1000x 
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There is actually no pharmacological data to prove that terpense modulate the effects of the cb1 or cb2 receptors. Iām not saying that terpenes donāt have any medical benefits. Simply that there is really no entourage effect with cannabinoids.
Even in the study you link that only mentionā¦ " Possible Underlying Mechanisms" there is no definitive proof of an āentorage effectā
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Well thereās definitely something going on, thereās plenty of at least anecdotal evidence of that, donāt you agree? Even if it hasnāt been completely explained?
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There is no conclusive proof of an entourage, however I find it hard to take seriously anyone who flatly denies itās existence.
I mean, fuck, just the fact that switching strains can overcome tolerance suggests there is more than one actor at play.
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Itās not terpenesā¦
Someone else shared this podcast with Hamilton and they actually touch on the subject tword the end of the episode.
āThe entourage effect is the astrology of weedā or something of those linesā¦
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ah, youāre saying entourage exists and terps aint it?
My experience with steam distilled CO2 terp fractions suggests whatever it is, is in that fraction
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I think the VSCs and esters do more to regulate effects than terps. I never bought the terpenes being the aspect that regulates effect. Botanical terpenes donāt change shit for me but the clear terps I make sure as hell do and I think the main difference is the esters, volitile sulphur compounds and maybe flavinoids. Sure smells way more like cannabis that botanically derived terpenes ever do.
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Ding ding ding
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Iāll take those sulfur compounds any day 
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100000000% agree
Botanical terpenes in d9 wont do shit for me to get me high
Those waterclear diamonds and terpenes you gave me thoughā¦ Totally different story
Theres just something about plant extracted live resin that gets me.
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https://pubs.acs.org/doi/10.1021/acsomega.1c04196
Theyre what gives Gelato its distinct smell and taste supposedly
Our results uncovered numerous VSCs, as shown in Figure 1, some of which have not been identified in nature. The compounds VSC3 āVSC7 each contain the prenyl functional groupāthe dimethyl analogue of the allyl groupāthe latter of which is found ubiquitously in garlic VSCs with reported health benefits. [(32,33,39,40)](javascript:void(0)
After identifying these compounds, we formulated the flower aroma profile of the cultivar Bacio Gelato using botanically derived isolates in a laboratory setting that confirmed 3-methyl-2-butene-1-thiol (VSC3 ) to be the major component of this aroma. We then measured VSCs in three cannabis extract products, an increasingly popular form of consumption, to determine if these compounds are retained throughout the hydrocarbon extraction process. We lastly conducted an indoor greenhouse trial to determine when these compounds are produced by the cannabis plant by monitoring the concentrations of VSCs as a function of growth. Our results establish two-dimensional gas chromatography coupled with mass spectrometry, flame ionization detection, and sulfur chemiluminescence as a powerful tool for elucidating the chemistry of the complex odor of cannabis .
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not trying to nit pic, but itās terpenes.
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Wow I canāt believe I havenāt heard of this. Apparently itās one of the chemicals that form in lightstruck beer too. Very cool. Prenylthiol - Wikipedia
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That would be the POE oil they put in most refrigerant cans to keep the systems lubed when they are charged. Iāve discussed previously that they are quite difficult to remove from the refrigerant (by design) and because of that I absolutely would not use actual refrigerant gas. Iām not sure where you would get unlubricated r134a
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Yeah, I have not seen ācleanā r134a. I was almost curious enough to distill a little bit in the small cls to see if that left behind what I suspect is in there. Just for shits and giggles
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nitpick*
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Awesome paper, thank you for posting it, Iām going to give it a thorough read.
Iām somewhat excited to see resolution on FID, mostly as Iām still intimidated to getting the mass spec up and running.
I started my journey into cannabis testing because I wanted to understand why smoking a bowl of one strain might have a positive impact but not the next. Starting with cannabinoids, then terpenes and I think this might be next, GCxGC. This article is very exciting to me.
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Just a reminder to those who say ābotannical terpenes donāt do it so itās not terpenesāā¦
just because itās not all terpenes doesnāt mean its ānot any terpenesā
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Username checks out
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