I’m certain the google will give me some answers, but figure I’d run it by the community first. Couple of quick questions. I’ve been using vacuum filtration pretty much exclusively; dcvc, celite, bentonite etc. with fairly decent results. I have noticed that pressure seems to be much more commonly used on scale processes. Just curious as to the benefits/drawbacks for pressure vs vacuum for filtration.
I saw a couple hints that pressure is better for slower moving things like bentonite, is that true?
How does pressure effect a column (obviously I know HPLC exists so it mustn’t be a huge issue) in terms of channeling? Is there anything else I need to be wary of?
I"m guessing inert gas is ideal for this scenario? Nitrogen being the most obvious choice?
Can I take this a step further and make a filter/dcvc inside a co2 setup with a solvent gradient?
Is there common equipment people are using for pressure assisted filtration as opposed to vacuum? Buchner/hochstrom equivalent?
Thanks in advance!