I had a quick question for you guys regarding a liquid-liquid extraction. I perform THC remediation using a Gilson CPC and our “T-Free” Fraction comes out in an aqueous layer and an organic layer.
Organic layer is heptane and Aqueous layer is methanol and water.
We have cannabinoids in both layers and we are currently rotovapping both phases to fully collect the cannabinoids.
However, we are only able to reuse the heptane as it is not cost effective to separate the methaol from the water. So we end up disposing of freshly rotovapped MeOH/water.
Ideally we would like to find a way to separate the cannabinoids from the aqueous phase into the organic phase so we don’t have to waste time rotovapping MeOH/Water.
Some form of Heptane wash after adding polar solvent to the aqueous phase?
Any thoughts are appreciated.