it. Just because some idiot ‘might’ do it doesn’t mean i have to.
I used to expect more scientifically minded questions from you, but what you’ve uttered here until now is a pile of hot garbage. I don’t know what’s wrong with you but you need to get your act together.
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Yes, very idiotic indeed, as I stated in my original note, I only wrote to stimulate discussion on the SOP you have for sale. Since the SOP is in fact rather idiotic in simplicity I tried to not discuss it as I know you feel it is valuable. Such methods may be well known , And such adducts may be standard as you suggest. I am just not completely on board concerning the speculated pharmacokinetics you suggest will occur. It is this simple: have you personally eaten this fucking drug or you haven’t. You seem to be avoiding this particular question.
I hope this conversation results in sales of your SOP.
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Post it
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Doing business with this poster could land you in prison
Buyer beware af
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It is Roi’s pitch and my intent was to stimulate conversation so he could make some sales.
What is obvious to Roi and myself…”simple “ is just an inside joke. I do not intend to publish any SOP’s on the subject. Seriously, I am interested in the pharmacokinetics of this drug as it is designed to be metabolized to THC by the liver.
It’s not, there are no liver enzymes required to split off the ester. That’s all done by either intestinal wall enzymes or esterases in blood.
Thank you, total ignorance here . I think that may be correct for CES2 . ? CES1 in liver, and prodrug metabolism …I just need an update….
There seems to be considerable substrate preferences between these two esterases. CES2 in intestinal tissues seems.a good guess for an alcohol like THC.
I dunno, ultimately the conversation boils down to “just boof some and report back if it’s dank”
I question if this is an instance of “whether they could instead of should” like, do we need THC analogs that are capable of crossing the BBB for maximum bioavailability? Are there any therapeutic/medicinal applications of complete saturation of CB1 or are we currently just effectively creating the weed equivalent of meth. Potency levels are already far above the needs of consumers with the advent of affordable THC-P/HHC-O
On the other hand, purity is highly sought after, and a THC that is truly water soluble instead of relying on gimmicks like nano-emulsification sounds neat.
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