Ratio for increase in Distillate vs full spectrum edibles and drinkables

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Hello! First time posting here, have found some very useful info but can’t find anything related to this. Hope I’m posting in the right place.

Here’s the thing: we have a canna drink and edible op in Mx, we are changing the thc source from full spectrum QWET, to distillate for edibles and drinkables as it’s easier to aquire and saves some time and money(no more extraction involved). So I was wondering if anyone has found a ratio for increasing the dosing(mg) and acquiring a similar effect comparing full spec with distillate. After some research, we have found around 20-30% increase works kinda well but not on everyone, still the effects last a little less, but some say even 50% more increase would be needed to acquire similar effects on some people, some even more. Any advice on which way to follow for completing this change?

V.

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Switch to rosin. Disty sucks. You are worrying more about your bottom line than your customers experience.

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Say this to the 99% of edible and beverage market not just him.

Glad for you being the outlier but standard practice is stand practice for a reason. The D9 in your rosin isn’t any better than the D9 in a liter.

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I would beg to differ. Why is rosin far more expensive?

It provides a better effect in my opinion, even in edibles. Not to mention it is inherently not the same as conversation liters in terms of both potential safety or different composition of the THC itself. Chiral molecules are over my pay grade but I hear it discussed here a lot.

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There is such a thing as natural d9

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Yes. Live Rosin being the best form.

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What is natural D9

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Decarbed version of d9 thca that was produced in planta by a non-engineered synthase would be my response.

I believe you can even distinguish THCa produced by a thcsynthase vs the off target product from a CBDsynthase if you know what you’re looking for (published, lined here somewhere).

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Because it’s labor intensive and low yielding? Also marketing.

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I’m really surprised to hear others don’t think rosin produces a definitively better effect and flavor.

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To me, distillate is normally full spec, but I guess not in thc world. I would guess efficacy could be related to the lack of entourage. I think if I was trying to solve this I’d try adding some full spec material rather than bump up the isolate dose and compare results. Idk if both* is an option though lol.

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are you making the extract water soluble?

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IME the best bho absolutely holds up to the best rosin, and you’ll never have to worry about your banger with BHO. The key factor in all fire hash is fire in, fire out.

IF for some reason you value extra fats and lipids then I suppose rosin is the superior form of hash :man_shrugging: Rosin is far less scalable, proper live resin will never see temperatures over 0 degrees F until they hit a purging oven or a hot plate. It’s a fact some strains wont wash so far fewer cultivars are available to even make rosin and the process itself is far less repeatable at scale when trying to trained unskilled labor.

With edibles I’m not a fan of the planty taste that tends to come iwth rosin, though some love it, so it’s a preference thing. I will say anecdotally the efficacy of rosin edibles is much higher for me, though I hate the taste.

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I love the planty taste, which is why I do value fats and lipids, especially in edibles as I suspect they may also contribute to some synergy.

Everything you said is true, but I’d say on the bad end BHO has been far worse than the worst rosin I’ve tried. I don’t have interest in anything that wasn’t fire in fire out. Certain terpenes that are maintained in live resin are also harsh to my palette I suspect.

Really I hear a lot of talk about scalability, which is less of my concern than customer experience first and foremost. They want reliability and consistency while being as close to the natural plant expression as possible AKA water heat and pressure. Guess that’s been lost these days.

These days live resin can be REALLY hit or miss buying retail at least in my experience.

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Are plant lipids capable of crossing the BBB? Also if butane is maintaining terps that solventless doesn’t then wouldn’t that be closer to the plant expression?

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I’m not sure, can they? Educate me. Is there any way that they could be contributing to synergy? I’ve often thought chlorophyll contributed to the effect in RSO, for example.

As for your second question I think that’s fairly nuanced. I also think live Rosin retains other terpenes that live resin does not. It’s not either or, it’s complex in my eyes. Some terpenes develop with time, heat, certain solvents pull others, you know. All stuff I’m sure you know. Point being is I don’t think we have begun to understand some of the stuff with terpenes, now esters, flavonoids. There’s constantly new discoveries and trends.

I take your point, though. I’ll gladly take a dab of some nice live resin don’t get me wrong.

Edit, as per chat GPT:

Yes, some plant-derived lipids, fats, and waxes can help facilitate the crossing of the blood-brain barrier (BBB)—especially when they’re part of a carrier system or naturally bioactive.

Here’s a breakdown:

  1. Lipids and the Blood-Brain Barrier

The BBB is lipophilic—meaning it favors fat-soluble molecules. So:

Lipophilic compounds are more likely to cross the BBB.

Many psychoactive plant compounds (like THC) are lipid-soluble, which is why they can cross the BBB.

Lipid-based delivery systems can further enhance penetration.

  1. Fats and Oils (Triglycerides, MCTs, Omega Fats)

Medium-chain triglycerides (MCTs) can be used as carriers for cannabinoids and other compounds. They’re metabolized rapidly and may aid BBB delivery.

Omega-3 fatty acids are known to integrate into neural membranes and can cross the BBB.

Lipid conjugation (chemically linking a molecule to a fat) is sometimes used to help drugs cross.

  1. Plant Waxes

Generally too large and inert to cross the BBB themselves.

However, components of waxes like long-chain alcohols or phytosterols might have some neuroactive properties—but usually not BBB-penetrating by themselves unless modified or nano-emulsified.

  1. Nanoemulsions and Liposomes

Lipid-based nanoemulsions or liposomes are widely used in drug delivery to cross the BBB.

If you’re using a nano emulsion with plant lipids or cannabinoids, the formulation can be designed to enhance BBB permeability.

If you have a specific compound or plant in mind, I can break it down further—like whether it’s a wax, terpene, or cannabinoid

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You make some good points. As someone who primarily inhales his cannabis vs eating I do forget this thread is mostly in the context of edibles. I can see how extra fats in the extract could be beneficial to absorptionb in that roa. Plus I forgot THC and terps are lipids themselves. Though I think if you compared a resin vs rosin edible, where both inputs were mixed with mct that it would be hard to tell the difference in a blind test.

On the other side considering there’s so many chemicals in cannabis extracts that have yet to be isolated and identified what’s the likely hood they are all psychoactive? I think often times when people (myself included) talk about the extra fat in rosin we’re reffering to or operating with the hypothesis that those fats would fall into the 3rd category in your chat gpt response. That they are inert and are not capable of contributing to the effects of inhaled cannabis.

And on the subject of terpene development. Wouldn’t most of the factors you mentioned such as time and heat a bit independent of the extraction method? After all resin vs rosin it’s still gonna get dropped into a 500 degree banger and get all sorts of polymerization action going on. You can still whip a resin extract and allow it to age and cure as many people do with rosin.

Much like the edibles I think if you made some resin and rosin from the same starting material and controlled for as many variables as possible, it would be difficult to tell the difference in “feel” between the two.

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I think we have sort of diverted this discussion, if I can touch back on @Subsonik original post, I am going to assume that a full spectrum QWET extract is going to generally have more terpenes (at least the heads) compared to a distillate that has gone through high temp, low vac distillation.

Assuming that thought holds true, and if we look at some other recent threads regarding terpenes in edibles providing synergistic effects with the high, then it sounds like to me the only way to mimic the effect of the full spectrum would be to determine what the terpene difference might be and add those back in along with the distillate to the final edible formulation.

It sounds like, anecdotally from the other threads, the addition of terps into edibles creates extra effect of the edible high, I would assume that’s the effect in question. Distillate itself SHOULD be more potent than a full spectrum qwet extract, so in terms of THC dosage, I would expect to use LESS distillate than full spectrum QWET extract for the same THC dose, but potentially missing those extra terpenes would be my best guess at the root cause for not feeling the same “effect”.

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