What he means (I assume because I use the same language often…) is that there are not any cannabinoids left behind in the biomass, or if there are it is in undetectable amounts.
But regardless they treat the material as though it is somehow hazardous and dangerous.
For me that meant that they didn’t want us using it in animal bedding (even though it makes great bedding…) and they are crazy about not feeding anything it because what if the cows get high and get the humans drinking the milk high and other such nonsense.
That’s my take on it. And even proving it to them hasn’t been enough. Spending a lot of energy right now trying to convince people that animals and humans are not harmed from cellulose byproducts from these processes. x.X
There is some evidence that this happens - I happen to think its specific to neutralization which makes things into D9, and then that interacts with the stomach lining to cleave off the salt.
That’s just my opinion though. Its also possible that our test monkeys (not actual monkeys but interested workers and scientists) were never actually high. I didn’t do any pharmacokinetic studies or blood tests or anything like that. Its all self reported noise.
Generally trace quantities under 0.1% w/w of primarily neutral cannabinoids.
Once it’s Cannabis you can’t use it for anything else ever in Canada. One of the only officially and publically approved and endorsed destruction methods per Health Canada for anything that may possibly contain any cannabinoids is “mix 50:50 with kitty litter.”
If it’s been in a cannabis facility, it’s cannabis. Even if it used to be hemp. Through the magic of regulatory transubstantiation, once purchased by a cannabis company, hemp becomes cannabis and must be treated similarly to a biohazard.
Doesn’t matter if you’ve proven ND cannabinoids. Still cannabis, have to treat as cannabis.
Because I’ve spent quite a bit of time dealing with the regulations and regulators while running a legal cannabis operation here for the past too many years?
If you’re asking for reasons, my bet is on We Hates The Demon Lettuce, Think Of The Children, The Courts Forced Us To Allow You To Have the Cannabis And We’re Still Salty About It, and other similar things that are 100% illogical and round up to “because we said so, so fuckin deal with it, peasant.”
LOL…I was taking “ has Fuck all Cannabinoids in it” to mean …all the fucking cannabinoids you didn’t get out…
You just mean, it doesn’t have fuck left over….
Thank you both. The other way just didn’t make sense.
Perhaps that is some Saskatchewan , farm boy talk…but it doesn’t mean shit East of the Anacostia river.
I don’t think it was published yet, but this research continued with phenolate salts of other poly phenols. Super grateful to have been involved at Hebrew University. Feel free to DM me if you want more info.
Oeeff the ammonium salts are a trip
Never got it there where I wanted
Even thou @Photon_noir got pristine salt with that reagent
As for water extraction the bases one can use are few but the acids to neutralize are many wich one is recomended hcl is the obvious but rather have a weaker on like ascorbic or citric
Yes, thank you I agree about the acids. Ascorbic may stabilize cbda a bit as well. According to specs on cbda reference material from Sigma/Cerilliant.
Did you get to look at ACN crystallization at all.?
And while we are at it, perhaps the gurus of Amberlyst a21 resins can explain the detailed molecular actions in this scenario. stir it for one hour and monitor uptake?
Now that’s an interesting adsorption process? Desorb with KOH in i-propanol by stirring to two hours…OK …we know it works becasue the guy is good, but what is going on with Amberlyst a21? Non specific binding to back bone polymer?
It works the same without the ammonia base added? Amusing.
I didn’t end up going back to pursue graduate school with everything going on. In my heart I want to go back but the world is too crazy right now. I was in the Domb lab the pi for a lot of this research. The school of pharmacy has multiple programs that all work in the same building the cannabis research center was on the floor below where I worked, most of the faculty shared projects so there was a lot of interactions for collaboration.
Well I can not think of a better place to be “schooled” in cannabis chemistry…
You were lucky to have such an experience. Do you know of or see any heuristic value to the phenolate salts. As far as cannabinoic acids go, I can’t quite see a preparation of phenolate that doesn’t include the cannabinoate carboxyl salt as well.
It would seem they are all dual salts, i.e., the phenolate salts. With careful titration it would seem you could prepare mono alert salts of COO- +X.
It is specific though - yeah? Specific to acids with a certain pKa, and then specific with the Dowex 50WX8 for cleaving from the solid state so that it can be reclaimed. While both resins can then be regenerated to be used again.
This I had to do many times when I was in academic research lab - using solid state resins meant I could control other reactions and could get better seperation especially when I was working with phenols and long chain carbons whilst creating very large (11, 12, 13, 15) member carbon ring structures.
There is still ammonia in there - but perhaps less?
Sometimes I wish that I was still using these resins, they made life much simpler. But no one ever wanted to let me do this kind of work in a cannabis lab. They wanted what other people were already doing… you know?
Although - they did once let me do a bunch of water specific work (which we have mentioned here). Even so, I still think it would be easier on a resin. Of course, you might need A LOT of the resin and they can be expensive… but they are reusable, most of the time.
Such is life. Thanks for increasing the joy of my weekend.
