Squig's back!

And a good day to you sir! Ahem welcome back @squig

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The man himself

Hello

Nice to meet you Squig

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Happy to see you back and doing well @squig!

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well some good news.

there are quite a few new journals on rutracker thanks to the hyperlab crew.

I am downloading 4 pharmacy journals at the moment.

https://rutracker.nl/forum/tracker.php?nm=journal

https://rutracker.nl/forum/tracker.php?f=2528

if you find anything in there you want indexed let me know and ill make it next on the

cue.

also if I do get things wrong please let me know.

I am not working in this industry and there will be times when I miss understand something.

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@roguelabs

my money is on the complex as FeCl3 does.

there both lewis acids so I am sure the same effect to different degrees would happen.

the more I think about it the colloidal idea is not possible as Al is so reactive.

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Speaking of Lewis acids I was curious as to what the changing of solvents would do to my delta 8 reactions. I found that P-toluensfonic acid/cbd refluxed in Hexane for a short period of time seemed to produce a notable amount of CBC to the tune of 17%.
I’ve wondered if it was the lower heat and shorter time frame that did this or purely the different solvent but I had no one to ask, but then Just like that SQUIG IS BACK!
Happy to have you back buddy!

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Wb @squig :octopus::grinning::v:t2:

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thanx

cbd is legal here now yippy.

still there is a market to be had here big time.

only one company is trying for TGA approval if you follow the info online (of course

there could be heaps that I just don’t know about)

still pure CBD is untested in court yet but I think give it time and that will be

available as well as really CBD needs to be in higher doses if oral.

I must say I am glad I am not trying for TGA approval they can be really tough when

it comes to these kinds of things.

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most tosic reactions are done in toluene as water and heat will turn tosic acid back

into toluene and sulfuric acid.

this is not a problem if the solvent is toluene as it then converts back to tosic acid

and an equalibrium is formed.

I do not think sulfuric acid would react with hexane so I think whats happening

is first you are isomerizing to delta 9 then the double bond moves over to delta 8

as this is happening some of the tosic has reverted back to sulfuric which I think is

breaking the molecule after it has formed delta 8.

we can see the double bond has moved to the delta 8 position and the ether has

formed so it has isomerized past delta 9 too delta 8.

tosic acid comes as a hydrate and I think just heating it might start the hydrolysis back

to toluene and sulfuric acid.

is it possible to make CBC from delta 8 with sulfuric acid ?

anyway there is no way I can be sure of this.

if we check this azeotrope table we see that hexane does not form azeotropes with water

(well none that they mention and I think that would be a well known one)

so the water is staying in the solution to react with the tosic acid.

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I’m working on this reaction and coming across the same issues. I can get a light yellow oil out of my still with a silica scrub but it quickly turns to a translucent purple.

I’ll dump some literature around the topic that potentially explains what’s happening, hopefully bouncing some ideas around will help:

TiBA Reduction Mechanism: winterfeldt1975.pdf (1.1 MB)

Cannabinoid Oxidation: acs.jnatprod.9b01284.pdf (1.1 MB)

Induced Photolytic Oxidation: galalosman2018.pdf (1.6 MB)

I found it interesting to note that if the CBD/THC is oxidized to cannabinoquinoids, the ketones that are formed would be reduced to alcohol groups in the presence of TiBA.

My organic chemistry is rusty, but I think the mechanism with the TiBA reaction starts with an electron transfer from the C=C double bond. This would produce a carbocation which is free to be attacked by the nucleophilic hydroxyl group, closing the ring. Someone please correct me if i’m wrong here though, like I said my organic chemistry is rusty.

I also noticed you mentioned refluxing TiBA during the reaction in a differnet post, but i’ve found literature suggesting it degrades to DIBAL in the presence of heat (>50-60C) through a beta-hydride elimination. Have you experienced this?

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Ooo ^^ out of the woodworks with notes to share.

Thanks and welcome.

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Sorry, the last question was directed at @Roguelab

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The reaction profile of the Beam test was basicallyreplicated, without any substantial improvement of yield, bymetal oxidants [FeCl3,K3[Fe(CN)6], MnO2,Cr6±basedreagents, CuCl, CuCl2,Ag2O, NH4Ce(NO3)5] under bothcatalytic and stoichiometric conditions, as well as by peroxide

your third reference.

so if we see the salts they are using a lot of the are lewis acids.

so I would say the left over ions are making the hydroquinone then

giving a positive for a beams test.

you don’t see this if you isomerize CBD with acids so the

metal is whats doing it I think.

lewis acids are electron acceptors as are oxidating agents.

edit:

sorry that should have been benzoquinone not hydroquinone.

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I recently ran hexane ptsa with zero reflux quenched at peak exothermic…washed, neutralized and distilled.
Clear with slight yellow/golden hues.
In house hplc showed 82% D8 17%D9 balance <1% cbd.
Planning on sending to kca as with an additional toluene rxn (zero reflux) once I distill it.

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@squig we don’t know each other, but I’ve read lots and lots of your studies. Grateful for you brother.
Glad to see you back.

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To reflux or not to reflux…will reflux help with better d9 to d8 conversion? The times I refluxed I didn’t see much change maybe a little more D8. I never had an abundance of cbc. I’m interested how this came about @JedClampet

this post was forwarded to carl

now defend your self.

I have had enough either this stops or I do.

I do not ask for help or for business here.

I only post what I find that I think may help and make things

better for us all.

I am not attacking you so I shall leave it to the powers to be.

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I can not edit any more today so I shall put it in a new post.

steve we must come to terms with each other.

I think your a cop.

you wish to hurt people from the vespiary and the hive

and I am not sure how to come to terms with this.

you go to sites that talk about chemistry that you think is

disgusting and I still have no idea why.

what is your point ?

I am comp sci dick head.

tor ssh tunnels the lot.

why do you bother.

I believe in this scene and the hive and I am with out doubt

happy to admit when I am wrong and learn.

I am also happy to try what is taboo and then I am honest

with the result and not just my view but other chemists view of

me after trial.

ie I AM A BEE

what the fuck are you mate ?

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for referring to public posts of yours? i don’t think so :rofl:

forward-this

being an actual snitch probably doesn’t add to your credibility here, even if it’s about something where you already snitched on yourself

i think you’re exhibiting signs of possibly drug-induced paranoia.

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deleted

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