JWH 210 chronicles

Hash and Stuff Pre/Post-Processing
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The reason why these synths can kill someone while you can literally never die on weed it is because most synths (with a few exceptions) are fully (potent) agonists of the cb1 receptor but thc is a partial agonist of those receptors, it is very much as Kratom been a partial agonist of opioids receptor while heroin is a full agonist…

I have found some synths to act as a partial agonist: JWH-073 (now forbidden) and EG-018 (really hard to get)

are the ones that come to my mind.

As you are pointing I think that mix it with an adequate quantity of cbd (something that for some strange reason nobody has been doing) is very important as cbd could compete for the cb1 and cb2 space on the receptors don’t allowing to the synths to a full agonist action…

It has been tested that even thc prevents against synth overdose as thc competes within the same receptors…

Things as a mixture of cbg cbn and cbd come to my mind as an interesting way of minorate the risk with those very wild substances…

Bear in mind that even thc alone (Marinol) has been shown with the potential to produce seizures in large doses, CURIOUSLY enough, seizures. A thing so frequently attributed to synth cannabinoids and an illness for which curiously enough full spectrums are so wonderful.

Seizures, probably an illness closely related to the cannabinoid system…

What I mean with the Marinol thing is that cbd, terpenes, and the rest of cannabinoids are very important for the weed lack of side effects as well.

If you could make a hash with a synth that guarantees the life of people and give them a more enjoyable high than weed , you are a king, unfortunately, this hash is sold most of the time as real hash (aka faking hash) which is very dangerous and no one deserves that.

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Don’t offense Roguelab I know your an excellent guy and you are trying to put some light in so dark practices, it kind of recomforts me they contacted you, a brilliant brain and good-hearted one in a crazy sub-world, just try your best as people lives are in play here…

I like your synth/cbd settler :wink:

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As veteran of the spice wave in the military around early 2010 I say keep researching. JWH 210 and JWH-018 is the most well documented and safe version of the syth we have from what i was reading back in the day. its the crazyness and control of the new RCs that nobody knows about. JWH has some research behind them.

I will say though I don’t think this information should be widely shared to much, we have another fentanyl repeat on our hands but the market will do what it wants. Spice is still avalaible on the American west coast, but now its marketed towards homeless people, underage buyers, and drug test worried folks, and it seems to became a real problem for them with some of these RCs. Like i tried smoking the new stuff around 2017 and it was such a wild grab bag of hot spots and quality, I think it was CHIMRA or one of those other derivatives, but it defiantly was not the same effect as the JWH line. I think it felt more like herion/benzo effect of blanking out then being consciously high and aware like normal d9/d8 effects, and I had withdrawl effects pretty badly after so minor use, really not a smart reward to risk ratio for harm reduction practices and does more damage then good as substance as whole because most people buying spice usually dont know the diffference between cannabinoids, but hey who hasnt put some weird shit into there body before, at least we documenting it now.

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both are full agonist buddy, dangerous shit you want it or not.

yeah your right, of the oldest ones I only tried ur-144 and i liked more than weed. But I dont like thc any way, now i have one of the news and micro-dosing it with cbd gives me a very pleasant paranoia free state I really like, very relaxing.

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yeah mate, my understanding has always been the CBD coutneracts the psychotic nature of THC and THC RCs. Thats why you go crazy on high THC/THCV cannabis (I think THCV is responsible for “sativa” paranoid/mental health issues relationship).

Its interesting that ive seen a lot of people have seizures even after first time use of the RCs, i had a buddy spend all night trying RC ketamine and then took one hit of spice and seizured up. very interesting and dangous reactions for sure.

I will say it was after the first banning of sythetics that I really saw issues in the USMC, like people really start having mental health issues, schizophrenic behavior, bunch of other issues. Some of these were sythetic cathinones as well not all cannabinoid focused. “bath salts” were also an issue. Between 2010-2012 I saw a radical shift in military policy and drug use that really had me concerned about where things were going with the synthetics. I Imagine most barracks atleast 25 to 35% of the folks in them were using narcotics of some sort (excluding etoh as a factor), and it became a huge test case i think for why legalization needs to happen as a public safety measure now.

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Hi bro you on wicker or what’s app

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I think with the synthetisch noids rising in popularity at the moment i should revive this tread
Damn with marocco locked at the moment
No at least very little hasj Gets exported the price of hasj are increased by 40% at the moment in europe
Everybody is jumping in the make fake non thc hasj at the moment
Crazy
The demand for cbd pollen the demand for thc for thc-a and synthetisch noids are treu the roof

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When talking about Thc-A , As i understand thca could be ∆8thca and/or ∆9thca if converted.
And then there is thca from biomass , wich one is the more likely to get.hold of if one shuld buy thca these days.
It feels.like a dangerous bussines model, importing something that can spontaneus transform itself to something illegal.

Are there both ∆8 and ∆9 thca?

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Yes both exist
Both crystelize
Both co crystelize

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IMG_5437
IMG_5437743×641 91 KB

IMG_5438
IMG_5438750×547 55.3 KB

Markets are in for a ride
If thc-a gets illegelized in Denmark and folks start fooling around making stuff like this

100% NON hemp or cannabis hasj
Bubbles smels and looks real but it is NOT
I fooled 3 coffeeshops with these products
Wich basicly means it will fool 90% of consumers extraction of ground Damiana is a bitch and the bubbling effect reagents are a health issue but it will get to the streets sooner than later mark my words

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Finally, a very, very, very interesting discussion about synthetics!
Firstly, Rogulab, not JWH-210, was most similar to THC, but JWH-018.
Secondly, the 10% dose you described in your mix is ​​dramatically high and extremely dangerous, so it’s best not to suggest such practices because it could be extremely dangerous, even deadly, to people who might treat your profound knowledge as an oracle without further analysis.
JWH-018 is 4-5 times stronger than THC, has a shorter duration of action, and is the safest and most similar in effects to THC. Moreover, there are the most medical and scientific studies on JWH-018, including those discussing the positive effects of this synthetic cannabinoid. JWH-210 is several dozen times more potent than THC and is a very strong full agonist at both the CB1 and CB2 receptors, so 10% might be enough :skull_and_crossbones::skull_and_crossbones::skull_and_crossbones:
Now, someone in this thread wrote something about cathinone derivatives and side effects. So, Mephedrone 4-MMC, which has been taking the world by storm since 2009, is significantly safer than cocaine, and in my opinion and that of those who have tried it, much, much more fucking enjoyable than cocaine. It provides euphoria, energy, and the sexual marathons and openness that follow cannot be replaced by anything else. Besides, those who know the market know that in the Netherlands, Poland, and other European countries, 4-MMC, 4-CMC, and 3-CMC are driving everything else off the market. And the psychoses the colleague is writing about are simply caused by marathons, lack of sleep, and neurotransmitter depletion. You can simply fall in love with the experience, especially the chemsex.
Now, for the record, I’ll post an ad soon and provide a link to a store selling ingredients for the incredibly simple synthesis of JWH-018, in the name of scientific research and development.

The fact that no one thought to add CBD isolate to herbal blends using synthetic cannabinoids was because the market at the time was completely unfamiliar with CBD products, much less isolate. The market blossomed later when the US legalized marijuana, then CBD began to appear in Europe, and finally, clever minds figured out that they could easily make THC from CBD isolate and then adulterate all the products like marijuana, hash, etc.

Very interesting thread. Thank you!

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No it s not you are mixing things up jwh 018 is full antagonist
Jwh 210 is not it s acctually a weak synth
You can verify by comparing ki numbers

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As for 4-mmc it is safer than the others mentioned but addictive
3-mmc and the laters are hell
MDMA still beats all these as a recreational drug in safety
I was personally in the group that launched 4-mmc with dr Z and Mr Bowden so I know plenty about it
As for Europe things have become significantly harder to produce since China and Europe are actively in search of precursor

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Perhaps there is a misunderstanding and we are talking about different substances, data comparing THC and synthetic cannabinoids JWH-210, JWH-018 vs THC below:

Comparison of potency: JWH-210, JWH-018 vs THC

JWH-018 and JWH-210 are significantly more potent than THC. Here’s a clear comparison based on scientific data (mainly CB1 receptor binding affinity – lower Ki = higher potency).

Potency Comparison (CB1 Receptor Affinity)

Substance Ki CB1 (nM) Potency vs THC Agonist Type
THC (Δ9-THC) ~40–41 nM 1x (reference) Partial
JWH-018 ~9 nM ~4–5x stronger Full
JWH-210 0.46 nM ~80–100x stronger Full

  • JWH-018 is about 4–5 times more potent than THC. A 3 mg dose of JWH-018 produces effects comparable to ~15 mg of THC.

  • JWH-210 is one of the strongest in the JWH series — roughly 100 times more potent than THC.

Key Differences

  • THC is a partial agonist at CB1 receptors → milder, more “ceiling” effect.

  • JWH-018 & JWH-210 are full agonists → much stronger and more unpredictable effects, with higher risk of anxiety, panic attacks, seizures, tachycardia, and psychosis.

Chemical Identification

Substance CAS Number Full Chemical Name
JWH-018 209414-07-3 1-Pentyl-3-(1-naphthoyl)indole / naphthalen-1-yl-(1-pentyl-1H-indol-3-yl)methanone
JWH-210 824959-81-1 (4-Ethylnaphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanone

Summary:
JWH-210 >> JWH-018 >> THC in terms of potency. These synthetic cannabinoids produce much more intense effects but carry significantly higher health risks compared to natural THC.

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1. Neurotoxicity (Brain Cell Damage)

These substances differ drastically in how they impact and potentially damage nerve cells.

  • MDMA (Highest serotonin neurotoxicity):

    • Exhibits proven, direct neurotoxic effects on the axons of serotonin neurons.

    • Leads to long-term depletion of serotonin levels, lower density of serotonin transporters (SERT), and mitochondrial damage within brain cells.

  • 4-MMC / Mephedrone (Low or debatable standalone neurotoxicity):

    • Preclinical studies show that when administered alone, mephedrone does not cause significant neurotoxicity to dopamine or serotonin terminals. It acts as a rapid releaser and reuptake inhibitor but does not destroy nerve endings the way MDMA does.

    • Critical Warning: Mephedrone drastically amplifies neurotoxicity if mixed with MDMA or amphetamines.

  • Cocaine (Functional and vascular neurotoxicity):

    • Does not directly destroy neurons in the same structural manner as MDMA. Instead, it causes neurotoxicity via cerebral oxygen deprivation (severe blood vessel constriction leading to micro-strokes) and intense oxidative stress.

    • MDMA: Highest Risk of Acute Metabolic Fatality

      • Hyperthermia and dehydration: MDMA severely impairs the body’s ability to regulate temperature. Most MDMA-related fatalities stem from heatstroke (body temperature exceeding 41–42°C), leading to multi-organ failure, or brain swelling caused by drinking excessive amounts of water (hyponatremia).

      • The “comedown” effect: Due to severe serotonin depletion, post-use depressive states tend to last the longest (often up to several days).

      4-MMC (Mephedrone): Highest Risk of Compulsive Redosing

      • Usage pattern: Mephedrone has a very short half-life, meaning its effects hit quickly and fade rapidly. This triggers an intense, immediate urge to redose (craving), frequently leading to multi-day binges without sleep.

      • Health consequences: These extended binges rapidly trigger acute psychosis, hallucinations, profound physical exhaustion, life-threatening tachycardia, and severe muscle breakdown that damages the kidneys (rhabdomyolysis).

      Summary: Which Substance Is More Dangerous?

      1. For structural brain cell damage: MDMA is the most dangerous.

      2. For sudden fatal medical emergencies (heart attack/stroke): Cocaine is the most dangerous.

      3. Mephedrone (4-MMC): Generally lower neurotoxicity than MDMA. Most studies show no lasting dopaminergic or serotonergic damage at standard doses under normal conditions. It can, however, potentiate the toxicity of other drugs (e.g., MDMA, amphetamines, methamphetamine) and cause issues during binges or in hot environments (oxidative stress, lipid peroxidation). Some transient effects on DA/5-HT transporters reported.

    • https://www.sciencedirect.com/science/article/abs/pii/S0006899320300962

    • Mephedrone Does not Damage Dopamine Nerve Endings of the Striatum but Enhances the Neurotoxicity of Methamphetamine, Amphetamine and MDMA - PMC

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3-CMC and 4-CMC are analogues of mephedrone 4-MMC. Common wisdom holds that the chloro derivatives are more toxic, but the active part of the molecule is essentially the same.

Many antidepressants and stimulants are chloro derivatives:

1. Chlorine Derivatives of Propiophenone (Aminoketones / Cathinones)

This group features exactly one official medication, which is structurally related to substituted cathinones (such as mephedrone):

  • Bupropion (Wellbutrin, Zyban):

    • Structure: Chemically designated as 3-chloro-N-tert-butyl-propiophenone (historically known as amfebutamone).

    • Mechanism: A norepinephrine-dopamine reuptake inhibitor (NDRI). It is prescribed for major depressive disorder and as a smoking cessation aid.

2. Tricyclic Antidepressants (TCAs) Containing Chlorine

A classic class of antidepressants where adding a chlorine atom to the ring structure significantly altered the receptor binding profile, usually boosting the serotonergic component:

  • Clomipramine (Anafranil):

    • Structure: A chlorinated derivative of imipramine (3-chloroimipramine).

    • Significance: One of the most potent antidepressants and anti-compulsive agents available (the gold standard for OCD treatment).

  • Lofepramine:

    • Structure: An imipramine derivative featuring a 4-chlorophenyl group in its structure.

  • Amoxapine:

    • Structure: A dibenzoxazepine derivative containing a chlorine atom at position 2 of its ring system.

3. Modern Antidepressants (Atypical, SSRIs, SARIs) Containing Chlorine

Chlorine serves as a critical substituent in several widely prescribed newer-generation medications:

  • Sertraline (Zoloft):

    • Structure: Contains a dichlorophenyl structure, meaning it has two chlorine atoms in the molecule: (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methylnaphthalen-1-amine.

    • Class: Selective serotonin reuptake inhibitor (SSRI).

  • Trazodone (Desyrel, Oleptro):

    • Structure: A triazolopyridine derivative carrying a 3-chlorophenyl ring.

    • Class: Serotonin antagonist and reuptake inhibitor (SARI), widely used for its antidepressant and sedative-hypnotic effects.

  • Nefazodone:

    • Structure: Structurally related to trazodone, also possessing a 3-chlorophenyl moiety (discontinued in many regions due to hepatotoxicity risks).
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Dude, stop using chatgpt. 210 is not that strong.

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Rogulab, I absolutely don’t question what you’re writing; I greatly respect your broad and deep knowledge. But everyone has the right to make a mistake. If you synthesized it yourself, you know what you’re getting, but perhaps you have a different synthetic cannabinoid, such as JWH-018, which, when added at 5% to a plant-based base or fake hash, produces very good results. I commented on your post just to prevent anyone from accidentally harming themselves or others. The data regarding JWH-210’s affinity for the CB1 and CB2 receptors comes from scientific studies, the same goes for JWH-18. Anyway, this is a very interesting thread about synthetics, and I was very inspired by your mix with dissolved CBD. :wink: Best regards :+1:

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But, yes, as you said, for example.at hyperreall JWH-210 has very good, positive opinions and sometimes perhaps, scientyfic researche are different then customers opinions. But in my opinion 10% it is very very high dose if JWH-210 is pure. Pure JWH-018 gives fast, very clear, strong effect. JWH-210 works with a delay of about 10 minutes and at such a dose it is easy to overdose.

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I have been wondering if it is the synthetic noids that gives hasch bad smell, something that smells like burnt broth cubes.

Smells horrific and clearly not d9 only.

Please write more of your experiences with the different noids , how they differ in effect from d9 and how to be able to tell .