And a good day to you sir! Ahem welcome back @squig
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The man himself
Hello
Nice to meet you Squig
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well some good news.
there are quite a few new journals on rutracker thanks to the hyperlab crew.
I am downloading 4 pharmacy journals at the moment.
https://rutracker.nl/forum/tracker.php?nm=journal
https://rutracker.nl/forum/tracker.php?f=2528
if you find anything in there you want indexed let me know and ill make it next on the
cue.
also if I do get things wrong please let me know.
I am not working in this industry and there will be times when I miss understand something.
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@roguelabs
my money is on the complex as FeCl3 does.
there both lewis acids so I am sure the same effect to different degrees would happen.
the more I think about it the colloidal idea is not possible as Al is so reactive.
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Speaking of Lewis acids I was curious as to what the changing of solvents would do to my delta 8 reactions. I found that P-toluensfonic acid/cbd refluxed in Hexane for a short period of time seemed to produce a notable amount of CBC to the tune of 17%.
I’ve wondered if it was the lower heat and shorter time frame that did this or purely the different solvent but I had no one to ask, but then Just like that SQUIG IS BACK!
Happy to have you back buddy!
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thanx
cbd is legal here now yippy.
still there is a market to be had here big time.
only one company is trying for TGA approval if you follow the info online (of course
there could be heaps that I just don’t know about)
still pure CBD is untested in court yet but I think give it time and that will be
available as well as really CBD needs to be in higher doses if oral.
I must say I am glad I am not trying for TGA approval they can be really tough when
it comes to these kinds of things.
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most tosic reactions are done in toluene as water and heat will turn tosic acid back
into toluene and sulfuric acid.
this is not a problem if the solvent is toluene as it then converts back to tosic acid
and an equalibrium is formed.
I do not think sulfuric acid would react with hexane so I think whats happening
is first you are isomerizing to delta 9 then the double bond moves over to delta 8
as this is happening some of the tosic has reverted back to sulfuric which I think is
breaking the molecule after it has formed delta 8.
we can see the double bond has moved to the delta 8 position and the ether has
formed so it has isomerized past delta 9 too delta 8.
tosic acid comes as a hydrate and I think just heating it might start the hydrolysis back
to toluene and sulfuric acid.
is it possible to make CBC from delta 8 with sulfuric acid ?
anyway there is no way I can be sure of this.
if we check this azeotrope table we see that hexane does not form azeotropes with water
(well none that they mention and I think that would be a well known one)
so the water is staying in the solution to react with the tosic acid.
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I’m working on this reaction and coming across the same issues. I can get a light yellow oil out of my still with a silica scrub but it quickly turns to a translucent purple.
I’ll dump some literature around the topic that potentially explains what’s happening, hopefully bouncing some ideas around will help:
TiBA Reduction Mechanism: winterfeldt1975.pdf (1.1 MB)
Cannabinoid Oxidation: acs.jnatprod.9b01284.pdf (1.1 MB)
Induced Photolytic Oxidation: galalosman2018.pdf (1.6 MB)
I found it interesting to note that if the CBD/THC is oxidized to cannabinoquinoids, the ketones that are formed would be reduced to alcohol groups in the presence of TiBA.
My organic chemistry is rusty, but I think the mechanism with the TiBA reaction starts with an electron transfer from the C=C double bond. This would produce a carbocation which is free to be attacked by the nucleophilic hydroxyl group, closing the ring. Someone please correct me if i’m wrong here though, like I said my organic chemistry is rusty.
I also noticed you mentioned refluxing TiBA during the reaction in a differnet post, but i’ve found literature suggesting it degrades to DIBAL in the presence of heat (>50-60C) through a beta-hydride elimination. Have you experienced this?
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Ooo ^^ out of the woodworks with notes to share.
Thanks and welcome.
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The reaction profile of the Beam test was basicallyreplicated, without any substantial improvement of yield, bymetal oxidants [FeCl3,K3[Fe(CN)6], MnO2,Cr6±basedreagents, CuCl, CuCl2,Ag2O, NH4Ce(NO3)5] under bothcatalytic and stoichiometric conditions, as well as by peroxide
your third reference.
so if we see the salts they are using a lot of the are lewis acids.
so I would say the left over ions are making the hydroquinone then
giving a positive for a beams test.
you don’t see this if you isomerize CBD with acids so the
metal is whats doing it I think.
lewis acids are electron acceptors as are oxidating agents.
edit:
sorry that should have been benzoquinone not hydroquinone.
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I recently ran hexane ptsa with zero reflux quenched at peak exothermic…washed, neutralized and distilled.
Clear with slight yellow/golden hues.
In house hplc showed 82% D8 17%D9 balance <1% cbd.
Planning on sending to kca as with an additional toluene rxn (zero reflux) once I distill it.
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@squig we don’t know each other, but I’ve read lots and lots of your studies. Grateful for you brother.
Glad to see you back.
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To reflux or not to reflux…will reflux help with better d9 to d8 conversion? The times I refluxed I didn’t see much change maybe a little more D8. I never had an abundance of cbc. I’m interested how this came about @JedClampet
this post was forwarded to carl
now defend your self.
I have had enough either this stops or I do.
I do not ask for help or for business here.
I only post what I find that I think may help and make things
better for us all.
I am not attacking you so I shall leave it to the powers to be.
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I can not edit any more today so I shall put it in a new post.
steve we must come to terms with each other.
I think your a cop.
you wish to hurt people from the vespiary and the hive
and I am not sure how to come to terms with this.
you go to sites that talk about chemistry that you think is
disgusting and I still have no idea why.
what is your point ?
I am comp sci dick head.
tor ssh tunnels the lot.
why do you bother.
I believe in this scene and the hive and I am with out doubt
happy to admit when I am wrong and learn.
I am also happy to try what is taboo and then I am honest
with the result and not just my view but other chemists view of
me after trial.
ie I AM A BEE
what the fuck are you mate ?
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for referring to public posts of yours? i don’t think so 
being an actual snitch probably doesn’t add to your credibility here, even if it’s about something where you already snitched on yourself
i think you’re exhibiting signs of possibly drug-induced paranoia.
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deleted
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