I have really enjoyed reading for quite some time. I finally decided to post. I hope this is the right place and I have indeed searched this topic, but find only pieces of what I would like to discuss.
I see many discussions about solvents, mixes, polar/nonpolar without any connection to the work and methods available for finding ideal solvents.
The historical chemistry starts with the Hildebrand solubility parameter. This was expanded with the Hansen solubility parameters.
The next step is a TEAS plot. Plotting polarity, dispersion, and hydrogen bonding on one graph. Each solvent has a unique set of these three parameters.
You can find individual solvents to find the region of the plot that denotes the solvent parameters for solubility of your material. You can the use mixes in proportions that would bring the average parameters into your region, while the individual solvents would not be. We owe this to the paint and adhesives industry mainly, but it is the way to find the perfect solvent(s).
I see some people working on the scale, quality, and efficiency that this would be worthwhile. It’s not a tremendously hard task and we are realistically limited to a tiny subset of available solvents.