1100s have been out of service from HP long enough that they no longer make the parts; in many cases, it is possible to get used spares, or third-party. 1100s will be in service for the foreseeable future, 5-10 years minimum. The main constraint is the software: some versions won’t run on anything newer than XP, which has serious limitations including filename length and obvious security problems. If you have your control computer hooked up to the Internet, you’re just begging for viruses. If you don’t have it hooked up, then all your information exchange is either from thumb drives (still a virus risk) or on paper.
OP’s original question: LC 2030 vs. HP 1100. Not really a discussion here: the LC 2030 is still in production (last I checked), HP 1100s are ~20 years old at this point. $30k new instrument vs. $12k used instrument. Then there’s service; a new unit (whether Shimadzu or Agilent, since HP was spun off as its own company in 2000) should have a warranty for the first year. After that- things get pricey when they fall apart. Servicing an older HP 1100 is going to be easier: third-party companies spilling all over each other to fix it, because they’re not cheap… but still more affordable than a brand-new Agilent or Shimadzu.
Shimadzu service has never been good, and it’s no better with the “green rush.” I’ve had Agilent hop on a plane, fly an hour, come in, swap out a main board, and get back on a plane- the day after the service call was put in. Shimadzu is hit-and-miss: sometimes same day, maybe they even have the part, maybe they’re not answering their phone that day because they’re out of town and overwhelmed.
You want analysis and quantitation, particularly for carboxylated forms, you’re going to need HPLC, not a toy GC like SRI. You’re going to need software from the past 10 years. You’re also going to need standards; the big 4 will set you back about $300, the big 10 will set you back around $1000. You’re going to need solvents, solvent storage, the fire rating for storing and handling them, and then disposal when you’re done.
And, as much as the instrument vendors would like you to think otherwise, you’re going to need an experienced analytical chemist, preferably with HPLC experience, that knows how to make a proper calibration curve, and how to run samples. You’ll also need a 4-place balance (3-place is cute and all but if you want any amount of precision, you’re going to need to read to 0.1 mg), and a lab that can support a 0.1 mg balance: vibrations are ubiquitous.
Anyway, if you want to go with used stuff, a working 1100 is just the start of it. The software is probably the more difficult part these days.